公开(公告)号：US20220073530A1

公开(公告)日：2022-03-10

申请号：US17527717

申请日：2021-11-16

申请人： AbbVie Inc.

发明人： Ayman ALLIAN ,  Jayanthy JAYANTH ,  Mohamed-Eslam F. MOHAMED ,  Mathew MULHERN ,  Fredrik Lars NORDSTROM ,  Ahmed A. OTHMAN ,  Michael J. ROZEMA ,  Lakshmi BHAGAVATULA ,  Patrick J. MARROUM ,  Peter T. MAYER ,  Ahmad Y. SHEIKH ,  Thomas B. BORCHARDT ,  Ben KLÜNDER

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20220251101A1

公开(公告)日：2022-08-11

申请号：US17717486

申请日：2022-04-11

申请人： AbbVie Inc.

发明人： Ayman ALLIAN ,  Jayanthy JAYANTH ,  Mohamed-Eslam F. MOHAMED ,  Mathew MULHERN ,  Fredrik Lars NORDSTROM ,  Ahmed A. OTHMAN ,  Michael J. ROZEMA ,  Lakshmi BHAGAVATULA ,  Patrick J. MARROUM ,  Peter T. MAYER ,  Ahmad Y. SHEIKH ,  Thomas B. BORCHARDT ,  Ben KLÜNDER

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and various spondyloarthritic conditions, including types of axial spondyloarthritis (axSpA)), kits, methods of synthesis, and products-by-process. In various aspects, provided are methods for treating active non-radiographic axSpA (nr-axSpA) and methods for treating active ankylosing spondylitis (AS).

公开(公告)号：US20200317682A1

公开(公告)日：2020-10-08

申请号：US16905667

申请日：2020-06-18

申请人： AbbVie Inc.

发明人： Ayman ALLIAN ,  Thomas B. BORCHARDT ,  Jayanthy JAYANTH ,  Patrick J. MARROUM ,  Peter T. MAYER ,  Mathew M. MULHERN ,  Fredrik Lars Nordstrom ,  Ahmad Y. SHEIKH

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20180162865A1

公开(公告)日：2018-06-14

申请号：US15891306

申请日：2018-02-07

申请人： AbbVie Inc.

发明人： Thomas B. BORCHARDT ,  Ahmad Y. SHEIKH

IPC分类号： C07D487/14 ,  A61K47/38 ,  A61K31/4985 ,  A61K9/00 ,  A61K47/12

CPC分类号： C07D487/14 ,  A61K9/0053 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethy)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20210363149A1

公开(公告)日：2021-11-25

申请号：US17184194

申请日：2021-02-24

申请人： AbbVie Inc.

发明人： Ayman ALLIAN ,  Jayanthy JAYANTH ,  Mohamed-Eslam F. MOHAMED ,  Mathew M. MULHERN ,  Fredrik Lars NORDSTROM ,  Ahmed A. OTHMAN ,  Michael J. ROZEMA ,  Lakshmi BHAGAVATULA ,  Patrick J. MARROUM ,  Peter T. MAYER ,  Ahmad Y. SHEIKH ,  Thomas B. BORCHARDT ,  Ben KLÜNDER

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20210309667A1

公开(公告)日：2021-10-07

申请号：US17230288

申请日：2021-04-14

申请人： AbbVie Inc.

发明人： Ayman ALLIAN ,  Jayanthy JAYANTH ,  Mohamed-Eslam F. MOHAMED ,  Mathew MULHERN ,  Fredrik Lars NORDSTROM ,  Ahmed A. OTHMAN ,  Michael J. ROZEMA ,  Lakshmi BHAGAVATULA ,  Patrick J. MARROUM ,  Peter T. MAYER ,  Ahmad Y. SHEIKH ,  Thomas B. BORCHARDT ,  Ben KLÜNDER

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20200291040A1

公开(公告)日：2020-09-17

申请号：US16656237

申请日：2019-10-17

申请人： AbbVie Inc.

发明人： Ayman ALLIAN ,  Jayanthy JAYANTH ,  Mohamed-Eslam F. MOHAMED ,  Mathew M. MULHERN ,  Fredrik Lars NORDSTROM ,  Ahmed A. OTHMAN ,  Michael J. ROZEMA ,  Lakshmi BHAGAVATULA ,  Patrick J. MARROUM ,  Peter T. MAYER ,  Ahmad Y. SHEIKH ,  Thomas B. BORCHARDT ,  Ben KLÜNDER

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20190023714A1

公开(公告)日：2019-01-24

申请号：US15891012

申请日：2018-02-07

申请人： AbbVie Inc.

发明人： Ayman ALLIAN ,  Jayanthy JAYANTH ,  Mohamed-Eslam F. MOHAMED ,  Mathew M. MULHERN ,  Lars Fredrick NORDSTROEM ,  Ahmed A. OTHMAN ,  Michael J. ROZEMA ,  Lakshmi BHAGAVATULA ,  Patrick J. MARROUM ,  Peter T. MAYER ,  Ahmad Y. SHEIKH ,  Thomas B. BORCHARDT

IPC分类号： C07D487/14 ,  A61K47/38 ,  A61K31/4985 ,  A61K9/00 ,  A61K47/12

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.