专利检索 ap:"Anil Saksena" 第 1 页

1.

发明申请
Novel inhibitors of hepatitis C virus NS3 protease 失效
标题翻译：新型丙型肝炎病毒NS3蛋白酶抑制剂

公开(公告)号：US20050267043A1

公开(公告)日：2005-12-01

申请号：US11065572

申请日：2005-02-24

申请人： Stephane Bogen , Weidong Pan , Sumei Ruan , Kevin Chen , Ashok Arasappan , Srikanth Venkatraman , Latha Nair , Mousumi Sannigrahi , Frank Bennett , Anil Saksena , F. Njoroge , Viyyoor Girijavallabhan

发明人： Stephane Bogen , Weidong Pan , Sumei Ruan , Kevin Chen , Ashok Arasappan , Srikanth Venkatraman , Latha Nair , Mousumi Sannigrahi , Frank Bennett , Anil Saksena , F. Njoroge , Viyyoor Girijavallabhan

IPC分类号： A61K31/401 , A61K31/403 , A61K31/4035 , A61K31/407 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/497 , A61K38/00 , A61K38/04 , C07D207/10 , C07D209/02 , C07D209/52 , C07D209/70 , C07D295/16 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/02 , C07D413/12 , C07D417/02 , C07D417/12 , C07D491/04 , C07D495/10 , C07K5/02 , C07K5/04 , C07K5/08 , C07K5/083 , C07K5/087 , C07D43/02

CPC分类号： C07D209/52 , A61K38/00 , C07D209/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/0205 , C07K5/0808 , C07K5/0812 , C07K5/0827

摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。

2.

发明申请
Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection 失效
标题翻译：利巴韦林 - 干扰素α联合治疗用于根除慢性丙型肝炎感染患者可检测的HCV-RNA

公开(公告)号：US20050004053A1

公开(公告)日：2005-01-06

申请号：US10885374

申请日：2004-07-06

申请人： Ashit Ganguly , Jinping McCormick , Raymond Lovey , Frank Bennett , Anil Saksena , Viyyoor Girijavallabhan

发明人： Ashit Ganguly , Jinping McCormick , Raymond Lovey , Frank Bennett , Anil Saksena , Viyyoor Girijavallabhan

IPC分类号： A61P31/12 , C07H19/056 , A61K31/7056

CPC分类号： C07H19/056 , Y10S514/894

摘要： Ribavirin derivatives represented by the formula V, pharmaceutical compositions containing them as well as the use of the ribavirin derivatives represented by the formula V for the preparation of a medicament for the treatment of susceptible viral infections, for example, chronic hepatitis C infections administrating, the ribavirin derivatives being represented by formula V are disclosed.

摘要翻译： 由式V表示的利巴韦林衍生物，含有它们的药物组合物以及由式V表示的利巴韦林衍生物用于制备用于治疗易感病毒感染的药物的用途，例如，施用的慢性丙型肝炎感染，公开了由式V表示的利巴韦林衍生物。

3.

发明申请
17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 INHIBITORS FOR THE TREATMENT OF ANDROGEN DEPENDENT DISEASES 失效
标题翻译： 17抗坏血酸脱氢酶3型抑制剂治疗原发性依赖性疾病

公开(公告)号：US20080004248A1

公开(公告)日：2008-01-03

申请号：US11836530

申请日：2007-08-09

申请人： Timothy Guzi , Yi-Tsung Liu , Ronald Doll , Anil Saksena , Viyyoor Girijavallabhan , Jonathan Pachter

发明人： Timothy Guzi , Yi-Tsung Liu , Ronald Doll , Anil Saksena , Viyyoor Girijavallabhan , Jonathan Pachter

IPC分类号： A61K31/495 , A61K31/435 , A61K31/56 , A61P17/14 , A61P35/00 , A61P35/02 , C07D221/06 , C07D241/04 , C07D401/14

CPC分类号： C07D401/14 , A61K31/435 , A61K31/495 , A61K31/56 , A61K45/06 , C07D211/16 , C07D241/04 , C07D241/08 , C07D401/04 , C07D401/06 , A61K2300/00

摘要： In its many embodiments, the present invention provides a novel class of compounds as inhibitors of type 3 17β-hydroxysteroid dehydrogenase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with type 3 17β-hydroxysteroid dehydrogenase using such compounds or pharmaceutical compositions.

摘要翻译： 在其许多实施方案中，本发明提供了一类新型化合物作为3β17β-羟基类固醇脱氢酶的抑制剂，制备此类化合物的方法，含有一种或多种这类化合物的药物组合物，制备包含一种或多种这类化合物的药物制剂的方法以及使用这些化合物或药物组合物治疗，预防，抑制或改善与3型17β-羟类固醇脱氢酶相关的一种或多种疾病的方法。

4.

发明申请
Novel inhibitors of Hepatitis C virus NS3 protease 失效
标题翻译：新型丙型肝炎病毒NS3蛋白酶抑制剂

公开(公告)号：US20070142301A1

公开(公告)日：2007-06-21

申请号：US11645181

申请日：2006-12-21

申请人： Stephane Bogen , Weidong Pan , Sumei Ruan , Kevin Chen , Ashok Arasappan , Srikanth Venkatraman , Latha Nair , Mousumi Sannigrahi , Frank Bennett , Anil Saksena , F. Njoroge , Viyyoor Girijavallabhan

发明人： Stephane Bogen , Weidong Pan , Sumei Ruan , Kevin Chen , Ashok Arasappan , Srikanth Venkatraman , Latha Nair , Mousumi Sannigrahi , Frank Bennett , Anil Saksena , F. Njoroge , Viyyoor Girijavallabhan

IPC分类号： A61K38/05 , A61K38/04 , C07K5/10 , C07K5/08

CPC分类号： C07D209/52 , A61K38/00 , C07D209/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/0205 , C07K5/0808 , C07K5/0812 , C07K5/0827

摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。

5.

发明申请
Novel peptides as NS3-serine protease inhibitors of hepatitis C virus 有权
标题翻译：新型肽作为丙型肝炎病毒的NS3-丝氨酸蛋白酶抑制剂

公开(公告)号：US20070032433A1

公开(公告)日：2007-02-08

申请号：US10052386

申请日：2002-01-18

申请人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping Mc Cormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse Wong , Latha Nair

发明人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping Mc Cormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse Wong , Latha Nair

IPC分类号： A61K38/06 , A61K38/04 , C07K17/00 , C07K16/00 , C07K7/00 , C07K5/00 , A61K38/00

CPC分类号： C07K5/0804 , A61K38/00 , C07K5/0202 , C07K5/0812 , C07K5/0827 , C07K7/02

摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。

6.

发明申请
17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases 失效

公开(公告)号：US20060142338A1

公开(公告)日：2006-06-29

申请号：US11360711

申请日：2006-02-23

申请人： Timothy Guzi , Yi-Tsung Liu , Ronald Doll , Anil Saksena , Viyyoor Girijavallabhan , Jonathan Pachter

发明人： Timothy Guzi , Yi-Tsung Liu , Ronald Doll , Anil Saksena , Viyyoor Girijavallabhan , Jonathan Pachter

IPC分类号： C07D211/06 , A61K31/445

CPC分类号： C07D401/14 , A61K31/435 , A61K31/495 , A61K31/56 , A61K45/06 , C07D211/16 , C07D241/04 , C07D241/08 , C07D401/04 , C07D401/06 , A61K2300/00

摘要： In its many embodiments, the present invention provides a novel class of compounds as inhibitors of type 3 17β-hydroxysteroid dehydrogenase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with type 3 17β-hydroxysteroid dehydrogenase using such compounds or pharmaceutical compositions.

7.

发明授权
17 β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases 失效
标题翻译： 17β-羟基类固醇脱氢酶3型抑制剂用于治疗雄激素依赖性疾病

公开(公告)号：US07053091B2

公开(公告)日：2006-05-30

申请号：US10735983

申请日：2003-12-15

申请人： Timothy J. Guzi , Yi-Tsung Liu , Ronald J. Doll , Anil Saksena , Viyyoor M. Girijavallabhan , Jonathan A. Pachter

发明人： Timothy J. Guzi , Yi-Tsung Liu , Ronald J. Doll , Anil Saksena , Viyyoor M. Girijavallabhan , Jonathan A. Pachter

IPC分类号： A61K31/496 , C07D401/14

CPC分类号： C07D401/14 , A61K31/435 , A61K31/495 , A61K31/56 , A61K45/06 , C07D211/16 , C07D241/04 , C07D241/08 , C07D401/04 , C07D401/06 , A61K2300/00

摘要： In its many embodiments, the present invention provides a novel class of compounds as inhibitors of type 3 17β-hydroxysteroid dehydrogenase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with type 3 17β-hydroxysteroid dehydrogenase using such compounds or pharmaceutical compositions.

摘要翻译： 在其许多实施方案中，本发明提供了一类新型化合物作为3β17β-羟基类固醇脱氢酶的抑制剂，制备此类化合物的方法，含有一种或多种这类化合物的药物组合物，制备包含一种或多种这类化合物的药物制剂的方法以及使用这些化合物或药物组合物治疗，预防，抑制或改善与3型17β-羟类固醇脱氢酶相关的一种或多种疾病的方法。

8.

发明申请
17 Beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases 失效
标题翻译： 17β-羟基类固醇脱氢酶3型抑制剂用于治疗雄激素依赖性疾病

公开(公告)号：US20060014755A1

公开(公告)日：2006-01-19

申请号：US11045967

申请日：2005-01-28

申请人： Timothy Guzi , Kamil Paruch , Alan Mallams , Jocelyn Rivera , Ronald Doll , Viyyoor Girijavallabhan , Jonathan Pachter , Yi-Tsung Liu , Anil Saksena

发明人： Timothy Guzi , Kamil Paruch , Alan Mallams , Jocelyn Rivera , Ronald Doll , Viyyoor Girijavallabhan , Jonathan Pachter , Yi-Tsung Liu , Anil Saksena

IPC分类号： A61K31/496 , C07D43/02

CPC分类号： C07D211/34 , C07D211/48 , C07D295/185 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/02 , C07D409/12 , C07D409/14 , C07D417/12

摘要： There are disclosed compounds of the formula (I): prodrugs thereof, or pharmaceutically acceptable salts of the compounds or of said prodrugs which are useful as inhibitors of Type 3 17β-Hydroxysteroid Dehydrogenase. Also disclosed: are pharmaceutical compositions containing said compounds and their use for the treatment or prevention of androgen dependent diseases.

摘要翻译： 公开了可用作3型17β-羟基甾体脱氢酶抑制剂的式（I）化合物：其前药或化合物或所述前药的药学上可接受的盐。还公开了：含有所述化合物的药物组合物及其用于治疗或预防雄激素依赖性疾病的用途。