-
公开(公告)号：US20210220361A1
公开(公告)日：2021-07-22
申请号：US17133094
申请日：2020-12-23
Applicant: ARRAY BIOPHARMA INC.
Inventor： David Shank Fry , Christopher M. Lindemann , Michael Preigh , Corey Jay Bloom , Christopher Donovan Craig , Devon Brevard Dubose , Jeff Gautschi , Dan Smithey
Abstract: A solid dispersion of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and processes for preparing the solid dispersion are provided herein. Also, a pharmaceutical composition comprising a solid dispersion of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and uses thereof are provided herein.
-
公开(公告)号：US20190275043A1
公开(公告)日：2019-09-12
申请号：US16353951
申请日：2019-03-14
Applicant: Array BioPharma Inc.
Inventor： David Shank Fry , Christopher M. Lindemann , Michael Preigh , Corey Jay Bloom , Christopher Donovan Craig , Devon Brevard Dubose , Jeff Gautschi , Dan Smithey
Abstract: A solid dispersion of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and processes for preparing the solid dispersion are provided herein. Also, a pharmaceutical composition comprising a solid dispersion of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and uses thereof are provided herein.
-
公开(公告)号：US20160251350A1
公开(公告)日：2016-09-01
申请号：US15054611
申请日：2016-02-26
Applicant: Genentech, Inc. , Array Biopharma Inc.
Inventor： Jeffrey Stults , Christopher M. Lindemann , Keith L. Spencer , Weidong Liu , Joseph Lubach
IPC: C07D471/04 , A61K45/06 , A61K31/437
CPC classification number: C07D471/04 , A61K31/437 , A61K45/06
Abstract: Disclosed are crystalline forms of (R)—N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, and salts, solvates, and hydrates thereof, and pharmaceutical compositions, formulations and a process of manufacturing thereof.
Abstract translation: 公开了（R）-N-（4-（3-氨基哌啶-1-基）-5-溴-1H-吡咯并[2,3-b]吡啶-3-基）环丙烷甲酰胺和盐，溶剂化物的结晶形式 及其水合物，以及药物组合物，制剂及其制造方法。
-
14.发明申请POLYMORPHS OF ARRY-380, A SELECTIVE HER 2 INHIBITOR AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权ARRY-380的多聚体，选择性的2抑制剂和含有它们的药物组合物公开(公告)号：US20160175309A1
公开(公告)日：2016-06-23
申请号：US14923172
申请日：2015-10-26
Applicant: Array BioPharma Inc.
Inventor： Donald T. Corson , Christopher M. Lindemann , Daniel J. Watson
IPC: A61K31/517 , A61K45/06
CPC classification number: A61K31/517 , A61K31/437 , A61K45/06 , A61P35/00 , C07D471/04
Abstract: Polymorphs of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine are provided herein. Processes for preparing the polymorphs and pharmaceutical composition comprising the polymorphs are also disclosed.
Abstract translation: N 4 - （4 - （[1,2,4]三唑并[1,5-a]吡啶-7-基氧基）-3-甲基苯基）-N6-（4,4-二甲基-4,5-二氢恶唑-2-基） 吡啶-2-基）喹唑啉-4,6-二胺。 还公开了制备多晶型物的方法和包含多晶型物的药物组合物。
-
15.发明授权公开(公告)号：US10765678B2
公开(公告)日：2020-09-08
申请号：US16169937
申请日：2018-10-24
Applicant: Array BioPharma Inc.
Inventor： Donald T. Corson , Christopher M. Lindemann , Daniel J. Watson
IPC: C07D471/04 , A61K31/437 , A61K31/517 , A61P35/00 , A61K45/06
Abstract: Polymorphs of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine are provided herein. Processes for preparing the polymorphs and pharmaceutical composition comprising the polymorphs are also disclosed.
-
Patent Agency Ranking
16.发明授权公开(公告)号：US10143692B2
公开(公告)日：2018-12-04
申请号：US15861444
申请日：2018-01-03
Applicant: Array BioPharma Inc.
Inventor： Donald T. Corson , Christopher M. Lindemann , Daniel J. Watson
IPC: C07D471/04 , A61K31/437 , A61K31/517 , A61P35/00 , A61K45/06
Abstract: Polymorphs of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine are provided herein. Processes for preparing the polymorphs and pharmaceutical composition comprising the polymorphs are also disclosed.
-
公开(公告)号：US20180282324A1
公开(公告)日：2018-10-04
申请号：US15806650
申请日：2017-11-08
Applicant: Genentech, Inc. , Array Biopharma Inc.
Inventor： Jeffrey Stults , Christopher M. Lindemann , Keith L. Spencer , Weidong Liu , Joseph Lubach
IPC: C07D471/04 , A61K31/437 , A61K45/06
Abstract: Disclosed are crystalline forms of (R)—N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, and salts, solvates, and hydrates thereof, and pharmaceutical compositions, formulations and a process of manufacturing thereof.
-
公开(公告)号：US09457093B2
公开(公告)日：2016-10-04
申请号：US14351840
申请日：2012-10-12
Applicant: Array BioPharma Inc.
Inventor： David Shank Fry , Christopher M. Lindemann , Michael Preigh , Corey Jay Bloom , Christopher Donovan Craig , Devon Brevard Dubose , Jeff Gautschi , Dan Smithey
CPC classification number: A61K31/517 , A61K9/0053 , A61K9/10 , A61K9/1635 , A61K9/1652 , A61K9/2009 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K47/32 , A61K47/38
Abstract: A solid dispersion of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and processes for preparing the solid dispersion are provided herein. Also, a pharmaceutical composition comprising a solid dispersion of N4-(4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine and uses thereof are provided herein.
-
19.发明授权Polymorphs of ARRY-380, a selective HER 2 inhibitor and pharmaceutical compositions containing them 有权ARRY-380，选择性HER2抑制剂和含有它们的药物组合物的多晶型物公开(公告)号：US09168254B2
公开(公告)日：2015-10-27
申请号：US14351835
申请日：2012-10-12
Applicant: Array BioPharma Inc.
Inventor： Donald T. Corson , Christopher M. Lindemann , Daniel J. Watson
IPC: C07D471/04 , A61K31/437 , A61K31/517 , A61K45/06
CPC classification number: A61K31/517 , A61K31/437 , A61K45/06 , A61P35/00 , C07D471/04
Abstract: Polymorphs of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine are provided herein. Processes for preparing the polymorphs and pharmaceutical composition comprising the polymorphs are also disclosed.
Abstract translation: N 4 - （4 - （[1,2,4]三唑并[1,5-a]吡啶-7-基氧基）-3-甲基苯基）-N6-（4,4-二甲基-4,5-二氢恶唑-2-基） 吡啶-2-基）喹唑啉-4,6-二胺。 还公开了制备多晶型物的方法和包含多晶型物的药物组合物。
-
20.发明申请POLYMORPHS OF ARRY-380, A SELECTIVE HERB2 INHIBITOR AND PHARMACEUTICAL COMPOSITIONS CONTIANING THEM 有权ARRY-380的多聚体，选择性HERB2抑制剂和药物组合物公开(公告)号：US20140243361A1
公开(公告)日：2014-08-28
申请号：US14351835
申请日：2012-10-12
Applicant: Array BioPharma Inc.
Inventor： Donald T. Corson , Christopher M. Lindemann , Daniel J. Watson
IPC: A61K31/517 , A61K45/06 , C07D471/04
CPC classification number: A61K31/517 , A61K31/437 , A61K45/06 , A61P35/00 , C07D471/04
Abstract: Polymorphs of N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine are provided herein. Processes for preparing the polymorphs and pharmaceutical composition comprising the polymorphs are also disclosed.
Abstract translation: N 4 - （4 - （[1,2,4]三唑并[1,5-a]吡啶-7-基氧基）-3-甲基苯基）-N6-（4,4-二甲基-4,5-二氢恶唑-2-基） 吡啶-2-基）喹唑啉-4,6-二胺。 还公开了制备多晶型物的方法和包含多晶型物的药物组合物。
-
-
-
-
-
-
-
-
-
Search Results
20
records
(took 0.03 seconds)
