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公开(公告)号:US11945780B2
公开(公告)日:2024-04-02
申请号:US17156403
申请日:2021-01-22
发明人: Alon Gorodetsky , David Joshua Dibble , Mehran Umerani , Amir Mazaheripour , Young Suk Park , Anthony Burke
IPC分类号: C07D215/06 , C07C5/02 , C07D215/04 , C07D215/12 , C07D215/18 , C07D221/06 , C07D221/12 , C07D401/14 , C08G18/78 , C08G73/06 , C08L79/02 , C01B32/152 , C01B32/182
CPC分类号: C07D215/06 , C07C5/02 , C07D215/04 , C07D215/12 , C07D215/18 , C07D221/06 , C07D221/12 , C07D401/14 , C08G18/7862 , C08G73/0688 , C08L79/02 , C01B32/152 , C01B32/182
摘要: Quinolines, polyquinolines, polybenzoquinolines, molecular segments of fullerenes and graphene nanoribbons, and graphene nanoribbons and processes for producing such materials are provided. The processes utilize a form of an aza-Diels-Alder (Povarov) reaction to first form quinolines and/or polyquinolines. In some such embodiments polyquinolines thus produced are used to form graphene nanoribbon precursors, and molecular segments and graphene nanoribbons. In many such embodiments the graphene nanoribbone precursors are formed from polybenzoquinolines.
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公开(公告)号:US20240025857A1
公开(公告)日:2024-01-25
申请号:US18036596
申请日:2021-11-15
申请人: H. Lundbeck A/S
发明人: Morten Jørgensen , Klaus Gjervig Jensen , Jarkko Tapani Rautio , Christoffer Gerner, Bavnhøj Hansen , Jette Bisgaard Boll , Lena Gustavsson , Anja Nørgaard Kjeldsen
IPC分类号: C07D221/06
CPC分类号: C07D221/06
摘要: The present invention provides sulfamate derivative prodrugs of the dopamine agonist (4aR,10aR)-1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol, their use in the treatment of conditions for which treatment with a dopamine agonist is therapeutically beneficial and pharmaceutical compositions comprising compounds of the invention. Compounds according to the invention are of formula (Id), wherein R1 and R2 are each independently selected from H, and substituent (iii) below, wherein * indicates the attachment point to oxygen, wherein R3 is selected from H and COR4, and wherein R4 is selected from H and C1-C6 alkyl, with the proviso that R1 and R2 cannot both be H,15 or a pharmaceutically acceptable salt thereof.
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公开(公告)号:US20160030414A1
公开(公告)日:2016-02-04
申请号:US14820176
申请日:2015-08-06
IPC分类号: A61K31/473 , A61K45/06 , C07D217/02 , C07C217/60 , C07C233/18 , C07D221/06 , C07C291/04
CPC分类号: A61K31/473 , A61K45/06 , C07C217/60 , C07C233/18 , C07C291/04 , C07D217/02 , C07D221/06 , C07D455/06 , C07D471/04
摘要: The present invention relates to new benzoquinolone inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof.
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公开(公告)号:US20150183799A1
公开(公告)日:2015-07-02
申请号:US14565047
申请日:2014-12-09
发明人: Yusuke NAKAMURA , Matsuo YO , Shoji HISADA , Feryan AHMED , Raymond HUNTLEY , Zohreh SAJJADI-HASHEMI , David M. JENKINS , Robert B. KARGBO , Wenge CUI , Polivina Jolicia F. GAUUAN , Joel R. WALKER , Helene DECORNEZ , Mahender GURRAM
IPC分类号: C07D495/04 , C07D213/64 , C07D401/04 , C07D519/00
CPC分类号: C07D495/04 , C07D213/64 , C07D221/06 , C07D221/16 , C07D401/04 , C07D401/10 , C07D487/04 , C07D513/04 , C07D519/00
摘要: Tricyclic compounds are provided. These compounds are PBK inhibitors, and are useful for the treatment of PBK related diseases, including cancer.
摘要翻译: 提供三环化合物。 这些化合物是PBK抑制剂,可用于治疗包括癌症在内的PBK相关疾病。
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公开(公告)号:US08962648B2
公开(公告)日:2015-02-24
申请号:US13202544
申请日:2011-03-29
申请人: Yusuke Nakamura , Yo Matsuo , Shoji Hisada , Feryan Ahmed , Raymond Huntley , Zohreh Sajjadi-Hashemi , David M. Jenkins , Robert B. Kargbo , Wenge Cui , Polivina Jolicia F. Gauuan , Joel R. Walker , Helene Decornez , Mahender Gurram
发明人: Yusuke Nakamura , Yo Matsuo , Shoji Hisada , Feryan Ahmed , Raymond Huntley , Zohreh Sajjadi-Hashemi , David M. Jenkins , Robert B. Kargbo , Wenge Cui , Polivina Jolicia F. Gauuan , Joel R. Walker , Helene Decornez , Mahender Gurram
IPC分类号: A61K31/44 , A61K31/38 , C07D455/04 , C07D333/50 , C07D495/04 , C07D221/06 , C07D487/04 , C07D513/04 , C07D221/16 , C07D401/10
CPC分类号: C07D495/04 , C07D213/64 , C07D221/06 , C07D221/16 , C07D401/04 , C07D401/10 , C07D487/04 , C07D513/04 , C07D519/00
摘要: Tricyclic compounds are provided. These compounds are PBK inhibitors, and are useful for the treatment of PBK related diseases, including cancer.
摘要翻译: 提供三环化合物。 这些化合物是PBK抑制剂,可用于治疗包括癌症在内的PBK相关疾病。
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公开(公告)号:US20140228331A1
公开(公告)日:2014-08-14
申请号:US14256094
申请日:2014-04-18
申请人: VM Pharma LLC
发明人: Jay Jie-Qiang Wu , Ling Wang
IPC分类号: C07D261/20 , A61K31/496 , A61K45/06
CPC分类号: C07D498/06 , A61K31/496 , A61K31/497 , A61K45/06 , C07D215/20 , C07D221/06 , C07D223/32 , C07D241/44 , C07D261/20 , C07D265/36 , C07D279/16 , C07D295/13 , C07D307/77 , C07D403/14 , C07D407/12 , C07D413/10 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D493/06 , C07D495/04 , C07D498/04 , C07D513/04
摘要: The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Related Kinases (Trk), in particular the nerve growth factor (NGF) receptor, TrkA. The invention further concerns the use of such compounds in the treatment and/or prevention of pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or a disease, disorder or injury relating to dysmyelination or demyelination or the disease or disorder associated with abnormal activities of NGF receptor TrkA.
摘要翻译: 本发明涉及新型合成取代的杂环化合物和含有能够抑制或拮抗受体酪氨酸激酶家族(Tropomysosin Related Kinases,Trk),特别是神经生长因子(NGF)受体TrkA的家族的合成取代的杂环化合物和药物组合物。 本发明还涉及这些化合物在治疗和/或预防疼痛,癌症,再狭窄,动脉粥样硬化,牛皮癣,血栓形成或与异常髓鞘或脱髓鞘有关的疾病,病症或损伤或与异常活动有关的疾病或病症 的NGF受体TrkA。
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公开(公告)号:US20140058106A1
公开(公告)日:2014-02-27
申请号:US13953449
申请日:2013-07-29
发明人: Tobias Ritter , Takeru Furuya , Hanns M. Kaiser
IPC分类号: B01J31/22 , C07C29/62 , C07C45/63 , C07D307/82 , C07C37/62 , C07C41/22 , C07D209/08 , C07C17/093 , C07C231/12
CPC分类号: B01J31/2295 , A61K49/06 , C07C17/093 , C07C29/62 , C07C37/62 , C07C41/22 , C07C45/63 , C07C53/10 , C07C231/12 , C07D209/08 , C07D221/06 , C07D307/82 , C07F15/0066 , C07C33/46 , C07C39/27 , C07C43/225
摘要: Described herein are fluorinated organic compounds and methods of making fluorinated organic compounds, for example, using palladium complexes. Also described herein are compositions and kits containing compounds and palladium complexes described herein.
摘要翻译: 本文描述了氟化有机化合物和制备氟化有机化合物的方法,例如使用钯络合物。 本文还描述了包含本文所述的化合物和钯络合物的组合物和试剂盒。
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公开(公告)号:US08377639B2
公开(公告)日:2013-02-19
申请号:US12823902
申请日:2010-06-25
申请人: Sean Ryder
发明人: Sean Ryder
IPC分类号: C12Q1/68 , A01N41/06 , A01N43/653 , A61K31/18 , A61K31/4196
CPC分类号: G01N33/566 , A61K31/37 , A61K31/407 , A61K31/4196 , A61K31/433 , A61K31/435 , C07C69/017 , C07C311/21 , C07C335/22 , C07D215/06 , C07D221/06 , C07D221/18 , C07D231/12 , C07D235/16 , C07D237/26 , C07D271/113 , C07D311/08 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/12 , C07D417/12 , C07D417/14 , C07D487/04 , C07D513/04
摘要: The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with parasitic infections and inflammatory disorders.
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公开(公告)号:US20130020559A1
公开(公告)日:2013-01-24
申请号:US13522202
申请日:2010-12-28
申请人: Tetsu Kitamura , Toru Watanabe , Toshihiro Ise
发明人: Tetsu Kitamura , Toru Watanabe , Toshihiro Ise
CPC分类号: C07D209/86 , C07D221/06 , C07D235/18 , C07D403/12 , C07D487/22 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , H01L51/0054 , H01L51/0072 , H01L51/0085 , H01L51/0087 , H01L51/0094 , H01L51/5012 , H01L51/5268 , H05B33/10
摘要: Provided is an organic electroluminescence device including a pair of electrodes composed of an anode and a cathode, a light emitting layer between the electrodes and an organic layer which is adjacent to the light emitting layer between the light emitting layer and the cathode, on a substrate, and the light emitting layer contains at least one compound having a carbazole structure and the organic layer adjacent to the light emitting layer contains at least one hydrocarbon compound having a specific structure.
摘要翻译: 本发明提供一种有机电致发光元件,其包括由阳极和阴极构成的一对电极,电极之间的发光层和与发光层和阴极之间的发光层相邻的有机层,在基板上 并且发光层含有至少一种具有咔唑结构的化合物,并且与发光层相邻的有机层含有至少一种具有特定结构的烃化合物。
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公开(公告)号:US20120153816A1
公开(公告)日:2012-06-21
申请号:US13393272
申请日:2010-08-24
申请人: Hiroo Takizawa , Saki Takada , Eiji Fukuzaki
发明人: Hiroo Takizawa , Saki Takada , Eiji Fukuzaki
CPC分类号: H01L51/0087 , C07D213/16 , C07D213/26 , C07D213/57 , C07D213/61 , C07D213/79 , C07D215/04 , C07D217/06 , C07D221/06 , C07D233/60 , C07D263/62 , C07D401/04 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/04 , C07F15/0033 , C07F15/0086 , C09B57/00 , C09B57/10 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/1033 , C09K2211/1037 , C09K2211/1044 , C09K2211/1051 , C09K2211/1059 , C09K2211/1088 , C09K2211/1092 , C09K2211/185 , C09K2211/187 , C09K2211/188 , H01L51/0072 , H01L51/0085 , H01L51/009 , H01L51/5016 , H05B33/10 , Y10S428/917
摘要: To provide an organic electroluminescence device having high luminous efficiency (for example, external quantum efficiency) and high durability and causing little chromaticity shift after device deterioration.An organic electroluminescence device material comprising a substrate having thereon a pair of electrode and at least one organic layer between the electrodes, the organic layer containing a light emitting layer, wherein any one layer of the organic layer contains, for example, as shown below, a metal complex having a group represented by formula (I).
摘要翻译: 为了提供具有高发光效率(例如,外部量子效率)和高耐久性的有机电致发光器件,并且在器件劣化之后导致很小的色度偏移。 一种有机电致发光器件材料,包括其上具有一对电极和在所述电极之间的至少一个有机层的衬底,所述有机层包含发光层,其中所述有机层的任何一层包含例如如下所示, 具有由式(I)表示的基团的金属络合物。
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