公开(公告)号：US10294303B2

公开(公告)日：2019-05-21

申请号：US15387542

申请日：2016-12-21

Applicant: AMGEN INC.

Inventor： Junming Yie ,  Donghui Shi ,  David J. Lloyd ,  Jinghong Wang ,  Glenn N. Sivits, Jr. ,  Murielle M. Veniant-Ellison ,  Renee Komorowski ,  Neeraj Agrawal ,  Darren L. Bates ,  Brandon C. P. Clavette ,  Ian N. Foltz ,  Shu-yin Ho ,  Christopher Murawsky ,  Xiaoshan Min ,  Zhulun Wang

IPC: A61K39/39 ,  C07K16/28 ,  A61K38/26 ,  A61K39/395 ,  A61K9/00 ,  A61K38/17 ,  A61K39/00

Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.