公开(公告)号：US20200291040A1

公开(公告)日：2020-09-17

申请号：US16656237

申请日：2019-10-17

Applicant: AbbVie Inc.

Inventor： Ayman ALLIAN ,  Jayanthy JAYANTH ,  Mohamed-Eslam F. MOHAMED ,  Mathew M. MULHERN ,  Fredrik Lars NORDSTROM ,  Ahmed A. OTHMAN ,  Michael J. ROZEMA ,  Lakshmi BHAGAVATULA ,  Patrick J. MARROUM ,  Peter T. MAYER ,  Ahmad Y. SHEIKH ,  Thomas B. BORCHARDT ,  Ben KLÜNDER

IPC: C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20190023714A1

公开(公告)日：2019-01-24

申请号：US15891012

申请日：2018-02-07

Applicant: AbbVie Inc.

Inventor： Ayman ALLIAN ,  Jayanthy JAYANTH ,  Mohamed-Eslam F. MOHAMED ,  Mathew M. MULHERN ,  Lars Fredrick NORDSTROEM ,  Ahmed A. OTHMAN ,  Michael J. ROZEMA ,  Lakshmi BHAGAVATULA ,  Patrick J. MARROUM ,  Peter T. MAYER ,  Ahmad Y. SHEIKH ,  Thomas B. BORCHARDT

IPC: C07D487/14 ,  A61K47/38 ,  A61K31/4985 ,  A61K9/00 ,  A61K47/12

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.