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公开(公告)号：US20240150392A1
公开(公告)日：2024-05-09
申请号：US18228604
申请日：2023-07-31
Inventor： Dongran HAN , Hao YAN
Abstract: Novel compositions and methods for engineering wireframe architectures and scaffolds of increasing complexity by creating gridiron-like DNA structures (FIG. 1). A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects, can be assembled according the methods presented herein.
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公开(公告)号：US20220056450A1
公开(公告)日：2022-02-24
申请号：US17520113
申请日：2021-11-05
Inventor： Hao YAN , Yung CHANG , Xiaowei LIU , Fei ZHANG , Xiaodong QI
IPC: C12N15/117
Abstract: Certain embodiments provide RNA nanostructure (e.g., comprising one single-stranded RNA (ssRNA) molecule, wherein the RNA nanostructure comprises at least one paranemic cohesion crossover), as well as compositions and methods of use thereof. In certain embodiments, such RNA nanostructures are immuno-modulatory (e.g., immuno-stimulatory).
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公开(公告)号：US20250090567A1
公开(公告)日：2025-03-20
申请号：US18727665
申请日：2023-01-10
Inventor： Hao YAN , Yang XU , Xiaodong QI , Guangbao YAO , Chen GONG , Yung CHANG , Theresa YIP
IPC: A61K31/7088 , A61K31/443 , A61K31/513 , A61K31/7072 , A61K45/06 , A61P35/00
Abstract: Described herein are compositions comprising RNA origami (RNAOG) which include 5-fluorouracil (5FU) or analogues thereof are described which can be used to both directly treat a cancer by inhibiting a biochemical pathway overexpressed in a cancer cell and indirectly treat a cancer by inducing an anti-cancer immune response. Also described herein are methods of using said compositions for treating cancer, inducing an anti-cancer immune response, and/or killing a cancer cell.
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公开(公告)号：US20250000892A1
公开(公告)日：2025-01-02
申请号：US18700992
申请日：2022-10-14
Inventor： Hao YAN , Yang XU , Xiaodong QIAN , Lu YU , Liangxiao CHEN
IPC: A61K31/713 , A61K47/68 , A61P35/00 , C07K19/00
Abstract: Described herein are RNA sequence (including siRNA, shRNA, and/or mRNA) carrier platforms for rapid and targeted delivery of siRNAs, shRNAs, and/or mRNAs into cytoplasm of tumor cells, to induce a tumor killing effect. Also described herein is are methods of treating cancer using the RNA sequence carrier platforms described herein.
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公开(公告)号：US20240158776A1
公开(公告)日：2024-05-16
申请号：US18481955
申请日：2023-10-05
Inventor： Jinglin FU , Zhao ZHAO , Neal WOODBURY , Hao YAN
Abstract: The present disclosure describes a nanoparticle comprising a three dimensional DNA nanocage and a payload biological macromolecule, and methods of assembly thereof.
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Patent Agency Ranking
公开(公告)号：US20210061845A1
公开(公告)日：2021-03-04
申请号：US16938474
申请日：2020-07-24
Inventor： Dongran HAN , Hao YAN
Abstract: Novel compositions and methods for engineering wireframe architectures and scaffolds of increasing complexity by creating gridiron-like DNA structures (FIG. 1). A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects, can be assembled according the methods presented herein.
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公开(公告)号：US20250051830A1
公开(公告)日：2025-02-13
申请号：US18700676
申请日：2022-10-12
Inventor： Hao YAN , Swarup DEY , Fei ZHENG
IPC: C12Q1/6825 , C12Q1/6818
Abstract: A nanostructure comprising: a) a base plate sheet comprising a single-duplex layer comprised of DNA origami configured in a planar arrangement, b) a pore configured within the center of the base plate sheet, and c) a multi-duplex layer-thick wall comprising a single-duplex layer comprised of DNA origami that extends downward from the base plate sheet on the periphery of the pore, wherein the base plate sheet comprises a single-stranded DNA region on the bottom surface for lipid membrane anchor modification.
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公开(公告)号：US20190240248A1
公开(公告)日：2019-08-08
申请号：US16208103
申请日：2018-12-03
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY
Inventor： Hao YAN , Qiao JIANG , Suping LI , Baoquan DING , Guangjun NIE
IPC: A61K31/7088 , A61K9/00 , A61K47/26 , C12N7/00 , A61K9/51 , C12N15/115 , A61P35/00
CPC classification number: A61K31/7088 , A61K9/0019 , A61K9/51 , A61K47/26 , A61P35/00 , B82Y5/00 , B82Y40/00 , C12N7/00 , C12N15/115 , C12N2310/16 , C12N2795/00022 , C12N2795/00032 , C12N2795/00042
Abstract: In certain embodiments, the present invention provides a DNA nanostructure nanorobot comprising: a single stranded DNA scaffold strand of about 5,000 to 10,000 bases in length; a plurality of staple strands of DNA, wherein each staple strands are about 20 to 40 bases in length, wherein each staple strand has a unique sequence and is hybridized to a specific position on the DNA scaffold strand, wherein the plurality of staple strands hybridized to the DNA scaffold form a sheet having a top surface and a bottom surface; and one or more fastener strands of DNA, wherein the one or more fastener strands of DNA is capable of fastening the sheet into an origami structure.
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9.发明公开公开(公告)号：US20230250487A1
公开(公告)日：2023-08-10
申请号：US18296915
申请日：2023-04-06
Inventor： Rizal HARIADI , Hao YAN , Swarup DEY
IPC: C12Q1/6886 , C12Q1/682 , C12Q1/6881
CPC classification number: C12Q1/6886 , C12Q1/682 , C12Q1/6881 , C12Q1/6841 , C12Q2600/158 , C12Q2600/178
Abstract: Disclosed herein are methods and compositions comprising transmembrane nanosensors, and their use to identify, detect, label, and isolate cells. In some embodiments, the nanosensors may be used in conjunction with a hybridization chain reaction to amplify a signal, and to aid in the detection, identification, labeling or isolation of cells.
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公开(公告)号：US20220177887A1
公开(公告)日：2022-06-09
申请号：US17553603
申请日：2021-12-16
Inventor： Yung CHANG , Hao YAN , Xiaodong QI , Fei ZHANG
IPC: C12N15/117 , A61K39/00
Abstract: Described herein are immuno-stimulatory RNA nanostructures (which comprises a single-stranded RNA (ssRNA) molecule, wherein the ssRNA molecule forms at least one paranemic cohesion crossover), as well as compositions and methods of use thereof.
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