公开(公告)号：US10125167B2

公开(公告)日：2018-11-13

申请号：US15368178

申请日：2016-12-02

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Chris Diehnelt ,  Stephen Johnston ,  Pamela Hall

IPC: C07K7/06 ,  A61K38/08 ,  A61K31/43 ,  A61K31/431 ,  C07K7/08 ,  A61K38/00

Abstract: Provided herein are compounds and compositions having antibiotic activity against methicillin resistant Staphylococcus aureus (MRSA). In particular, provided herein is a synbody that bactericidal against multiple strains of MRSA and that can be used in conjugation with currently approved β-lactam antibiotics to treat MRSA strains having resistance to β-lactam treatment. Also provided are methods of using the compounds and compositions for treating, preventing or reducing MRSA infections.

公开(公告)号：US20170158736A1

公开(公告)日：2017-06-08

申请号：US15368178

申请日：2016-12-02

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Chris Diehnelt ,  Stephen Johnston ,  Pamela Hall

IPC: C07K7/06 ,  A61K31/43 ,  A61K38/08

CPC classification number: C07K7/06 ,  A61K31/43 ,  A61K31/431 ,  A61K38/00 ,  A61K38/08 ,  C07K7/08 ,  C07K2318/00 ,  A61K2300/00

Abstract: Provided herein are compounds and compositions having antibiotic activity against methicillin resistant Staphylococcus aureus (MRSA). In particular, provided herein is a synbody that bactericidal against multiple strains of MRSA and that can be used in conjugation with currently approved β-lactam antibiotics to treat MRSA strains having resistance to β-lactam treatment. Also provided are methods of using the compounds and compositions for treating, preventing or reducing MRSA infections.

公开(公告)号：US12025615B2

公开(公告)日：2024-07-02

申请号：US16647434

申请日：2018-09-13

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Stephen Johnston

IPC: G01N31/00 ,  C07K16/28 ,  G01N33/53 ,  G01N33/543 ,  G01N33/574 ,  G16B40/00 ,  G16H10/40 ,  G16H20/00 ,  G16H50/00 ,  G16H50/20 ,  G16H50/30 ,  G16H50/70 ,  C07K14/705 ,  G16H10/60

CPC classification number: G01N33/574 ,  C07K16/2818 ,  C07K16/2827 ,  G01N33/543 ,  G16B40/00 ,  G16H10/40 ,  G16H20/00 ,  G16H50/00 ,  G16H50/20 ,  G16H50/30 ,  G16H50/70 ,  C07K14/70503 ,  C07K14/70521 ,  C07K16/2803 ,  C07K2317/76 ,  G01N2800/52 ,  G01N2800/60 ,  G16H10/60

Abstract: Provided herein are methods for classifying how a subject having a cancer will respond to immunotherapeutic (IT) therapy based on the subject's immunosignature or frameshift signature. Also provided herein are methods for classifying a subject having a cancer as having a good prognosis or a poor prognosis based on the subject's immunosignature or frameshift signature.

公开(公告)号：US11067582B2

公开(公告)日：2021-07-20

申请号：US16748723

申请日：2020-01-21

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Neal Woodbury ,  Stephen Johnston ,  Phillip Stafford

IPC: G01N33/68

Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.

公开(公告)号：US10578623B2

公开(公告)日：2020-03-03

申请号：US15991892

申请日：2018-05-29

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Neal Woodbury ,  Stephen Johnston ,  Phillip Stafford

IPC: G01N33/68

Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.

公开(公告)号：US10006919B2

公开(公告)日：2018-06-26

申请号：US14773750

申请日：2014-03-14

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Neal Woodbury ,  Stephen Johnston ,  Phillip Stafford

IPC: G01N33/68

CPC classification number: G01N33/6845

Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.

公开(公告)号：US11971410B2

公开(公告)日：2024-04-30

申请号：US17651235

申请日：2022-02-15

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Stephen Johnston

IPC: G01N31/00 ,  C07K16/28 ,  G01N33/53 ,  G01N33/543 ,  G01N33/574 ,  G16B40/00 ,  G16H10/40 ,  G16H20/00 ,  G16H50/00 ,  G16H50/20 ,  G16H50/30 ,  G16H50/70 ,  C07K14/705 ,  G16H10/60

CPC classification number: G01N33/574 ,  C07K16/2818 ,  C07K16/2827 ,  G01N33/543 ,  G16B40/00 ,  G16H10/40 ,  G16H20/00 ,  G16H50/00 ,  G16H50/20 ,  G16H50/30 ,  G16H50/70 ,  C07K14/70503 ,  C07K14/70521 ,  C07K16/2803 ,  C07K2317/76 ,  G01N2800/52 ,  G01N2800/60 ,  G16H10/60

Abstract: Provided herein are methods for classifying how a subject having a cancer will respond to immunotherapeutic (IT) therapy based on the subject's immunosignature or frameshift signature. Also provided herein are methods for classifying a subject having a cancer as having a good prognosis or a poor prognosis based on the subject's immunosignature or frameshift signature.