公开(公告)号：US20140011796A1

公开(公告)日：2014-01-09

申请号：US14025688

申请日：2013-09-12

申请人： AMGEN INC.

发明人： Michael David BARTBERGER ,  Ana Gonzalez Buenrostro ,  Hilary Plake Beck ,  Xiaoqi Chen ,  Richard Victor Connors ,  Jeffrey Deignan ,  Jason Duquette ,  John Eksterwicz ,  Benjamin Fisher ,  Brian Matthew Fox ,  Jiasheng Fu ,  Zice Fu ,  Felix Gonzalez Lopez De Turiso ,  Michael William Gribble ,  Dann James Gustin ,  Julie Anne Heath ,  Xin Huang ,  Xianyun Jiao ,  Michael Johnson ,  Frank Kayser ,  David John Kopecky ,  Sujen Lai ,  Yihong Li ,  Zhihong Li ,  Jiwen Liu ,  Jonathan Dante Low ,  Brian Stuart Lucas ,  Zhihua Ma ,  Lawrence R. McGee ,  Joel McIntosh ,  Dustin McMinn ,  Julio Cesar Medina ,  Jeffrey Thomas Mihalic ,  Steven Howard Olson ,  Yosup Rew ,  Philip Marley Roveto ,  Daqing Sun ,  Xiaodong Wang ,  Yingcai Wang ,  Xuelei Yan ,  Ming Yu ,  Jiang Zhu

IPC分类号： C07D211/76 ,  C07D417/12 ,  C07D413/06 ,  C07D471/10 ,  C07D409/04 ,  C07D401/04 ,  C07D279/02 ,  C07D491/08 ,  C07D498/08 ,  C07D417/14 ,  C07D491/153 ,  C07D417/06 ,  C07D401/06 ,  C07D405/04

CPC分类号： C07D211/76 ,  C07D221/20 ,  C07D279/02 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D407/04 ,  C07D407/06 ,  C07D409/04 ,  C07D409/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/10 ,  C07D491/08 ,  C07D491/153 ,  C07D498/08 ,  C07D498/14 ,  C07D498/20

摘要： The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

公开(公告)号：US10988485B2

公开(公告)日：2021-04-27

申请号：US16407889

申请日：2019-05-09

申请人： Amgen Inc.

发明人： Ana Elena Minatti ,  Jonathan Dante Low ,  Ryan Paul Wurz ,  Brian Alan Lanman ,  Victor J. Cee ,  Michael D. Bartberger ,  Margaret Chu-Moyer

IPC分类号： C07D513/04 ,  A61K45/06 ,  C07K16/28

摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：US12054476B2

公开(公告)日：2024-08-06

申请号：US17551105

申请日：2021-12-14

申请人： AMGEN INC.

发明人： Nuria A. Tamayo ,  Abhisek Banerjee ,  James Alexander Brown ,  Michael J Frohn ,  Jian Jeffrey Chen ,  Kexue Li ,  Qingyian Liu ,  Jonathan Dante Low ,  Vu Ma ,  Liping H. Pettus ,  Mary Catherine Walton ,  Ana Elena Minatti ,  Matthew Paul Bourbeau ,  Lei Jia

IPC分类号： C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D419/14 ,  C07D491/107

CPC分类号： C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D419/14 ,  C07D491/107

摘要： Compounds of formula (I):




as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

公开(公告)号：US11236069B2

公开(公告)日：2022-02-01

申请号：US16724119

申请日：2019-12-20

申请人： AMGEN INC.

发明人： Nuria A. Tamayo ,  Abhisek Banerjee ,  Jian Jeffrey Chen ,  Jonathan Dante Low ,  Ana Elena Minatti ,  Matthew Paul Bourbeau

IPC分类号： C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14 ,  C07D419/14 ,  C07D491/107

摘要： Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.