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11.发明申请PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES 有权哌嗪化合物，它们作为MTOR激酶和PI3激酶抑制剂使用，以及它们的合成公开(公告)号：US20120134959A1
公开(公告)日：2012-05-31
申请号：US13264776
申请日：2010-04-15
申请人： Kevin Joseph Curran , Joshua Aaron Kaplan , David James Richard , Jeroen Cunera Verheijen , Arie Zask
发明人： Kevin Joseph Curran , Joshua Aaron Kaplan , David James Richard , Jeroen Cunera Verheijen , Arie Zask
IPC分类号： A61K31/5383 , A61K31/655 , A61K31/7068 , A61K31/675 , A61P35/00 , A61K31/7048 , A61K38/50 , A61K39/395 , A61K38/21 , C07D498/08 , A61K33/24
CPC分类号： C07D498/08
摘要： The invention relates to pyrimidine compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
摘要翻译： 本发明涉及式I的嘧啶化合物或其药学上可接受的盐，其中组成变量如本文所定义，包含该化合物的组合物，以及制备和使用该化合物的方法。
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![1H-PYRAZOLO[3,4-D]PYRIMIDINE, PURINE, 7H-PURIN-8(9H)-ONE, 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE, AND THIENO[3,2-D]PYRIMIDINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES](/abs-image/US/2009/07/30/US20090192176A1/abs.jpg.150x150.jpg)
12.发明申请1H-PYRAZOLO[3,4-D]PYRIMIDINE, PURINE, 7H-PURIN-8(9H)-ONE, 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE, AND THIENO[3,2-D]PYRIMIDINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES 审中-公开1H-吡唑并[3,4-D]吡嗪，嘌呤，7H-嘌呤-8（9H） - 酮，3H- [1,2,3]三唑并[4,5-D]吡嗪和噻吩并[3,2 -D]吡嗪化合物，它们作为mTOR激酶和PI3激酶抑制剂使用，以及它们的合成公开(公告)号：US20090192176A1
公开(公告)日：2009-07-30
申请号：US12361607
申请日：2009-01-29
申请人： Arie Zask , Christoph Martin Dehnhardt , Joshua Aaron Kaplan , Efren Guillermo Delos Santos , Aranapakam Mudumbai Venkatesan , Jeroen Cunera Verheijen
发明人： Arie Zask , Christoph Martin Dehnhardt , Joshua Aaron Kaplan , Efren Guillermo Delos Santos , Aranapakam Mudumbai Venkatesan , Jeroen Cunera Verheijen
IPC分类号： A61K31/519 , C07D487/04 , C07D495/04 , A61P35/00
CPC分类号： C07D487/04 , C07D513/04
摘要： The invention relates to 1H-pyrazolo[3,4-d]pyrimidine, purine, 7H-purin-8(9H)-one, 3H-[1,2,3]triazolo[4,5-d]pyrimidine, and thieno[3,2-d]pyrimidine compounds, compositions comprising the compounds, and methods for making and using the compounds.
摘要翻译： 本发明涉及1H-吡唑并[3,4-d]嘧啶嘌呤，7H-嘌呤-8（9H） - 酮，3H- [1,2,3]三唑并[4,5-d]嘧啶，噻吩并[ [3,2-d]嘧啶化合物，包含该化合物的组合物，以及制备和使用该化合物的方法。
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公开(公告)号：US08394829B2
公开(公告)日：2013-03-12
申请号：US13103577
申请日：2011-05-09
申请人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Jennifer Alissa Loyer-Drew , Stephane Perreault , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk K. Stevens , Josh Van Veldhuizen
发明人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Jennifer Alissa Loyer-Drew , Stephane Perreault , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk K. Stevens , Josh Van Veldhuizen
IPC分类号： C07D215/38 , A61K31/04
CPC分类号： C07D215/54 , C07D401/12 , C07D409/14 , C07D413/12
摘要： Provided are compounds of Formula I: wherein X is: R1 and R2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring, and all other variables are as defined herein, as well as their use in treating pulmonary inflammation or bronchoconstriction and compositions comprising and processes for preparing the same.
摘要翻译： 提供式I的化合物：其中X是：R 1和R 2与它们所连接的苯基一起可以形成双环稠合杂环，并且所有其它变量如本文所定义，以及它们在治疗肺部炎症中的用途 或支气管收缩剂及其组合物及其制备方法。
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公开(公告)号：US20130018050A1
公开(公告)日：2013-01-17
申请号：US13619792
申请日：2012-09-14
申请人： WILLIAM R. BAKER , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
发明人： WILLIAM R. BAKER , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
IPC分类号： C07D471/04 , A61K31/437 , A61K31/536 , A61P29/00 , A61P11/02 , A61P37/08 , A61P11/00 , A61P11/08 , A61P11/06 , A61P11/10 , A61K31/4709 , A61P31/00
CPC分类号： C07D471/04
摘要： This invention provides compounds of the formula: wherein X is wherein R1 and R2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring and all other variables are as defined herein, their use in pulmonary inflammation or bronchoconstriction therapy and compositions comprising and processes for preparing the same are provided.
摘要翻译： 本发明提供下式的化合物：其中X是其中R 1和R 2与它们所连接的苯基一起可以形成双环稠合杂环，所有其它变量如本文所定义，它们在肺部炎症或支气管收缩治疗中的用途，以及 提供了组合物及其制备方法。
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公开(公告)号：US08450490B2
公开(公告)日：2013-05-28
申请号：US13619792
申请日：2012-09-14
申请人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
发明人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
IPC分类号： C07D513/02
CPC分类号： C07D471/04
摘要： This invention provides compounds of the formula: wherein X is wherein R1 and R2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring and all other variables are as defined herein, their use in pulmonary inflammation or bronchoconstriction therapy and compositions comprising and processes for preparing the same are provided.
摘要翻译： 本发明提供下式的化合物：其中X是其中R 1和R 2与它们所连接的苯基一起可以形成双环稠合杂环，所有其它变量如本文所定义，它们在肺部炎症或支气管收缩治疗中的用途，以及 提供了组合物及其制备方法。
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公开(公告)号：US20130012504A1
公开(公告)日：2013-01-10
申请号：US13619636
申请日：2012-09-14
申请人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Jennifer Alissa Loyer-Drew , Stephane Perreault , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
发明人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Jennifer Alissa Loyer-Drew , Stephane Perreault , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
IPC分类号： C07D215/54 , C07D401/14 , A61K31/496 , C07D413/12 , A61K31/538 , A61K31/4706 , C07D409/14 , A61P29/00 , A61P31/00 , A61P37/08 , A61P11/00 , A61P11/08 , A61P11/06 , A61P11/10 , A61P11/02 , A61K31/4709
CPC分类号： C07D215/54 , C07D401/12 , C07D409/14 , C07D413/12
摘要： Provided are compounds of Formula I: R1 and R2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring, and all other variables are as defined herein, as well as their use in treating pulmonary inflammation or bronchoconstriction and compositions comprising and processes for preparing the same.
摘要翻译： 提供式I化合物：R 1和R 2与它们所连接的苯基一起可以形成双环稠合杂环，并且所有其它变量如本文所定义，以及它们在治疗肺部炎症或支气管收缩和组合物中的用途 包括及其制备方法。
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公开(公告)号：US20110275622A1
公开(公告)日：2011-11-10
申请号：US13103577
申请日：2011-05-09
申请人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Jennifer Alissa Loyer-Drew , Stephane Perreault , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
发明人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Jennifer Alissa Loyer-Drew , Stephane Perreault , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
IPC分类号： A61K31/4709 , C07D401/14 , C07D413/12 , A61K31/496 , A61K31/538 , A61P29/00 , A61K31/475 , A61P11/00 , A61P11/06 , A61P11/08 , A61P3/00 , C07D215/54 , A61K31/4706
CPC分类号： C07D215/54 , C07D401/12 , C07D409/14 , C07D413/12
摘要： Provided are compounds of Formula I: wherein X is: R1 and R2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring, and all other variables are as defined herein, as well as their use in treating pulmonary inflammation or bronchoconstriction and compositions comprising and processes for preparing the same.
摘要翻译： 提供式I的化合物：其中X是：R 1和R 2与它们所连接的苯基一起可以形成双环稠合杂环，并且所有其它变量如本文所定义，以及它们在治疗肺部炎症中的用途 或支气管收缩剂及其组合物及其制备方法。
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公开(公告)号：US20150344473A1
公开(公告)日：2015-12-03
申请号：US14728562
申请日：2015-06-02
申请人： Zhimin Du , Juan Arnaldo Guerrero , Joshua Aaron Kaplan , John Edward Knox, JR. , Devan Naduthambi , Barton W. Phillips , Chandrasekar Venkataramani , Peiyuan Wang , William J. Watkins , Jeff Zablocki
发明人： Zhimin Du , Juan Arnaldo Guerrero , Joshua Aaron Kaplan , John Edward Knox, JR. , Devan Naduthambi , Barton W. Phillips , Chandrasekar Venkataramani , Peiyuan Wang , William J. Watkins , Jeff Zablocki
IPC分类号： C07D471/04 , C07D487/04 , C07D473/00 , C07D519/00
CPC分类号： C07D471/04 , C07D473/00 , C07D487/04
摘要： Compounds having the following formula (I) and methods of their use and preparation are disclosed:
摘要翻译： 公开了具有下式（I）的化合物及其使用和制备方法：
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公开(公告)号：US08367829B2
公开(公告)日：2013-02-05
申请号：US13103598
申请日：2011-05-09
申请人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
发明人： William R. Baker , Shaopei Cai , Joshua Aaron Kaplan , Musong Kim , Gary Phillips , Lafe J. Purvis, II , Marcin Stasiak , Kirk L. Stevens , Josh Van Veldhuizen
IPC分类号： C07D513/02
CPC分类号： C07D471/04
摘要： This invention provides compounds of the formula: wherein X is wherein R1 and R2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring and all other variables are as defined herein, their use in pulmonary inflammation or bronchoconstriction therapy and compositions comprising and processes for preparing the same are provided.
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