公开(公告)号：US11285156B2

公开(公告)日：2022-03-29

申请号：US16438349

申请日：2019-06-11

Applicant: Amgen Inc.

Inventor： John Gordon Allen ,  Brian Alan Lanman ,  Jian Chen ,  Anthony B. Reed ,  Victor J. Cee ,  Longbin Liu ,  Patricia Lopez ,  Ryan Paul Wurz ,  Thomas T. Nguyen ,  Shon Booker ,  Jennifer Rebecca Allen ,  Margaret Chu-Moyer ,  Albert Amegadzie ,  Ning Chen ,  Clifford Goodman ,  Jonathan D. Low ,  Vu Van Ma ,  Ana Elena Minatti ,  Nobuko Nishimura ,  Alexander J. Pickrell ,  Hui-Ling Wang ,  Youngsook Shin ,  Aaron C. Siegmund ,  Kevin C. Yang ,  Nuria A. Tamayo ,  Mary Walton ,  Qiufen Xue

IPC: A61K31/497 ,  C07D241/04 ,  A61K31/519 ,  A61K31/551 ,  A61K39/395 ,  A61P35/00

Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：US20250059205A1

公开(公告)日：2025-02-20

申请号：US18696946

申请日：2022-04-28

Applicant: AMGEN INC.

Inventor： Brian Alan Lanman ,  Ryan Paul Wurz ,  Wei Zhao ,  Xiaofen Li ,  Michael M. Yamano ,  Yunxiao Li ,  Ning Chen ,  Birgitte Weinreich Husemoen ,  Sebastian Leth-Petersen ,  Jose M. Medina ,  Kexue Li ,  Liping Pettus ,  Rene Rahimoff ,  Primali Vasundera Navaratne ,  Huan Rui ,  Christopher P. Mohr

IPC: C07D519/00 ,  A61K31/4995 ,  A61K31/517 ,  C07D487/08

Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: (I) wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.

公开(公告)号：US20240417412A1

公开(公告)日：2024-12-19

申请号：US18695688

申请日：2022-08-10

Applicant: AMGEN INC.

Inventor： Brian Alan Lanman ,  Wei Zhao ,  Ryan Paul Wurz ,  Primali Vasundera NAVARATNE ,  Liping PETTUS ,  Michael M. YAMANO ,  Ning Chen ,  Rene RAHIMOFF ,  Francesco MANONI ,  John STELLWAGEN

IPC: C07D519/00 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/553

Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.

公开(公告)号：US11090304B2

公开(公告)日：2021-08-17

申请号：US16402538

申请日：2019-05-03

Applicant: Amgen Inc.

Inventor： John Gordon Allen ,  Jennifer Rebecca Allen ,  Ana Elena Minatti ,  Qiufen Xue ,  Ryan Paul Wurz ,  Christopher M. Tegley ,  Alexander J. Pickrell ,  Thomas T. Nguyen ,  Vu Van Ma ,  Patricia Lopez ,  Longbin Liu ,  David John Kopecky ,  Michael J. Frohn ,  Ning Chen ,  Jian Jeffrey Chen ,  Aaron C. Siegmund ,  Albert Amegadzie ,  Nuria A. Tamayo ,  Shon Booker ,  Clifford Goodman ,  Mary Walton ,  Nobuko Nishimura ,  Youngsook Shin ,  Jonathan D. Low ,  Victor J. Cee ,  Anthony B. Reed ,  Hui-Ling Wang ,  Brian Alan Lanman

IPC: A61K31/517 ,  A61P35/00 ,  A61K31/4985 ,  A61K39/395 ,  C07D403/04 ,  C07D471/04

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：US11053226B2

公开(公告)日：2021-07-06

申请号：US16687546

申请日：2019-11-18

Applicant: Amgen Inc.

Inventor： Youngsook Shin ,  Victor J. Cee ,  Christopher M. Tegley ,  Brian Alan Lanman ,  Ryan Paul Wurz ,  Kevin C. Yang ,  Vu Van Ma ,  Daniel Erlanson ,  Joon Won Jeong ,  Raymond V. Fucini ,  Jeffrey Iwig

IPC: C07D403/14 ,  C07D401/14 ,  C07D403/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  A61P35/00

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：US10988485B2

公开(公告)日：2021-04-27

申请号：US16407889

申请日：2019-05-09

Applicant: Amgen Inc.

Inventor： Ana Elena Minatti ,  Jonathan Dante Low ,  Ryan Paul Wurz ,  Brian Alan Lanman ,  Victor J. Cee ,  Michael D. Bartberger ,  Margaret Chu-Moyer

IPC: C07D513/04 ,  A61K45/06 ,  C07K16/28

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：US10519146B2

公开(公告)日：2019-12-31

申请号：US15984855

申请日：2018-05-21

Applicant: Amgen Inc.

Inventor： Brian Alan Lanman ,  Jian Chen ,  Anthony B. Reed ,  Victor J. Cee ,  Longbin Liu ,  David John Kopecky ,  Patricia Lopez ,  Ryan Paul Wurz ,  Thomas T. Nguyen ,  Shon Booker ,  Nobuko Nishimura ,  Youngsook Shin ,  Nuria A. Tamayo ,  John Gordon Allen ,  Jennifer Rebecca Allen

IPC: C07D471/04 ,  C07D487/04 ,  C07D403/04 ,  C07D401/04 ,  C07D475/00 ,  A61K31/496 ,  A61K31/519 ,  A61P35/00 ,  C07D417/04 ,  A61K38/07 ,  C07D487/08 ,  C07D417/12 ,  C07D513/04 ,  C07D487/10 ,  C07D239/80 ,  C07D401/14 ,  C07D237/34 ,  A61K31/416 ,  A61K31/55 ,  A61K31/454 ,  A61K31/517 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/7068 ,  C07D275/04

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.