专利检索 ap:("Zhimin Du" OR "Juan Arnaldo Guerrero" OR "Joshua Aaron Kaplan" OR "John Edward Knox, JR." OR "Devan Naduthambi" OR "Barton W. Phillips" OR "Chandrasekar Venkataramani" OR "Peiyuan Wang" OR "William J. Watkins" OR "Jeff Zablocki") AND inv:"William J. Watkins" 第 1 页

1.

发明申请
TANK-BINDING KINASE INHIBITOR COMPOUNDS 审中-公开
标题翻译： K ING ING ING。。。。。。

公开(公告)号：US20150344473A1

公开(公告)日：2015-12-03

申请号：US14728562

申请日：2015-06-02

申请人： Zhimin Du , Juan Arnaldo Guerrero , Joshua Aaron Kaplan , John Edward Knox, JR. , Devan Naduthambi , Barton W. Phillips , Chandrasekar Venkataramani , Peiyuan Wang , William J. Watkins , Jeff Zablocki

发明人： Zhimin Du , Juan Arnaldo Guerrero , Joshua Aaron Kaplan , John Edward Knox, JR. , Devan Naduthambi , Barton W. Phillips , Chandrasekar Venkataramani , Peiyuan Wang , William J. Watkins , Jeff Zablocki

IPC分类号： C07D471/04 , C07D487/04 , C07D473/00 , C07D519/00

CPC分类号： C07D471/04 , C07D473/00 , C07D487/04

摘要： Compounds having the following formula (I) and methods of their use and preparation are disclosed:

摘要翻译： 公开了具有下式（I）的化合物及其使用和制备方法：

2.

发明公开
THERAPEUTIC COMPOUNDS FOR HIV VIRUS INFECTION 审中-公开

公开(公告)号：US20230203071A1

公开(公告)日：2023-06-29

申请号：US18061127

申请日：2022-12-02

申请人： Zhimin Du , Julie Farand , Tezcan Guney , Darryl Kato , John O. Link , James B.C. Mack , Dong Min Mun , William J. Watkins , Jennifer R. Zhang

发明人： Zhimin Du , Julie Farand , Tezcan Guney , Darryl Kato , John O. Link , James B.C. Mack , Dong Min Mun , William J. Watkins , Jennifer R. Zhang

IPC分类号： C07F9/6503 , C07D401/14 , A61K45/06

CPC分类号： C07F9/65038 , C07D401/14 , A61K45/06

摘要： The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.

3.

发明申请
ANTIVIRAL COMPOUNDS 有权

公开(公告)号：US20140249074A1

公开(公告)日：2014-09-04

申请号：US14280478

申请日：2014-05-16

申请人： Elizabeth M. Bacon , Eda Canales , Aesop Cho , Jeromy J. Cottell , Manoj C. Desai , Michael Graupe , Hongyan Guo , Randall L. Halcomb , Darryl Kato , Choung U. Kim , Thorsten A. Kirschberg , Evan S. Krygowski , Scott E. Lazerwith , John O. Link , Hongtao Liu , Qi Liu , Richard L. Mackman , Michael L. Mitchell , Jay P. Parrish , Hyung-Jung Pyun , Joseph H. Saugier , Scott D. Schroeder , Jianyu Sun , James G. Taylor , James D. Trenkle , Winston C. Tse , Randall W. Vivian , William J. Watkins , Lianhong Xu

发明人： Elizabeth M. Bacon , Eda Canales , Aesop Cho , Jeromy J. Cottell , Manoj C. Desai , Michael Graupe , Hongyan Guo , Randall L. Halcomb , Darryl Kato , Choung U. Kim , Thorsten A. Kirschberg , Evan S. Krygowski , Scott E. Lazerwith , John O. Link , Hongtao Liu , Qi Liu , Richard L. Mackman , Michael L. Mitchell , Jay P. Parrish , Hyung-Jung Pyun , Joseph H. Saugier , Scott D. Schroeder , Jianyu Sun , James G. Taylor , James D. Trenkle , Winston C. Tse , Randall W. Vivian , William J. Watkins , Lianhong Xu

IPC分类号： A61K31/4184 , A61K45/06

CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025

摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

4.

发明授权
Pyrido(3,2-d)pyridmidines useful for treating viral infections 有权
标题翻译：吡啶（3,2-d）哒嗪可用于治疗病毒感染

公开(公告)号：US08637531B2

公开(公告)日：2014-01-28

申请号：US12519500

申请日：2007-12-24

申请人： Steven S. Bondy , William J. Watkins , Lee S. Chong , Piet Andre Maurits Maria Herdewijn , Steven Cesar Alfons De Jonghe

发明人： Steven S. Bondy , William J. Watkins , Lee S. Chong , Piet Andre Maurits Maria Herdewijn , Steven Cesar Alfons De Jonghe

IPC分类号： A01N43/90 , A61K31/519 , C07D471/00 , C07D487/00

CPC分类号： C07D471/04

摘要： This invention provides pyrido(3,2-d)pyrimidine derivatives represented by the structural formula (I), wherein: R1 is amino, R4 is hydrogen, and R2 and R3 together provide a specific substitution pattern, pharmaceutical acceptable addition salts, stereochemical isomeric forms, N-oxides, solvates and pro-drugs thereof, are useful in the treatment of hepatitis C.

摘要翻译： 本发明提供由结构式（I）表示的吡啶并（3,2-d）嘧啶衍生物，其中：R 1为氨基，R 4为氢，R 2和R 3一起提供特定取代模式，药学上可接受的加成盐，立体化学异构体形式，N-氧化物，溶剂合物和其前体药物可用于治疗丙型肝炎。

5.

发明授权
2,4,6-trisubstituted pyrido(3,2-d)pyrimidines useful for treating viral infections 有权
标题翻译： 2,4,6-三取代吡啶并（3,2-d）嘧啶可用于治疗病毒感染

公开(公告)号：US08536187B2

公开(公告)日：2013-09-17

申请号：US12996110

申请日：2009-07-01

申请人： Eda Canales , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael L. Mitchell , William J. Watkins , Jennifer R. Zhang

发明人： Eda Canales , Lee S. Chong , Michael O' Neil Hanrahan Clarke , Scott E. Lazerwith , Willard Lew , Qi Liu , Michael L. Mitchell , William J. Watkins , Jennifer R. Zhang

IPC分类号： A01N43/90 , A61K31/519 , C07D487/00

CPC分类号： C07D471/04

摘要： Pyrido(3,2-d)pyrimidine derivatives represented by the structural formula (Ia): wherein, R1, R2 and R3 are defined herein, pharmaceutical acceptable addition salts, stereochemical isomeric forms, N-oxides, solvates and pro-drugs thereof, for use in the treatment of hepatitis C.

摘要翻译： 由结构式（Ia）表示的吡啶并（3,2-d）嘧啶衍生物：其中R1，R2和R3如本文所定义，药学上可接受的加成盐，立体化学异构形式，N-氧化物，溶剂化物和其前体药物，用于治疗丙型肝炎。

6.

发明授权
Inhibitors of Flaviviridae viruses 有权

公开(公告)号：US08501714B2

公开(公告)日：2013-08-06

申请号：US13392467

申请日：2010-09-07

申请人： Aesop Cho , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Choung U. Kim , Qi Liu , William J. Watkins , Jennifer R. Zhang

发明人： Aesop Cho , Lee S. Chong , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Choung U. Kim , Qi Liu , William J. Watkins , Jennifer R. Zhang

IPC分类号： A61K31/67 , A61K31/675 , C07F9/6558 , C07F9/6553

CPC分类号： C07F9/655345 , A61K31/662 , A61K31/67 , A61K31/675 , A61K31/683 , A61K45/06 , C07F9/65586 , C07F9/6561 , C07F9/65681

摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

7.

发明授权
Method and compositions for treating hematological malignancies 有权
标题翻译：用于治疗血液恶性肿瘤的方法和组合物

公开(公告)号：US08435969B2

公开(公告)日：2013-05-07

申请号：US13070179

申请日：2011-03-23

申请人： Adrian S. Ray , Daniel B. Tumas , Hans Reiser , William J. Watkins , William A. Lee , Lee S. Chong

发明人： Adrian S. Ray , Daniel B. Tumas , Hans Reiser , William J. Watkins , William A. Lee , Lee S. Chong

IPC分类号： A61K31/675 , C07F9/6561

CPC分类号： C07F9/65616

摘要： A compound of formula 1 and/or its salts, tautomers or solvates is used to treat hematological malignancies. In an embodiment, an organic acid salt of compound 1 is provided for general use in treatment of neoplasms, and in a further embodiment the salt is stabilized with carbohydrate.

摘要翻译： 式1化合物和/或其盐，互变异构体或溶剂合物用于治疗血液恶性肿瘤。在一个实施方案中，提供化合物1的有机酸盐，用于一般用于治疗赘生物，并且在另一个实施方案中，所述盐用碳水化合物稳定。

8.

发明申请
INHIBITORS OF FLAVIVIRIDAE VIRUSES 有权
标题翻译： FLAVIVIRIDAE病毒的抑制剂

公开(公告)号：US20130052161A1

公开(公告)日：2013-02-28

申请号：US13549130

申请日：2012-07-13

申请人： William J. Watkins

发明人： William J. Watkins

IPC分类号： C07D333/38 , A61P31/14 , A61K31/7056 , A61K31/381 , A61K38/21

CPC分类号： C07D333/40

摘要： Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections (e.g. hepatitis C infections), particularly drug resistant Flaviviridae virus infections.

摘要翻译： 提供式I化合物及其药学上可接受的盐和酯。提供的化合物，组合物和方法可用于治疗黄病毒科病毒感染（例如丙型肝炎感染），特别是耐药性黄病毒科病毒感染。