PYRAZOLO[1,5-a]PYRIMIDINES
    14.
    发明申请
    PYRAZOLO[1,5-a]PYRIMIDINES 审中-公开
    吡咯并[1,5-a]吡啶

    公开(公告)号:US20070275963A1

    公开(公告)日:2007-11-29

    申请号:US11751282

    申请日:2007-05-21

    IPC分类号: A61K31/5377 A61K31/519

    CPC分类号: C07D487/04

    摘要: In its many embodiments, the present invention provides certain pyrazolo[1,5-a]pyrimidine compounds which can have utility as inhibitors of cyclin dependent kinases as well as methods of preparing such compounds. The compounds can have potential utility for the treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs.

    摘要翻译: 在其许多实施方案中,本发明提供了可用作细胞周期蛋白依赖性激酶抑制剂的某些吡唑并[1,5-a]嘧啶化合物以及制备此类化合物的方法。 该化合物可用于治疗,预防,抑制或改善与CDK相关的一种或多种疾病的潜在用途。

    Adjustable rotating shaft guard
    16.
    发明申请
    Adjustable rotating shaft guard 审中-公开
    可调式转轴防护罩

    公开(公告)号:US20060144201A1

    公开(公告)日:2006-07-06

    申请号:US11030240

    申请日:2005-01-06

    申请人: Ronald Doll

    发明人: Ronald Doll

    IPC分类号: B26D1/00

    CPC分类号: F16P1/00 Y10T83/04

    摘要: A rotating shaft guard assembly includes a first guard portion, a second guard portion and an end cap. A rectilinear portion defines a generally flat leg receipt area to mount a leg selected from one of a multitude of legs. The end cap is mountable to a semi-cylindrical guard portion in a press-fit manner. The end cap includes a stepped pyramid end which provide a shaft exit of a predetermined diameter by cutting off the circular steps which are smaller than the desired shaft diameter exit.

    摘要翻译: 旋转轴保护组件包括第一防护部分,第二防护部分和端盖。 直线部分限定大致平坦的腿部接收区域以安装从多根腿中的一个腿中选择的腿部。 端盖可以按压配合的方式安装到半圆柱形保护部分。 端盖包括台阶金字塔端,通过切除小于所需轴径出口的圆形台阶来提供预定直径的轴出口。

    NOVEL IMIDAZOPYRAZINES AS CYCLIN DEPENDENT KINASE INHIBITORS
    18.
    发明申请
    NOVEL IMIDAZOPYRAZINES AS CYCLIN DEPENDENT KINASE INHIBITORS 审中-公开
    新型咪达唑仑作为循环依赖性激酶抑制剂

    公开(公告)号:US20070155751A1

    公开(公告)日:2007-07-05

    申请号:US11680929

    申请日:2007-03-01

    IPC分类号: A61K31/498 C07D487/02

    CPC分类号: C07D487/04

    摘要: In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

    摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的咪唑并[1,2-a]吡嗪化合物作为细胞周期蛋白依赖性激酶的抑制剂,制备此类化合物的方法,含有一种或多种此类化合物的药物组合物,制备药物制剂的方法 包括一种或多种这样的化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与CDK相关的一种或多种疾病的方法。