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公开(公告)号：US08580765B2
公开(公告)日：2013-11-12
申请号：US13609614
申请日：2012-09-11
CPC分类号： A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/20 , Y02A50/463
摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
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公开(公告)号：US20100298257A1
公开(公告)日：2010-11-25
申请号：US12783680
申请日：2010-05-20
申请人： BRUCE ROSS , MICHAEL JOSEPH SOFIA , GANAPATI REDDY PAMULAPATI , SUGUNA RACHAKONDA , HAI-REN ZHANG , BYOUNG-KWON CHUN , PEIYUAN WANG
发明人： BRUCE ROSS , MICHAEL JOSEPH SOFIA , GANAPATI REDDY PAMULAPATI , SUGUNA RACHAKONDA , HAI-REN ZHANG , BYOUNG-KWON CHUN , PEIYUAN WANG
IPC分类号： A61K31/7072 , C07H19/10 , C07H19/06 , C07F9/24 , A61P31/14 , A61P31/12 , A61P31/16 , G01N30/02 , G01N23/207
CPC分类号： C07H19/10 , A61K31/7072 , A61K31/716 , A61K45/00 , C07F9/24 , C07F9/242 , C07F9/65586 , C07H1/00 , C07H17/02 , Y02A50/463 , Y02P20/55
摘要： Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.
摘要翻译： 本文公开了核苷氨基磷酸酯及其作为治疗病毒性疾病的药剂的用途。 这些化合物是RNA依赖性5 RNA病毒复制的抑制剂，可用作HCV NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和用于治疗哺乳动物的丙型肝炎感染。
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公开(公告)号：US20070197463A1
公开(公告)日：2007-08-23
申请号：US11635898
申请日：2006-12-08
申请人： Byoung-Kwon Chun , Jeremy Clark , Keshab Sarma , Peiyuan Wang
发明人： Byoung-Kwon Chun , Jeremy Clark , Keshab Sarma , Peiyuan Wang
IPC分类号： A61K31/7072 , C07H19/12
摘要： Compounds having the formula I wherein R1 is as herein defined are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis replication, and processes for making the compounds of formula I
摘要翻译： 具有式I的化合物，其中R 1如本文所定义，是丙型肝炎病毒NS5b聚合酶抑制剂。 还公开了抑制肝炎复制的组合物和方法，以及制备式I化合物的方法
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4.发明授权Preparation of 2′-fluoro-2′-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives 有权2'-氟-2'-烷基取代或其它任选取代的呋喃核糖嘧啶嘧啶和嘌呤及其衍生物的制备公开(公告)号：US08492539B2
公开(公告)日：2013-07-23
申请号：US11225425
申请日：2005-09-13
申请人： Byoung-Kwon Chun , Peiyuan Wang , Jinfa Du , Suguna Rachakonda
发明人： Byoung-Kwon Chun , Peiyuan Wang , Jinfa Du , Suguna Rachakonda
IPC分类号： C07H1/00 , C07H3/00 , C07H19/00 , C07H21/00 , C07D307/00
CPC分类号： C07D411/04 , A61K31/7072 , C07D307/20 , C07D307/33 , C07D317/30 , C07D405/04 , C07D407/04 , C07H15/203 , C07H19/06
摘要： The present invention provides (i) processes for preparing a 2′-deoxy-2′-fluoro-2′-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2′-deoxy-2′-fluoro-2′-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
摘要翻译： 本发明提供（i）制备2'-脱氧-2'-氟-2'-甲基-D-核糖内酯衍生物的方法，（ii）具有有效抗HCV活性的中间体内酯转化为核苷及其类似物 ，和（iii）从预先形成的，优选天然存在的核苷制备含有2'-脱氧-2'-氟-2'-C-methyl-β-D-呋喃核糖核苷的抗HCV核苷的方法。
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![Compounds with the bicyclo[4.2.1]nonane system for the treatment of Flaviviridae infections](/abs-image/US/2012/01/10/US08093380B2/abs.jpg.150x150.jpg)
5.发明授权Compounds with the bicyclo[4.2.1]nonane system for the treatment of Flaviviridae infections 失效具有双环[4.2.1]壬烷体系用于治疗黄病毒科感染的化合物公开(公告)号：US08093380B2
公开(公告)日：2012-01-10
申请号：US10632997
申请日：2003-08-01
申请人： Peiyuan Wang , Lieven J. Stuyver , Kyoichi A. Watanabe , Abdalla Hassan , Byoung-Kwon Chun , Laurent Hollecker
发明人： Peiyuan Wang , Lieven J. Stuyver , Kyoichi A. Watanabe , Abdalla Hassan , Byoung-Kwon Chun , Laurent Hollecker
IPC分类号： C07D403/00 , C07D405/00
CPC分类号： C07H19/167 , A61K31/513 , A61K31/553 , A61K31/58 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K38/2066 , A61K38/21 , C07D487/16 , C07D498/22 , C07H9/06 , A61K2300/00
摘要： The disclosed invention is a bicyclo[4.2.1]nonane and its pharmaceutically acceptable salt or prodrug, and its composition and method of use to treat Flaviviridae (Hepacivirus, Flavivirus, and Pestivirus) infections in a host, including animals, and especially humans.
摘要翻译： 所公开的发明是双环[4.2.1]壬烷及其药学上可接受的盐或前药，以及其在宿主（包括动物，特别是人）中治疗黄病毒（hepacivirus，Flavivirus，and Pestivirus））感染的组合物和方法。
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公开(公告)号：US20110257122A1
公开(公告)日：2011-10-20
申请号：US13099671
申请日：2011-05-03
申请人： Michael Joseph Sofia , Jinfa Du , Peiyuan Wang
发明人： Michael Joseph Sofia , Jinfa Du , Peiyuan Wang
IPC分类号： A61K31/7076 , A61P31/14 , C07H19/207 , C07H19/10 , A61K31/7068
CPC分类号： A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/20 , Y02A50/463
摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
摘要翻译： 本文公开了用于治疗哺乳动物病毒感染的核苷衍生物的氨基磷酸酯前药，哺乳动物是由以下结构表示的化合物，其立体异构体，盐（酸或碱加成盐），水合物，溶剂合物或结晶形式：也 披露了使用式I化合物制备各种方法的处理方法，用途和方法。
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公开(公告)号：US07754699B2
公开(公告)日：2010-07-13
申请号：US11635898
申请日：2006-12-08
申请人： Byoung-Kwon Chun , Jeremy Clark , Keshab Sarma , Peiyuan Wang
发明人： Byoung-Kwon Chun , Jeremy Clark , Keshab Sarma , Peiyuan Wang
摘要： Compounds having the formula I wherein R1 is as herein defined are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis replication, and processes for making the compounds of formula I
摘要翻译： 具有式I的化合物，其中R 1如本文所定义是丙型肝炎病毒NS5b聚合酶抑制剂。 还公开了抑制肝炎复制的组合物和方法，以及制备式I化合物的方法
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公开(公告)号：US20170253584A1
公开(公告)日：2017-09-07
申请号：US15425198
申请日：2017-02-06
申请人： Byoung Kwon Chun , Jinfa Du , Suguna Rachakonda , Peiyuan Wang
发明人： Byoung Kwon Chun , Jinfa Du , Suguna Rachakonda , Peiyuan Wang
IPC分类号： C07D411/04 , C07D307/20 , C07D307/33 , C07D317/30 , C07D405/04 , C07H19/06 , C07H15/203 , A61K31/7072 , C07D407/04
摘要： The present invention provides (i) processes for preparing a 2′-deoxy-2′-fluoro-2′-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2′-deoxy-2′-fluoro-2′-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
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公开(公告)号：US08642756B2
公开(公告)日：2014-02-04
申请号：US12783680
申请日：2010-05-20
申请人： Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Suguna Rachakonda , Hai-Ren Zhang , Byoung-Kwon Chun , Peiyuan Wang
发明人： Bruce Ross , Michael Joseph Sofia , Ganapati Reddy Pamulapati , Suguna Rachakonda , Hai-Ren Zhang , Byoung-Kwon Chun , Peiyuan Wang
IPC分类号： A61K31/716 , C07H19/10
CPC分类号： C07H19/10 , A61K31/7072 , A61K31/716 , A61K45/00 , C07F9/24 , C07F9/242 , C07F9/65586 , C07H1/00 , C07H17/02 , Y02A50/463 , Y02P20/55
摘要： Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.
摘要翻译： 本文公开了核苷氨基磷酸酯及其作为治疗病毒性疾病的药剂的用途。 这些化合物是RNA依赖性5 RNA病毒复制的抑制剂，可用作HCV NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和用于治疗哺乳动物的丙型肝炎感染。
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公开(公告)号：US08334270B2
公开(公告)日：2012-12-18
申请号：US13099671
申请日：2011-05-03
CPC分类号： A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/073 , C07H19/10 , C07H19/20 , Y02A50/463
摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
摘要翻译： 本文公开了用于治疗哺乳动物病毒感染的核苷衍生物的氨基磷酸酯前药，哺乳动物是由以下结构表示的化合物，其立体异构体，盐（酸或碱加成盐），水合物，溶剂合物或结晶形式：也 披露了使用式I化合物制备各种方法的处理方法，用途和方法。
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