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公开(公告)号：US20220153765A1
公开(公告)日：2022-05-19
申请号：US17378321
申请日：2021-07-16
申请人： AbbVie Inc.
发明人： Benoit Cardinal-David , Vincent S. Chan , Kassibla Dempah , Brian P. Enright , Rodger F. Henry , Raimundo Ho , Ye Huang , Alexander D. Huters , Russell C. Klix , Scott W. Krabbe , Philip R. Kym , Yanbin Lao , Xiaochun Lou , Sean E. Mackey , Mark A. Matulenko , Peter T. Mayer , Christopher P. Miller , James Stambuli , Valentino J. Stella , Eric A. Voight , Zhi Wang , Geoff G. Zhang
IPC分类号： C07F9/09 , A61K31/661 , C07F9/06 , C07C281/02 , C07C309/24 , C07C47/277 , A61K31/6615 , A61K45/06
摘要： The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.
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公开(公告)号：US20190375770A1
公开(公告)日：2019-12-12
申请号：US16210996
申请日：2018-12-05
申请人： AbbVie Inc.
发明人： Benoit Cardinal-David , Vincent S. Chan , Kassibla E. Dempah , Brian P. Enright , Rodger F. Henry , Raimundo Ho , Ye Huang , Alexander D. Huters , Russell C. Klix , Scott W. Krabbe , Philip R. Kym , Yanbin Lao , Xiaochun Lou , Sean E. Mackey , Mark A. Matulenko , Peter T. Mayer , Christiopher P. Miller , James Stambuli , Valentino J. Stella , Eric A. Voight , Zhi Wang , Geoff G. Zhang
IPC分类号： C07F9/09 , A61K31/661 , C07F9/06 , C07C281/02 , C07C309/24 , C07C47/277 , A61K31/6615 , A61K45/06
摘要： The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.
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公开(公告)号：US09732045B2
公开(公告)日：2017-08-15
申请号：US15221156
申请日：2016-07-27
申请人： AbbVie Inc.
发明人： Shashank Shekhar , Thaddeus S. Franczyk , David M. Barnes , Travis B. Dunn , Anthony R. Haight , Vincent S. Chan
IPC分类号： C07D239/54 , A61K31/505 , C07D239/10 , A61K31/513 , A61K45/06 , A61K38/21 , A61K31/7056 , B01J31/24
CPC分类号： C07D239/54 , A61K31/513 , A61K31/7056 , A61K38/21 , A61K45/06 , B01J31/2423 , B01J2231/4211 , B01J2231/4227 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2231/49 , B01J2531/824 , C07D239/10 , A61K2300/00
摘要： This disclosure is directed to: (a) processes for preparing compounds and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compounds and salts; (c) pharmaceutical compositions comprising the compounds or salts; and (d) methods of use of such compositions.
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公开(公告)号：US20140371446A1
公开(公告)日：2014-12-18
申请号：US14467625
申请日：2014-08-25
申请人： AbbVie Inc.
发明人： Shashank Shekhar , Thaddeus S. Franczyk , David M. Barnes , Travis B. Dunn , Anthony R. Haight , Vincent S. Chan
IPC分类号： C07F9/6571 , C07F9/6584 , C07C41/09 , C07C315/04 , C07C273/18 , C07C1/30 , C07D209/34 , C07F5/02 , C07C15/14 , C07D295/033 , C07C319/18 , C07F9/40 , C07F9/6568 , C07C201/10
CPC分类号： C07F9/657163 , B01J31/189 , B01J31/2423 , B01J31/2466 , B01J31/2485 , B01J31/249 , B01J2231/344 , B01J2231/4227 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2531/0205 , B01J2531/0266 , B01J2531/0288 , B01J2531/824 , B01J2540/10 , B01J2540/40 , C07C1/30 , C07C1/321 , C07C15/14 , C07C17/093 , C07C17/361 , C07C41/09 , C07C45/68 , C07C201/10 , C07C253/30 , C07C273/1854 , C07C273/1863 , C07C303/40 , C07C315/04 , C07C319/14 , C07C319/18 , C07C2523/42 , C07C2523/44 , C07C2523/46 , C07C2523/52 , C07C2523/72 , C07C2523/75 , C07C2523/755 , C07C2527/14 , C07C2531/22 , C07C2531/24 , C07D209/34 , C07D239/54 , C07D295/033 , C07F5/027 , C07F9/40 , C07F9/65031 , C07F9/65515 , C07F9/6552 , C07F9/65683 , C07F9/6571 , C07F9/6584 , Y02P20/52 , C07C275/28 , C07C311/08 , C07C311/21 , C07C311/29 , C07C255/10 , C07C321/30 , C07C205/45 , C07C15/06 , C07C49/784 , C07C25/18
摘要： The disclosure is directed to: (a) phosphacycle ligands; (b) methods of using such phosphacycle ligands in bond forming reactions; and (c) methods of preparing phosphacycle ligands.
摘要翻译： 本公开涉及：（a）磷酸基配体; （b）在成键反应中使用这种磷酸基配体的方法; 和（c）制备磷酸基配体的方法。
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公开(公告)号：US20160263566A1
公开(公告)日：2016-09-15
申请号：US15164002
申请日：2016-05-25
申请人： AbbVie Inc.
发明人： Shashank Shekhar , Thaddeus S. Franczyk , David M. Barnes , Travis B. Dunn , Anthony R. Haight , Vincent S. Chan
IPC分类号： B01J31/24 , C07F9/6571 , C07C17/263 , C07C41/30 , C07F9/48 , C07F9/6558 , C07F9/6503 , C07F9/572 , C07F9/50 , C07C303/40 , C07D209/42 , C07D213/76 , C07D239/54 , C07C41/01 , C07C273/18 , C07C253/30 , C07C201/10 , C07D209/34 , C07C1/26 , C07F5/04 , C07C17/361 , C07D295/033 , C07C319/14 , C07C45/61 , C07F9/40 , C07F9/6568
CPC分类号： B01J31/2423 , B01J31/189 , B01J31/2419 , B01J31/2438 , B01J31/2466 , B01J31/2485 , B01J31/249 , B01J2231/4211 , B01J2231/4227 , B01J2231/4277 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2231/44 , B01J2531/0205 , B01J2531/0266 , B01J2531/0288 , B01J2531/824 , B01J2540/10 , B01J2540/40 , C07C1/26 , C07C1/30 , C07C1/321 , C07C17/093 , C07C17/2635 , C07C17/361 , C07C41/01 , C07C41/30 , C07C45/61 , C07C45/68 , C07C45/71 , C07C201/10 , C07C253/14 , C07C253/30 , C07C273/1854 , C07C273/1863 , C07C303/36 , C07C303/40 , C07C319/14 , C07C2531/24 , C07C2531/26 , C07D209/12 , C07D209/34 , C07D209/42 , C07D213/76 , C07D239/54 , C07D265/30 , C07D295/033 , C07F1/02 , C07F5/025 , C07F5/04 , C07F9/4021 , C07F9/4841 , C07F9/505 , C07F9/5072 , C07F9/509 , C07F9/572 , C07F9/65031 , C07F9/65583 , C07F9/65683 , C07F9/657163 , Y02P20/52 , C07C275/28 , C07C311/08 , C07C311/21 , C07C311/29 , C07C255/10 , C07C321/30 , C07C205/45 , C07C15/06 , C07C49/784
摘要： The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.
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公开(公告)号：US09199992B2
公开(公告)日：2015-12-01
申请号：US14644970
申请日：2015-03-11
申请人： AbbVie Inc.
发明人： Vincent S. Chan , Alan C. Christesen , Timothy A. Grieme , Yi-Yin Ku , Mathew M. Mulhern , Yu-Ming M. Pu
IPC分类号： C07D471/04 , C07C67/10 , C07C67/00 , C07C69/78
CPC分类号： C07D471/04 , C07C67/00 , C07C67/10 , C07C69/78 , C07C69/76
摘要： Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.
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公开(公告)号：US20150191437A1
公开(公告)日：2015-07-09
申请号：US14536192
申请日：2014-11-07
申请人： AbbVie Inc.
发明人： Shashank Shekhar , Thaddeus S. Franczyk , David M. Barnes , Travis B. Dunn , Anthony R. Haight , Vincent S. Chan
IPC分类号： C07D239/54 , A61K45/06 , A61K31/513
CPC分类号： C07D239/54 , A61K31/513 , A61K31/7056 , A61K38/21 , A61K45/06 , B01J31/2423 , B01J2231/4211 , B01J2231/4227 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2231/49 , B01J2531/824 , C07D239/10 , A61K2300/00
摘要： This disclosure is directed to: (a) processes for preparing compounds and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compounds and salts; (c) pharmaceutical compositions comprising the compounds or salts; and (d) methods of use of such compositions.
摘要翻译： 本公开涉及：（a）制备其特别是可用于抑制丙型肝炎病毒（HCV）的化合物及其盐的方法; （b）可用于制备化合物和盐的中间体; （c）包含所述化合物或盐的药物组合物; 和（d）使用这种组合物的方法。
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公开(公告)号：US20140275540A1
公开(公告)日：2014-09-18
申请号：US14207179
申请日：2014-03-12
申请人： ABBVIE INC.
发明人： Vincent S. Chan , Alan C. Christesen , Timothy A. Grieme , Yi-Yin Ku , Mathew M. Mulhern , Yu-Ming M. Pu
IPC分类号： C07D471/04 , C07C67/10
CPC分类号： C07D471/04 , C07C67/00 , C07C67/10 , C07C69/78 , C07C69/76
摘要： Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.
摘要翻译： 本文提供了一种制备凋亡诱导剂及其化学中间体的方法。 本文还提供了与本文提供的方法相关的新型化学中间体。
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公开(公告)号：US10174061B2
公开(公告)日：2019-01-08
申请号：US15715245
申请日：2017-09-26
申请人： AbbVie Inc.
发明人： Benoit Cardinal-David , Vincent S. Chan , Brian P. Enright , Ye Huang , Alexander D. Huters , Russell C. Klix , Scott W. Krabbe , Philip R. Kym , Yanbin Lao , Xiaochun Lou , Sean E. Mackey , Mark A. Matulenko , Peter T. Mayer , Christopher P. Miller , James Stambuli , Eric A. Voight , Zhi Wang , Geoff G. Zhang , Valentino J. Stella
IPC分类号： C07F9/09 , A61K31/661 , C07F9/06 , A61K31/6615 , C07C281/02 , C07C309/24 , C07C47/277 , A61K45/06
摘要： The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.
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公开(公告)号：US20180079762A1
公开(公告)日：2018-03-22
申请号：US15715245
申请日：2017-09-26
申请人： AbbVie Inc.
发明人： Benoit Cardinal-David , Vincent S. Chan , Kassibla Dempah , Brian P. Enright , Rodger F. Henry , Raimundo Ho , Ye Huang , Alexander D. Huters , Russell C. Klix , Scott W. Krabbe , Philip R. Kym , Yanbin Lao , Xiaochun Lou , Sean E. Mackey , Mark A. Matulenko , Peter T. Mayer , Christopher P. Miller , James Stambuli , Eric A. Voight , Zhi Wang , Geoff G. Zhang , Valentino J. Stella
IPC分类号： C07F9/09 , A61K31/661 , C07F9/06 , A61K45/06 , C07C47/277 , C07C309/24 , C07C281/02 , A61K31/6615
CPC分类号： C07F9/094 , A61K31/661 , A61K31/6615 , A61K45/06 , C07B2200/13 , C07C47/277 , C07C281/02 , C07C309/24 , C07F9/06 , A61K2300/00
摘要： The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.
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