公开(公告)号：US20220153765A1

公开(公告)日：2022-05-19

申请号：US17378321

申请日：2021-07-16

Applicant: AbbVie Inc.

Inventor： Benoit Cardinal-David ,  Vincent S. Chan ,  Kassibla Dempah ,  Brian P. Enright ,  Rodger F. Henry ,  Raimundo Ho ,  Ye Huang ,  Alexander D. Huters ,  Russell C. Klix ,  Scott W. Krabbe ,  Philip R. Kym ,  Yanbin Lao ,  Xiaochun Lou ,  Sean E. Mackey ,  Mark A. Matulenko ,  Peter T. Mayer ,  Christopher P. Miller ,  James Stambuli ,  Valentino J. Stella ,  Eric A. Voight ,  Zhi Wang ,  Geoff G. Zhang

IPC: C07F9/09 ,  A61K31/661 ,  C07F9/06 ,  C07C281/02 ,  C07C309/24 ,  C07C47/277 ,  A61K31/6615 ,  A61K45/06

Abstract: The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.

公开(公告)号：US20210379290A1

公开(公告)日：2021-12-09

申请号：US17151077

申请日：2021-01-15

Applicant: AbbVie Inc.

Inventor： Sean E. Mackey ,  Ji Zhou ,  Martin J. Gibler ,  Dennis Y. Lee

IPC: A61M5/315 ,  A61M5/145

Abstract: A syringe includes a barrel, a plunger, and a sealing member creating a seal between the plunger and the barrel. The barrel includes a first portion with a first inner diameter and a second portion with a second inner diameter that is larger than the first inner diameter. The sealing member engages the first portion of the barrel to give rise to a first contact pressure when the barrel is filled with product. The first contact pressure is sufficient to maintain a gas-tight seal over the expected temperature ranges −25° C. to 40° C. A first force is applied to the plunger to overcome the first contact pressure and move the plunger out of the first portion and into the second portion to dispense product. The sealing member engages the second portion of the barrel to give rise to a second contact pressure that is lower than the first contact pressure. A second force lower than the first force is sufficient to overcome the second contact pressure and move the plunger in the second portion to continue dispensing product. The syringe may include a restraining element for accommodating expansion of the product during freezing.

公开(公告)号：US20190375770A1

公开(公告)日：2019-12-12

申请号：US16210996

申请日：2018-12-05

Applicant: AbbVie Inc.

Inventor： Benoit Cardinal-David ,  Vincent S. Chan ,  Kassibla E. Dempah ,  Brian P. Enright ,  Rodger F. Henry ,  Raimundo Ho ,  Ye Huang ,  Alexander D. Huters ,  Russell C. Klix ,  Scott W. Krabbe ,  Philip R. Kym ,  Yanbin Lao ,  Xiaochun Lou ,  Sean E. Mackey ,  Mark A. Matulenko ,  Peter T. Mayer ,  Christiopher P. Miller ,  James Stambuli ,  Valentino J. Stella ,  Eric A. Voight ,  Zhi Wang ,  Geoff G. Zhang

IPC: C07F9/09 ,  A61K31/661 ,  C07F9/06 ,  C07C281/02 ,  C07C309/24 ,  C07C47/277 ,  A61K31/6615 ,  A61K45/06

Abstract: The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.