公开(公告)号：US11723904B2

公开(公告)日：2023-08-15

申请号：US17411270

申请日：2021-08-25

Applicant: Altria Client Services LLC

Inventor： Feng Gao ,  Diane L. Gee ,  Phillip M. Hulan ,  Shuzhong Zhuang ,  William J. Burke

IPC: A61K31/465 ,  A61K9/20 ,  A61K9/00 ,  B29C48/00 ,  A61K45/06 ,  B29C48/285

CPC classification number: A61K31/465 ,  A61K9/0056 ,  A61K9/2059 ,  A61K9/2095 ,  A61K45/06 ,  B29C48/0022 ,  B29C48/297 ,  B29C2793/009 ,  B29C2793/0009

Abstract: A nicotine lozenge includes a body that is partially or wholly receivable in an oral cavity. The body includes a soluble-fiber matrix and nicotine or a derivative thereof dispersed in the soluble-fiber matrix. A nicotine lozenge may include at least 40 weight percent of soluble fiber. Soluble fiber in a nicotine lozenge may include maltodextrin. The nicotine lozenge is adapted to release the nicotine or a derivative thereof from the body when the body is received within the oral cavity of an adult consumer and exposed to saliva. A method of making nicotine lozenges includes forming a molten mixture of at least 40 weight percent soluble fiber, nicotine, and less than 15 weight percent water while maintaining a mixture temperature of less than 150° C. and portioning the molten mixture into a plurality of nicotine lozenges. The ingredients can be mixed to form the molten mixture in an extruder.

公开(公告)号：US11369129B2

公开(公告)日：2022-06-28

申请号：US16881627

申请日：2020-05-22

Applicant: Altria Client Services LLC

Inventor： Feng Gao ,  Frank Scott Atchley ,  Gregory Griscik ,  Christopher Joseph Dinovi ,  Phillip M. Hulan ,  Diane L. Gee ,  Jason Flora ,  Shuzhong Zhuang

IPC: A24B13/00 ,  A24B15/10 ,  A61K31/465 ,  A24B15/16

Abstract: An oral product includes a body that is wholly receivable in an oral cavity. The body includes a mouth-stable polymer matrix, cellulosic fibers embedded in the mouth-stable polymer matrix, and nicotine or a derivative thereof dispersed in the mouth-stable polymer matrix. The oral product is adapted to release the nicotine or derivative thereof from the body when the body is received within the oral cavity and exposed to saliva.

公开(公告)号：US10105320B2

公开(公告)日：2018-10-23

申请号：US14505988

申请日：2014-10-03

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Feng Gao ,  Diane L. Gee ,  Shuzhong Zhuang ,  Phillip M. Hulan ,  William J. Burke ,  Gerd Kobal

IPC: A61K9/20 ,  A61K9/00 ,  A61K8/73 ,  A61Q11/00 ,  A23G3/38 ,  A23G3/42 ,  A23G3/34

Abstract: A soluble fiber lozenge provided herein includes a body that is partially or wholly receivable in an oral cavity. The body includes a soluble-fiber matrix and one or more additives dispersed in the soluble-fiber matrix. In some cases, a soluble fiber lozenge provided herein includes at least 40 weight percent of soluble fiber. In some cases, soluble fiber in soluble fiber lozenge provided herein can include maltodextrin. The soluble fiber lozenge is adapted to release one or more additives from the body when the body is received within the oral cavity of a consumer and exposed to saliva. A method of making soluble fiber lozenges provided herein includes forming a molten mixture of at least 40 weight percent soluble fiber, one or more additives, and less than 15 weight percent water while maintaining a mixture temperature of less than 200° C. and portioning the molten mixture into a plurality of soluble fiber lozenges. In some cases, the ingredients can be mixed to form the molten mixture in an extruder.

公开(公告)号：US20250160388A1

公开(公告)日：2025-05-22

申请号：US19033830

申请日：2025-01-22

Applicant: Altria Client Services LLC

Inventor： Shuzhong Zhuang ,  Diane L. Gee

IPC: A24B15/16 ,  A23G4/04 ,  A23G4/06 ,  A23G4/08 ,  A24B13/00 ,  A24B15/28 ,  C07D401/04

Abstract: This document provides methods and systems for stabilizing nicotine and incorporating nicotine into one or more oral products. This document also provides oral products. Nicotine can be stabilized by mixing nicotine with a silicon oxide-containing porous solid such that the nicotine absorbs into pores of the porous solid to form a porous solid-nicotine mixture. In some cases, a porous solid-nicotine mixture can be combined with one or more binders and molded into an oral product.

公开(公告)号：US11771127B2

公开(公告)日：2023-10-03

申请号：US14505814

申请日：2014-10-03

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Feng Gao ,  Diane L. Gee ,  Shuzhong Zhuang ,  Phillip M. Hulan ,  William J. Burke

IPC: A24B13/00 ,  A24B15/16

CPC classification number: A24B13/00 ,  A24B15/16

Abstract: A nicotine tablet that includes a solid solution of soluble fiber and one or more sugar alcohols, the solid solution having a glass transition temperature of less than 40° C., and nicotine or a derivative thereof dispersed in the solid solution such that the nicotine or derivative thereof is released from the tablet when the tablet is chewed or dissolved within an oral cavity.

公开(公告)号：US11076631B2

公开(公告)日：2021-08-03

申请号：US16507243

申请日：2019-07-10

Applicant: Altria Client Services LLC

Inventor： Feng Gao ,  Shuzhong Zhuang ,  Diane L. Gee

IPC: A24B15/16 ,  C07D401/04 ,  A24B15/30 ,  A24B15/28 ,  A23G4/06 ,  A24B13/00

Abstract: This document provides methods and systems for stabilizing nicotine and incorporating nicotine into one or more oral products. This document also provides oral products. Nicotine can be stabilized by mixing liquid nicotine with cellulosic fiber such that the liquid nicotine absorbs into pores of the cellulosic fiber to form a cellulosic fiber-nicotine mixture. In some cases, a cellulosic fiber-nicotine mixture can be combined with one or more binders and molded into an oral product.

公开(公告)号：US20190175582A1

公开(公告)日：2019-06-13

申请号：US16214490

申请日：2018-12-10

Applicant: Altria Client Services LLC

Inventor： Feng GAO ,  Frank Scott Atchley ,  Gregory James Griscik ,  Christopher Joseph Dinovi ,  Phillip M. Hulan ,  Diane L. Gee ,  Jason Flora ,  Shuzhong Zhuang

IPC: A61K31/465 ,  B29C48/00 ,  A24B15/16 ,  A24B15/30 ,  A24B15/14 ,  A61K9/00 ,  A61K9/20 ,  A61K36/81 ,  A61K45/06 ,  A61J3/10

CPC classification number: A61K31/465 ,  A24B15/14 ,  A24B15/16 ,  A24B15/30 ,  A24B15/308 ,  A61J3/10 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2031 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2095 ,  A61K36/81 ,  A61K45/06 ,  B29C48/0011 ,  B29C48/0022 ,  B29C48/022 ,  B29K2075/00 ,  B29K2401/00 ,  B29K2407/00 ,  B29L2031/753

Abstract: An oral product includes a body that is wholly receivable in an oral cavity. The body includes a mouth-stable polymer matrix, cellulosic fibers embedded in the mouth-stable polymer matrix, and a mouth-soluble binder dispersed in the mouth-stable polymer matrix.

公开(公告)号：US09999243B2

公开(公告)日：2018-06-19

申请号：US14506002

申请日：2014-10-03

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Feng Gao ,  Diane L. Gee ,  Phillip M. Hulan ,  Shuzhong Zhuang ,  William J. Burke

IPC: A24B13/00 ,  A24B15/16

CPC classification number: A24B13/00 ,  A24B15/16

Abstract: An exhausted-tobacco lozenge provided herein includes a body that is partially or wholly receivable in an oral cavity. The body includes a soluble-fiber matrix, exhausted-tobacco fiber, and one or more additives (e.g. nicotine or a derivative thereof) dispersed in the soluble-fiber matrix. In some cases, an exhausted-tobacco lozenge provided herein includes at least 40 weight percent of soluble fiber. In some cases, soluble fiber in exhausted-tobacco lozenge provided herein can include maltodextrin. The exhausted-tobacco lozenge is adapted to release the nicotine or a derivative thereof from the body when the body is received within the oral cavity of an adult tobacco consumer and exposed to saliva. A method of making exhausted-tobacco lozenges provided herein includes forming a molten mixture of at least 40 weight percent soluble fiber, exhausted-tobacco fiber, one or more additives (e.g., nicotine), and less than 15 weight percent water while maintaining a mixture temperature of less than 150° C. and portioning the molten mixture into a plurality of exhausted-tobacco lozenges. In some cases, the ingredients can be mixed to form the molten mixture in an extruder.

公开(公告)号：US09872516B2

公开(公告)日：2018-01-23

申请号：US14162194

申请日：2014-01-23

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Feng Gao ,  Frank Scott Atchley ,  Gregory James Griscik ,  Christopher Joseph DiNovi ,  Phillip M. Hulan ,  Diane L. Gee ,  Jason Flora ,  Shuzhong Zhuang

IPC: A24B15/10 ,  A24B13/00 ,  A24B15/16

CPC classification number: A24B15/10 ,  A24B13/00 ,  A24B15/16 ,  A61K31/465

Abstract: An oral product includes a body that is wholly receivable in an oral cavity. The body includes a mouth-stable polymer matrix, cellulosic fibers embedded in the mouth-stable polymer matrix, and nicotine or a derivative thereof dispersed in the mouth-stable polymer matrix. The oral product is adapted to release the nicotine or derivative thereof from the body when the body is received within the oral cavity and exposed to saliva.

公开(公告)号：US12274276B2

公开(公告)日：2025-04-15

申请号：US14505965

申请日：2014-10-03

Applicant: ALTRIA CLIENT SERVICES LLC

Inventor： Feng Gao ,  Diane L. Gee ,  Phillip M. Hulan ,  Shuzhong Zhuang ,  William J. Burke ,  Gerd Kobal

IPC: A61K31/5415 ,  A23G3/40 ,  A23G3/42 ,  A23G3/54 ,  A61K9/00 ,  A61K9/20 ,  A61K31/196 ,  A61K31/21 ,  A61K31/4402 ,  A61K31/4468 ,  A61K31/485 ,  A61K31/513 ,  A61K31/522 ,  A61K31/53 ,  A61K31/55 ,  A61K31/565 ,  A61K31/568 ,  A61K31/57 ,  A61K31/706 ,  A61K45/06

Abstract: A tablet that includes a solid solution of soluble fiber and one or more sugar alcohols, the solid solution having a glass transition temperature of less than 40° C., and one or more additives dispersed in the solid solution such that at least one additive is released from the tablet when the tablet is chewed or dissolved within an oral cavity.