公开(公告)号：US20250090567A1

公开(公告)日：2025-03-20

申请号：US18727665

申请日：2023-01-10

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Hao YAN ,  Yang XU ,  Xiaodong QI ,  Guangbao YAO ,  Chen GONG ,  Yung CHANG ,  Theresa YIP

IPC: A61K31/7088 ,  A61K31/443 ,  A61K31/513 ,  A61K31/7072 ,  A61K45/06 ,  A61P35/00

Abstract: Described herein are compositions comprising RNA origami (RNAOG) which include 5-fluorouracil (5FU) or analogues thereof are described which can be used to both directly treat a cancer by inhibiting a biochemical pathway overexpressed in a cancer cell and indirectly treat a cancer by inducing an anti-cancer immune response. Also described herein are methods of using said compositions for treating cancer, inducing an anti-cancer immune response, and/or killing a cancer cell.

公开(公告)号：US20220056450A1

公开(公告)日：2022-02-24

申请号：US17520113

申请日：2021-11-05

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Hao YAN ,  Yung CHANG ,  Xiaowei LIU ,  Fei ZHANG ,  Xiaodong QI

IPC: C12N15/117

Abstract: Certain embodiments provide RNA nanostructure (e.g., comprising one single-stranded RNA (ssRNA) molecule, wherein the RNA nanostructure comprises at least one paranemic cohesion crossover), as well as compositions and methods of use thereof. In certain embodiments, such RNA nanostructures are immuno-modulatory (e.g., immuno-stimulatory).

公开(公告)号：US20220177887A1

公开(公告)日：2022-06-09

申请号：US17553603

申请日：2021-12-16

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Yung CHANG ,  Hao YAN ,  Xiaodong QI ,  Fei ZHANG

IPC: C12N15/117 ,  A61K39/00

Abstract: Described herein are immuno-stimulatory RNA nanostructures (which comprises a single-stranded RNA (ssRNA) molecule, wherein the ssRNA molecule forms at least one paranemic cohesion crossover), as well as compositions and methods of use thereof.

公开(公告)号：US20210230601A1

公开(公告)日：2021-07-29

申请号：US17050918

申请日：2019-04-25

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Hao YAN ,  Fei ZHANG ,  Xiaodong QI

IPC: C12N15/117

Abstract: In some embodiments, complex molecular knots with high crossing numbers are achieved by folding, following a prescribed folding order, single-stranded DNA or RNA of customized sequences into target shapes. Such complex molecular knots with high crossing numbers are useful for biomedical applications including use as immunostimulatory agents and/or protein hosts and carriers.