公开(公告)号：US20210230601A1

公开(公告)日：2021-07-29

申请号：US17050918

申请日：2019-04-25

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Hao YAN ,  Fei ZHANG ,  Xiaodong QI

IPC: C12N15/117

Abstract: In some embodiments, complex molecular knots with high crossing numbers are achieved by folding, following a prescribed folding order, single-stranded DNA or RNA of customized sequences into target shapes. Such complex molecular knots with high crossing numbers are useful for biomedical applications including use as immunostimulatory agents and/or protein hosts and carriers.

公开(公告)号：US20200270599A1

公开(公告)日：2020-08-27

申请号：US16812225

申请日：2020-03-06

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Jinglin FU ,  Zhao ZHAO ,  Neal WOODBURY ,  Hao YAN

IPC: C12N11/04 ,  C12N15/11 ,  C12N11/06 ,  C12N11/10

Abstract: The present disclosure describes a nanoparticle comprising a three dimensional DNA nanocage and a payload biological macromolecule, and methods of assembly thereof.