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公开(公告)号：US06893437B2
公开(公告)日：2005-05-17
申请号：US10241183
申请日：2002-09-10
申请人： David K. Swanson , Huy D. Phan , Anant V. Hegde
发明人： David K. Swanson , Huy D. Phan , Anant V. Hegde
CPC分类号： A61B18/1492 , A61B2018/00065 , A61B2018/00214 , A61B2018/00238 , A61B2018/1472
摘要： An electrode assembly adapted to transmit electrical energy for ablating body tissue includes an expandable and collapsible non-compliant body made of a durable material and defining an interior adapted to receive a medium containing ions. The body includes a porous region, an electrode adapted to transmit electrical energy located in the interior of the body, a microporous membrane located on the porous region of the non-compliant body, and the microporous membrane is sized to pass ions contained in the medium without substantial medium perfusion therethrough, to thereby enable ionic transport of electrical energy from the ion-containing medium to the exterior of the electrode assembly to ablate body tissue.
摘要翻译： 适于传递用于烧蚀身体组织的电能的电极组件包括由耐用材料制成并且限定适于接收含有离子的介质的内部的可膨胀和可折叠的非柔顺体。 主体包括多孔区域，适于透射位于身体内部的电能的电极，位于非顺应性体的多孔区域上的微多孔膜，并且微多孔膜的尺寸设定为使包含在介质中的离子 无需通过其进行实质的介质灌注，从而使电能从电离离子的介质到电极组件的外部离子转运以烧蚀身体组织。
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公开(公告)号：US5725535A
公开(公告)日：1998-03-10
申请号：US717299
申请日：1996-09-20
CPC分类号： A61F2/958 , A61M25/1011 , A61M2025/1013
摘要： A multiple balloon catheter for use in a vessel of a patient and for use with an inflation/deflation device. A flexible elongate tubular member with proximal and distal extremities has a distal balloon mounted on the distal extremity of the flexible elongate tubular member. Coaxial inner and outer balloons are mounted on the distal extremity of the flexible elongate member proximal of the distal balloon. The flexible elongate tubular member has balloon inflation lumens therein in communication with the interiors of the distal balloon and the inner and outer coaxial balloons. A manifold is secured to the proximal extremity of the flexible elongate tubular member in communication with the inflation lumens and is adjusted to be coupled to the inflation/deflation device. Valves are carried by the inflation/deflation manifold for inflating the distal balloon in the inner and outer coaxial balloons one at a time or in unison without removal of the inflation/deflation device from the manifold.
摘要翻译： 一种用于患者血管并用于充气/放气装置的多气囊导管。 具有近端和远端的柔性细长管状构件具有安装在柔性细长管状构件的远端上的远端球囊。 同轴的内外球囊安装在远端球囊近端的柔性细长构件的远端上。 柔性细长管状构件具有与远侧气囊和内外同轴气囊的内部连通的球囊充气腔。 歧管固定到与膨胀腔连通的柔性细长管状构件的近端，并且被调节以联接到充气/放气装置。 阀通过充气/放气歧管携带，用于一次一个地或一致地充气内外同轴气囊中的远端球囊，而不从歧管中移除充气/放气装置。
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公开(公告)号：US08607797B2
公开(公告)日：2013-12-17
申请号：US12852374
申请日：2010-08-06
申请人： Kasey Kai-Chi Li , Anant V. Hegde
发明人： Kasey Kai-Chi Li , Anant V. Hegde
IPC分类号： A61F5/56
摘要： Airflow restriction systems are described herein which may be used to treat various disorders by creating expiratory positive airway pressure while providing for patient comfort regardless of the patient's anatomical variances. Such a device may be removably secured externally over the patient's nose rather than within the nasal passages to increase patient comfort. The restriction device may be secured, e.g., via an adhesive, to the patient and actuated via any number of mechanical or electromechanical mechanisms. Moreover, the restriction device may include one or more sensors to detect the patient's respiration activity such that the device may be actuated to correspond to the patient's exhalation and squeeze or otherwise constrict the nasal passages at least partially by pressing against the exterior surface of the nose to restrict the expiratory airflow.
摘要翻译： 本文描述了气流限制系统，其可以用于通过产生呼气气道正压来治疗各种疾病，同时提供患者的舒适性，而不管患者的解剖方差如何。 这样的装置可以可拆卸地固定在病人的鼻子上，而不是在鼻通道内，以增加患者的舒适度。 限制装置可以例如经由粘合剂固定到患者，并通过任何数量的机械或机电机构致动。 此外，限制装置可以包括一个或多个传感器以检测患者的呼吸活动，使得可以致动装置以对应于患者的呼气，并且至少部分地通过按压鼻子的外表面挤压或以其他方式收缩鼻通道 以限制呼气气流。
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14.发明授权Delivery tools for sleep disorders treatment implant and methods of implantation 失效用于睡眠障碍治疗植入物和植入方法的递送工具公开(公告)号：US07980248B2
公开(公告)日：2011-07-19
申请号：US12168820
申请日：2008-07-07
申请人： Anant V. Hegde , Kasey Kai-Chi Li , Phil Houle , Casidy Hallsten , Chris D. Owen
发明人： Anant V. Hegde , Kasey Kai-Chi Li , Phil Houle , Casidy Hallsten , Chris D. Owen
IPC分类号： A61F5/56
CPC分类号： A61F2/00 , A61B17/320016 , A61B17/3209 , A61B2017/248 , A61F5/56
摘要： Methods and tools are disclosed for inserting an implant device that treats snoring and apnea of a patient by altering the position of a soft palate. Methods and tools can make an incision in patient's soft and hard palate to create a cavity that can house the implant. The tools can have visually observable markings that can be aligned with the incision, thus controlling the depth of the cavity. A needle having an incision edge can be used to make an incision in patient's soft palate. The needle can be bent into a suitable longitudinal shape to allow easier access and visualization of the process. A blade that makes the cavity in the tissue can be housed inside a channel in the needle. The tools may have stoppers to prevent excessive extension and retraction of the blade thus preventing an excessive cavity depth. Some tools may also house the implant device, which may be implanted after the cavity is formed.
摘要翻译： 公开了用于插入通过改变软腭的位置来治疗患者的打鼾和呼吸暂停的植入装置的方法和工具。 方法和工具可以在病人的柔软和硬腭中形成切口，以创建可容纳植入物的腔体。 工具可以具有可与切口对准的视觉上可观察到的标记，从而控制腔的深度。 具有切口边缘的针可用于在患者的软腭中进行切口。 针可以弯曲成适当的纵向形状，以允许更容易地进入和可视化过程。 使得组织中的空腔可以容纳在针的通道内的刀片。 工具可以具有止动件以防止叶片的过度的伸展和缩回，从而防止过大的腔深度。 一些工具还可以容纳植入装置，其可以在腔形成之后植入。
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公开(公告)号：US07882842B2
公开(公告)日：2011-02-08
申请号：US11355927
申请日：2006-02-15
IPC分类号： A61B19/00
CPC分类号： A61F5/566 , A61B5/0031 , A61B5/1076 , A61B5/4818 , A61C7/00 , A61F2/00 , A61F5/56 , A61N1/0519 , A61N1/0546 , A61N1/0548 , A61N1/3601
摘要： An airway implant device for maintaining and/or creating an opening in air passageways is disclosed. Methods of using the device are also disclosed. The airway implant device comprises a deformable element to control the opening of an air passageway. Preferably the deformable element is an electroactive polymer element. Energizing of the electroactive polymer element provides support for the walls of an air passageway, when the walls collapse, and thus, completely or partially opens the air passageway. Some embodiments of the invention include a sensor capable of sensing the possible occurrence of an apneic event and activating the deformable element of the airway implant device. Methods of treating airway disorders such as sleep apnea and snoring with the airway implant device are disclosed herein.
摘要翻译： 公开了一种用于在空气通道中保持和/或形成开口的气道植入装置。 还公开了使用该装置的方法。 气道植入装置包括可变形元件以控制空气通道的开口。 优选地，可变形元件是电活性聚合物元件。 电活性聚合物元件的通电为空气通道的壁提供支撑，当壁崩溃时，从而完全或部分地打开空气通道。 本发明的一些实施例包括能够感测呼吸暂停事件的可能发生并激活气道植入装置的可变形元件的传感器。 本文公开了用气道植入装置处理呼吸道疾病如睡眠呼吸暂停和打鼾的方法。
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公开(公告)号：US20090173352A1
公开(公告)日：2009-07-09
申请号：US12261968
申请日：2008-10-30
申请人： Nikhil D. Bhat , Anant V. Hegde , Kasey Li , Matthew Goebel , HongPeng Wang , Ryan Woo
发明人： Nikhil D. Bhat , Anant V. Hegde , Kasey Li , Matthew Goebel , HongPeng Wang , Ryan Woo
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： The present invention provides an airway implant device having an electroactive polymer element, including: a composite layer having a polymer substrate and a biocompatible conductive material, wherein the composite layer also can be opposing surfaces; and a conductive polymer layer disposed on at least one of the opposing surfaces of the composite layer, wherein the implant device is adapted and configured to modulate an opening of an air passageway. Some embodiments include a housing designed to conform to the shape of the palate. Some embodiments include an attachment element to secure the device to tissue. Methods of treating airway disorders such as sleep apnea and snoring with the airway implant device are disclosed herein.
摘要翻译： 本发明提供一种具有电活性聚合物元件的气道植入装置，包括：具有聚合物基底和生物相容的导电材料的复合层，其中复合层也可以是相对的表面; 以及设置在所述复合层的至少一个相对表面上的导电聚合物层，其中所述植入装置适于和构造成调制空气通道的开口。 一些实施例包括设计成符合腭形状的外壳。 一些实施例包括用于将装置固定到组织的附接元件。 本文公开了用气道植入装置处理呼吸道疾病如睡眠呼吸暂停和打鼾的方法。
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公开(公告)号：US20090078274A1
公开(公告)日：2009-03-26
申请号：US12235536
申请日：2008-09-22
IPC分类号： A61F5/56
CPC分类号： A61F2/02 , A61B5/0031 , A61B5/076 , A61B5/1076 , A61B5/4818 , A61B5/682 , A61F5/566
摘要： Systems and methods for detecting an obstructive sleep apnea event are disclosed herein. The systems and methods may use an electrical output generating ionic polymer metal composite sensor attached to a region in an airway passage in an oral cavity. The electrical output may be wirelessly transmitted as a signal for indication of an obstructive sleep apnea event. The signal may be further analyzed for treatment of the obstructive sleep apnea event.
摘要翻译： 本文公开了用于检测阻塞性睡眠呼吸暂停事件的系统和方法。 系统和方法可以使用附着在口腔中的气道通道中的区域的电输出产生离子聚合物金属复合传感器。 电输出可以作为用于指示阻塞性睡眠呼吸暂停事件的信号被无线发送。 可以进一步分析该信号以治疗阻塞性睡眠呼吸暂停事件。
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18.发明申请Auto-Titration of Positive Airway Pressure Machine With Feedback From Implantable Sensor 有权自动滴定阳性气道压力机与植入式传感器反馈公开(公告)号：US20090078257A1
公开(公告)日：2009-03-26
申请号：US12235538
申请日：2008-09-22
IPC分类号： A61M16/00
CPC分类号： A61B5/076 , A61B5/0031 , A61B5/1076 , A61B5/415 , A61B5/4818 , A61B5/682 , A61F2/02 , A61F5/566
摘要： Systems and methods for detecting and treating an obstructive sleep apnea event are disclosed herein. The systems and methods may use an electrical output generating ionic polymer metal composite sensor attached to a region in an airway passage in an oral cavity. The electrical output may be wirelessly transmitted as a signal for indication of an obstructive sleep apnea event. The signal may be further analyzed by a positive airway pressure system for treatment of the obstructive sleep apnea event.
摘要翻译： 本文公开了用于检测和治疗阻塞性睡眠呼吸暂停事件的系统和方法。 系统和方法可以使用附着在口腔中的气道通道中的区域的电输出产生离子聚合物金属复合传感器。 电输出可以作为用于指示阻塞性睡眠呼吸暂停事件的信号被无线发送。 可以通过用于治疗阻塞性睡眠呼吸暂停事件的正气道压力系统进一步分析该信号。
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公开(公告)号：US20090038623A1
公开(公告)日：2009-02-12
申请号：US12192924
申请日：2008-08-15
申请人： John Michael Farbarik , Anthony Nguyen , Anant V. Hegde , Casidy Domingo , Charisse Yung , Nikhil D. Bhat , George Yoseung Choi
发明人： John Michael Farbarik , Anthony Nguyen , Anant V. Hegde , Casidy Domingo , Charisse Yung , Nikhil D. Bhat , George Yoseung Choi
摘要： An inductive power transfer system associated with an airway implant device is disclosed. A non-implanted portion of the system comprises a mouthpiece or retainer. The mouthpiece includes a power transfer circuit and a power source. The power transfer circuit includes a receive circuit configured to receive a first inductive power transfer from a charging device and to deliver a charging current to the power source. The power transfer circuit also includes a transmit circuit coupled to the power source. The transmit circuit is configured to provide a second inductive power transfer from the mouthpiece to the airway implant. Some embodiments of the non-implanted portion include a charge controller and a lithium polymer battery. Some embodiments of the charging device include a microcontroller for controlling operation of the charging device based on a proximity of the mouthpiece.
摘要翻译： 公开了一种与气道植入装置相关联的感应动力传递系统。 系统的非植入部分包括接口或保持器。 接口管包括电力传输电路和电源。 功率传输电路包括接收电路，其被配置为从充电装置接收第一感应功率传输并将充电电流传送到电源。 功率传输电路还包括耦合到电源的发射电路。 发射电路被配置为提供从接口管到气道植入物的第二感应功率传递。 非植入部分的一些实施例包括电荷控制器和锂聚合物电池。 充电装置的一些实施例包括用于基于接口件的接近来控制充电装置的操作的微控制器。
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20.发明授权Probe assembly for mapping and ablating pulmonary vein tissue and method of using same 失效用于测绘和消融肺静脉组织的探针组件及其使用方法公开(公告)号：US06640120B1
公开(公告)日：2003-10-28
申请号：US09684559
申请日：2000-10-05
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B2018/00065 , A61B2018/00214 , A61B2018/00238 , A61B2018/00267 , A61B2018/00375 , A61B2018/00839
摘要： The present invention relates to a probe assembly for mapping and ablating pulmonary vein tissue and method of using the same. The probe assembly includes an expandable and collapsible basket assembly having multiple splines. One or more of the splines carry one or more electrodes adapted to sense electrical activity in the pulmonary vein tissue. The basket assembly defines an interior, and a microporous expandable and collapsible body is disposed in the interior of the basket assembly and defines an interior adapted to receive a medium containing ions. An internal electrode is disposed within the interior of the body and is adapted to transmit electrical energy to the medium containing ions. The body includes at least one microporous region having a plurality of micropores therein sized to pass ions contained in the medium without substantial medium perfusion therethrough, enabling ionic transport of electrical energy from the internal electrode, through ion-containing medium to an exterior of the body to ablate pulmonary vein tissue. In other aspects of the invention, the microporous body may be replaced by a non-porous expandable and collapsible body that receives a fluid medium for expanding the non-porous body to exclude blood from the electrodes on the splines, or the probe assembly may not include any expandable and collapsible body in the basket assembly interior (one or more electrodes on splines sense electrical activity in the pulmonary vein tissue and ablate the pulmonary vein tissue).
摘要翻译： 本发明涉及用于测定和消融肺静脉组织的探针组件及其使用方法。 探针组件包括具有多个花键的可膨胀和可折叠的篮组件。 一个或多个花键携带一个或多个适于感测肺静脉组织中的电活动的电极。 筐组件限定内部，并且微孔可膨胀和可折叠主体设置在筐组件的内部并且限定适于接收含有离子的介质的内部。 内部电极设置在身体的内部，并且适于将电能传递到包含离子的介质。 主体包括至少一个微孔区域，其中具有多个微孔，其尺寸适于通过包含在介质中的离子而不需要大量介质灌注，从而能够将电能从内部电极通过含离子的介质离子输送到体外 消融肺静脉组织。 在本发明的其它方面，微孔体可以被接收用于膨胀无孔体的流体介质以排除来自花键上的电极的血液的无孔可扩张和可折叠体，或者探针组件可以不 在篮组件内部包括任何可膨胀和可折叠的主体（花键上的一个或多个电极感测肺静脉组织中的电活动并消融肺静脉组织）。
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