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11.
公开(公告)号:US20050148606A1
公开(公告)日:2005-07-07
申请号:US11070056
申请日:2005-03-02
IPC分类号: A61P3/10 , C07D473/00 , C07D473/02 , A61K31/522 , A61K31/55
CPC分类号: C07D473/00 , C07D473/02
摘要: The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV of formula I, pharmaceutical compositions comprising the compounds and the use of such compounds for and the manufacture of medicaments for treating diseases that are associated with proteins that are subject to inactivation by DPP-IV, such as type 2 diabetes and obesity.
摘要翻译: 本发明涉及式I的DPP-IV酶的治疗活性和选择性抑制剂,包含该化合物的药物组合物和这些化合物在制备用于治疗与被灭活的蛋白质相关的疾病的药物中的用途 通过DPP-IV,如2型糖尿病和肥胖。
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公开(公告)号:US20070213519A1
公开(公告)日:2007-09-13
申请号:US10507600
申请日:2003-03-14
申请人: Alex Gouliaev , Henrik Pedersen , Michael Godskesen , Tine Titilola Kronborg , Gitte Husemoen , Justin Ho , Jakob Felding , Christian Sams
发明人: Alex Gouliaev , Henrik Pedersen , Michael Godskesen , Tine Titilola Kronborg , Gitte Husemoen , Justin Ho , Jakob Felding , Christian Sams
IPC分类号: C07H21/00
CPC分类号: C07D405/04 , C07H21/00 , C12N15/1068 , C40B40/00
摘要: A building block having the dual capabilities of transferring genetic information and functional entity precursor to a recipient reactive group is disclosed. The building block may be used in the generation of a single complex or libraries of different complexes, wherein the complex comprises an encoded molecule linked to an encoding element. Libraries of complexes are useful in the quest for pharmaceutically active compounds.
摘要翻译: 公开了一种具有将遗传信息和功能性实体前体转移到受体反应性基团的双重能力的构建单元。 构建单元可以用于生成单个复合体或不同复合物的文库,其中复合物包含与编码元件连接的编码分子。 复合物库可用于寻求药物活性化合物。
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公开(公告)号:US20060099592A1
公开(公告)日:2006-05-11
申请号:US10525817
申请日:2003-10-30
申请人: Per-Ola Freskgard , Thomas Franch , Alex Gouliaev , Mikkel Lundorf , Jakob Felding , Eva Olsen , Anette Holtmann , Soeren Jakobsen , Christian Sams , Sanne Glad , Kim Jensen , Henrik Pedersen
发明人: Per-Ola Freskgard , Thomas Franch , Alex Gouliaev , Mikkel Lundorf , Jakob Felding , Eva Olsen , Anette Holtmann , Soeren Jakobsen , Christian Sams , Sanne Glad , Kim Jensen , Henrik Pedersen
CPC分类号: C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
摘要: Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactants(s) at the priming site using one or more enzymes.
摘要翻译: 公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法,其中包含化学反应位点的初生双功能复合物和用于酶标记添加的引发位点在化学反应位点与一个或多个 并且使用一种或多种酶提供标识启动位点处的反应物的各个标签。
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14.
公开(公告)号:US20050247001A1
公开(公告)日:2005-11-10
申请号:US10507829
申请日:2003-03-14
申请人: Alex Gouliaev , Henrik Pedersen , Kim Jensen , Mikkel Lundorf , Christian Sams , Jakob Felding , Michael Godskesen
发明人: Alex Gouliaev , Henrik Pedersen , Kim Jensen , Mikkel Lundorf , Christian Sams , Jakob Felding , Michael Godskesen
CPC分类号: C07D405/04 , C07H21/00 , C12N15/1034 , C12N15/1068 , C40B40/00
摘要: A building block having the dual capabilities of transferring genetic information and functional entity precursor to a recipient reactive group is disclosed. The building block may be used in the generation of a single complex or libraries of different complexes, wherein the complex comprises an encoded molecule linked to an encoding element. Libraries of complexes are useful in the quest for pharmaceutically active compounds.
摘要翻译: 公开了一种具有将遗传信息和功能性实体前体转移到受体反应性基团的双重能力的构建单元。 构建单元可以用于生成单个复合体或不同复合物的文库,其中复合物包含与编码元件连接的编码分子。 复合物库可用于寻求药物活性化合物。
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