公开(公告)号：US20180305465A1

公开(公告)日：2018-10-25

申请号：US15779325

申请日：2016-11-23

Applicant: AMGEN INC. ,  XENCOR, INC.

Inventor： Jennitte Leann Stevens ,  Mercedesz Balazs ,  Olivier Nolan-Stevaux ,  Gregory Moore ,  John Desjarlais ,  Matthew J. Bernett ,  Seung Y. Chu ,  Rumana Rashid ,  Umesh Muchhal

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/40 ,  A61P35/00

CPC classification number: C07K16/468 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/40 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92

Abstract: The present invention is directed to heterodimeric antibodies that bind CD3 and CD38.

公开(公告)号：US20250154281A1

公开(公告)日：2025-05-15

申请号：US19026217

申请日：2025-01-16

Applicant: AMGEN INC. ,  XENCOR, INC.

Inventor： Olivier Nolan-Stevaux ,  Cong Li ,  Christopher M. Murawsky ,  Benjamin M. Alba ,  Neeraj Jagdish Agrawal ,  Kevin Campbell Graham ,  Jennitte LeAnn Stevens ,  Gregory Moore

IPC: C07K16/30 ,  A61K39/00 ,  A61K40/11 ,  A61K40/42 ,  A61P35/00 ,  C07K16/28

Abstract: The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.

公开(公告)号：US20240301087A1

公开(公告)日：2024-09-12

申请号：US18602865

申请日：2024-03-12

Applicant: AMGEN INC. ,  XENCOR, INC.

Inventor： Olivier Nolan-Stevaux ,  Cong Li ,  Christopher M. Murawsky ,  Benjamin M. Alba ,  Neeraj Jagdish Agrawal ,  Kevin Campbell Graham ,  Jennitte LeAnn Stevens ,  Gregory Moore

IPC: C07K16/30 ,  A61K39/00 ,  A61P35/00 ,  C07K16/28

CPC classification number: C07K16/3069 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/2818 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92

Abstract: The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.

公开(公告)号：US11530274B2

公开(公告)日：2022-12-20

申请号：US16634571

申请日：2019-07-02

Applicant: AMGEN INC. ,  XENCOR, INC.

Inventor： Olivier Nolan-Stevaux ,  Cong Li ,  Christopher M. Murawsky ,  Benjamin M. Alba ,  Neeraj Jagdish Agrawal ,  Kevin Graham ,  Jennitte LeAnn Stevens ,  Gregory Moore

IPC: C07K16/30 ,  A61P35/00 ,  C07K16/28 ,  A61K39/00

Abstract: The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.

公开(公告)号：US20210179731A1

公开(公告)日：2021-06-17

申请号：US16634571

申请日：2019-07-02

Applicant: AMGEN INC. ,  XENCOR, INC.

Inventor： Olivier Nolan-Stevaux ,  Cong Li ,  Christopher M. Murawsky ,  Benjamin M. Alba ,  Neeraj Jagdish Agrawal ,  Kevin Graham ,  Jennitte LeAnn Stevens ,  Gregory Moore

IPC: C07K16/30 ,  C07K16/28 ,  A61P35/00

Abstract: The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.

公开(公告)号：US20240026002A1

公开(公告)日：2024-01-25

申请号：US18452395

申请日：2023-08-18

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  Gregory Moore ,  John Desjarlais ,  Michael Hedvat ,  Christine Bonzon

IPC: C07K16/28 ,  A61P35/00 ,  A61P37/06

CPC classification number: C07K16/2818 ,  A61P35/00 ,  A61P37/06 ,  C07K16/2803 ,  C07K16/2827 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/52 ,  C07K2317/33 ,  C07K2317/31 ,  A61K2039/507

Abstract: The present invention is directed to bispecific, heterodimeric immunomodulatory antibodies.

公开(公告)号：US20230227581A1

公开(公告)日：2023-07-20

申请号：US17817334

申请日：2022-08-03

Applicant: Xencor, Inc.

Inventor： Rumana Rashid ,  Umesh S. Muchhal ,  Gregory Moore ,  Alex Nishtal ,  Seung Chu ,  Sung-Hyung Lee ,  Yoon Kyung Kim

IPC: C07K16/40 ,  C07K16/28 ,  C07K16/46 ,  C12N15/63

CPC classification number: C07K16/40 ,  C07K16/2809 ,  C07K16/468 ,  C12N15/63 ,  C07K2317/565 ,  C07K2317/622

Abstract: The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3).

公开(公告)号：US20220380462A1

公开(公告)日：2022-12-01

申请号：US17339774

申请日：2021-06-04

Applicant: Xencor, Inc.

Inventor： Gregory Moore ,  Matthew Bernett ,  Rumana Rashid ,  John Desjarlais

IPC: C07K16/28

Abstract: The present invention is directed to optimized anti-CD3 variable sequences for use in a variety of bispecific formats, including those that utilize scFv components. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide.

公开(公告)号：US20220227867A1

公开(公告)日：2022-07-21

申请号：US17561613

申请日：2021-12-23

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  John R. Desjarlais ,  Gregory Moore ,  Suzanne Schubbert

IPC: C07K16/28 ,  C07K14/54 ,  C07K14/715 ,  C12N15/63

Abstract: The present invention is directed to novel targeted heterodimeric Fc fusion proteins comprising an IL-15/IL-15Rα Fc-fusion protein and a ICOS antibody fragment-Fc fusion protein.

公开(公告)号：US20220144956A1

公开(公告)日：2022-05-12

申请号：US17520590

申请日：2021-11-05

Applicant: Xencor, Inc.

Inventor： John R. Desjarlais ,  Gregory Moore ,  Suzanne Schubbert ,  Alex Nisthal

IPC: C07K16/28 ,  C12N15/63

Abstract: Provided herein are novel antibodies that bind TGFßRII and methods of making and using such antibodies. The antibodies provided advantageously block TGFß activity in a broad population of cells (e.g., active and unactivated hematopoietic cells), and find use wherein such blockage of TGFß activity is desirable, for example, for the treatment of cancers. In some embodiments, the antibodies are novel αTGFßRII×αCD5 and αTGFßRII×αPD-1 bispecific antibodies.