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公开(公告)号：US20130142799A1
公开(公告)日：2013-06-06
申请号：US13681356
申请日：2012-11-19
申请人： Amgen, Inc.
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/73 , C07K2317/76
摘要： Disclosed are specific binding agents, such as fully human antibodies, that bind to angiopoietin-2. Also disclosed are heavy chain fragments, light chain fragments, and CDRs of the antibodies, as well as methods of making and using the antibodies.
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公开(公告)号：US20230159656A1
公开(公告)日：2023-05-25
申请号：US18054426
申请日：2022-11-10
申请人： Amgen Inc.
发明人： Olivier Nolan-Stevaux , Cong Li , Christopher M. Murawsky , Benjamin M. Alba , Neeraj Jagdish Agrawal , Kevin Graham , Jennitte LeAnn Stevens
CPC分类号： C07K16/3069 , A61P35/00 , C07K16/2809 , C07K16/2818 , A61K2039/505
摘要： The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.
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公开(公告)号：US11530274B2
公开(公告)日：2022-12-20
申请号：US16634571
申请日：2019-07-02
申请人： AMGEN INC. , XENCOR, INC.
发明人： Olivier Nolan-Stevaux , Cong Li , Christopher M. Murawsky , Benjamin M. Alba , Neeraj Jagdish Agrawal , Kevin Graham , Jennitte LeAnn Stevens , Gregory Moore
摘要： The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.
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公开(公告)号：US20210179731A1
公开(公告)日：2021-06-17
申请号：US16634571
申请日：2019-07-02
申请人： AMGEN INC. , XENCOR, INC.
发明人： Olivier Nolan-Stevaux , Cong Li , Christopher M. Murawsky , Benjamin M. Alba , Neeraj Jagdish Agrawal , Kevin Graham , Jennitte LeAnn Stevens , Gregory Moore
摘要： The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.
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公开(公告)号：US11891435B2
公开(公告)日：2024-02-06
申请号：US17558032
申请日：2021-12-21
申请人： AMGEN INC.
发明人： Neeraj Jagdish Agrawal , Kevin Graham , Agnes Eva Hamburger , Christopher Mohr , Derek E. Piper , Kenneth William Walker , Zhulun Wang , Cen Xu
IPC分类号： C07K16/00 , A61K39/395 , A61K39/00 , A61K49/00 , A61K49/16 , C12P21/08 , G01N33/53 , C07K16/18 , C07K16/28 , A61P25/06 , A61K38/22 , A61K47/68 , A61K38/17 , A61K51/10 , C07K14/575 , C07K16/26 , C07K14/72 , C07K14/47 , G01N33/74 , G01N33/68
CPC分类号： C07K16/18 , A61K38/2278 , A61P25/06 , C07K16/2869 , A61K38/1796 , A61K38/22 , A61K47/6843 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/545 , A61K2300/00 , C07K14/47 , C07K14/575 , C07K14/57563 , C07K14/72 , C07K16/00 , C07K16/26 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/70 , C07K2317/72 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C12N2501/30 , G01N33/6854 , G01N33/6896 , G01N33/74 , G01N2333/575 , G01N2333/5757 , Y02A50/30
摘要： The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.
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公开(公告)号：US11248043B2
公开(公告)日：2022-02-15
申请号：US16919032
申请日：2020-07-01
申请人： AMGEN INC.
发明人： Neeraj Jagdish Agrawal , Kevin Graham , Agnes Eva Hamburger , Christopher Mohr , Derek E. Piper , Kenneth William Walker , Zhulun Wang , Cen Xu
IPC分类号： G01N33/53 , A61K39/395 , A61K39/00 , A61K49/00 , A61K49/16 , C07K16/00 , C12P21/08 , C07K16/18 , C07K16/28 , A61P25/06 , A61K38/22 , A61K47/68 , A61K38/17 , A61K51/10 , C07K14/575 , C07K16/26 , C07K14/72 , C07K14/47 , G01N33/74 , G01N33/68
摘要： The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.
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公开(公告)号：US10738110B2
公开(公告)日：2020-08-11
申请号：US16246326
申请日：2019-01-11
申请人： AMGEN INC.
发明人： Neeraj Jagdish Agrawal , Kevin Graham , Agnes Eva Hamburger , Christopher Mohr , Derek E. Piper , Kenneth William Walker , Zhulun Wang , Cen Xu
IPC分类号： C07K16/00 , A61K39/395 , A61K39/00 , C12P21/08 , A61K49/00 , A61K49/16 , G01N33/53 , C07K16/18 , C07K16/28 , A61P25/06 , A61K38/22 , A61K47/68 , A61K38/17 , A61K51/10 , C07K14/575 , C07K16/26 , C07K14/72 , C07K14/47 , G01N33/74 , G01N33/68
摘要： The present invention relates to neutralizing antibodies of the human pituitary adenylate cyclase activating polypeptide type I receptor (PAC1) and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing headache conditions, such as migraine and cluster headache, using the neutralizing antibodies are also described.
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