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公开(公告)号：US07432110B2
公开(公告)日：2008-10-07
申请号：US11659952
申请日：2005-08-04
IPC分类号： G01N1/18
CPC分类号： B01L3/502761 , B01F3/0807 , B01F5/0453 , B01F5/0456 , B01F13/0059 , B01L3/502707 , B01L2200/0668 , B01L2300/0816 , C12M23/16 , Y10T436/25375
摘要： A microchannel array according to the present invention includes a first substrate 1, and a second substrate 11 bonded to the first substrate 1. Two sets, that is, a set of a first through-hole 9, a first recess 7, and a first groove 8 and a set of a second through-hole 4, a second recess 2, and a second groove 3 are formed on the first substrate 1. The different sets are separated by a partition 5. A cell differentation/proliferation speed after micro-injection can be increased by using such microchannel array.
摘要翻译： 根据本发明的微通道阵列包括第一基板1和结合到第一基板1的第二基板11。 两组，即一组第一通孔9，第一凹槽7和第一凹槽8以及一组第二通孔4，第二凹槽2和第二凹槽3形成在 第一基板1。 不同的集合由分区5分隔。 通过使用这种微通道阵列可以增加微注射后的细胞分化/增殖速度。
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公开(公告)号：US20060121122A1
公开(公告)日：2006-06-08
申请号：US10525108
申请日：2003-09-17
申请人： Mitsutoshi Nakajima , Tatsuya Oda , Shinji Sugiura
发明人： Mitsutoshi Nakajima , Tatsuya Oda , Shinji Sugiura
CPC分类号： B01F3/0807 , A61K9/5036 , A61K9/5047 , A61K9/5089 , A61K48/00 , B01F5/0485 , B01F13/0059 , B01J13/06
摘要： A polyelectrolyte solution as a disperse phase is fed into one of the chambers which are partitioned by a plate having a plurality of narrow holes (microchannels), a continuous phase is fed into the other chamber, and pressure is applied to the disperse phase forcing it through the holes into the continuous phase so as to prepare an emulsion. This emulsion is demulsified, and at the same time the disperse phase is brought into contact with a polyelectrolyte solution having a reverse electric charge to the disperse phase or a polyvalent ion solution, and a gel layer is formed around the spherical disperse phase by a polyelectrolyte reaction. Thereby, a double-structured capsule is obtained, in which the outside is insoluble gel and the inside is a polyelectrolyte solution to which a cell has been added.
摘要翻译： 作为分散相的聚电解质溶液被供给到由具有多个窄孔（微通道）的板分隔的一个室中，将连续相进料到另一个室中，并且将压力施加到分散相上，迫使其 通过孔进入连续相，以制备乳液。 该乳液被破乳，同时使分散相与分散相或多价离子溶液具有反向电荷的聚电解质溶液接触，并且通过聚电解质在球形分散相周围形成凝胶层 反应。 由此，得到双层结构的胶囊，其中外部是不溶性凝胶，内部是已经添加了电池的聚电解质溶液。
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13.发明授权Cross-flow microchannel apparatus and method of producing or separating emulsions making use thereof 失效交叉流动微通道装置及其制造或分离乳液的方法公开(公告)号：US06258858B1
公开(公告)日：2001-07-10
申请号：US09260416
申请日：1999-03-01
IPC分类号： B01D1704
CPC分类号： B01F5/0401 , B01D17/041 , B01D17/044 , B01D17/10 , B01D61/18 , B01F3/0807 , B01F3/0865 , B01F5/0206 , B01F5/0475 , B01F13/0059 , B01F2003/0834 , B01F2005/0011 , Y10S366/03 , Y10S516/924 , Y10T137/0329 , Y10T137/87652
摘要： Cross-flow microchannel apparatus for producing emulsions includes a pump 9 and a pump 11 which are driven to respectively supply a continuous phase to a concave portion 4 via a supply pipe 10, a supply hole 6 and a supply port 18 and a dispersed phase to a space between the outside of a base 3 and the inside of a concave portion 2 formed in a case 1 via a supply pipe 12 and a supply hole 7. Then, by applying a predetermined pressure to the dispersed phase, the dispersed phase is formed into fine particles via a microchannels 21 and mixed with the continuous phase, thereby forming emulsions. The emulsions are withdrawn to a tank and so on via a withdrawal port 19, a withdrawal hole 8, and a withdrawal pipe 13 for emulsions. The apparatus can alternatively be used to separate an emulsion by pumping the emulsion within the concave portion 4 via pipe 10, hole 6 and port 18, such that the emulsion is separated via the microchannels 21 into a continuous phase that is withdrawn from the hole 7, and a dispersed phase that is withdrawn from the hole 8.
摘要翻译： 用于制造乳液的横流微通道装置包括泵9和泵11，其被驱动以经由供给管10，供应孔6和供给口18以及分散相分别向凹部4提供连续相， 经由供给管12和供给孔7形成在基体3的外部和形成在壳体1中的凹部2的内部之间的空间。然后，通过对分散相施加规定的压力，形成分散相 通过微通道21成为细颗粒并与连续相混合，从而形成乳液。 乳液经由抽出口19，抽出孔8和用于乳液的抽出管13而被抽出到罐等中。 该装置可以替代地用于通过管道10，孔6和端口18在凹部4内泵送乳液来分离乳液，使得乳液通过微通道21分离成从孔7中取出的连续相 ，以及从孔8中取出的分散相。
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公开(公告)号：US6155710A
公开(公告)日：2000-12-05
申请号：US125403
申请日：1998-08-18
CPC分类号： B01J13/00 , B01F13/0059 , B01F3/08 , B01F3/0807 , B01F3/0865 , B01F5/0206 , B01F5/0401 , B01F5/0475 , B01F2003/0834 , B01F2005/0011
摘要： A dispersed phase (O) supplied inside a bulkhead member (17) through a supply port (14) enters a gap (20) between a plate (16) and a base (18) through a supply port (19) of the base (18) and the dispersed phase (O) having entered the gap (20) then enters a continuous phase (W) through a boundary section (21) by virtue of pressure applied by a pressurizing means such as a pump. Then, the dispersed phase is made into a particle having a predetermined diameter by a microchannel (24) in passing through this boundary section (21), thereby forming an emulsion (E) in which the dispersed phase (O) of the predetermined diameter is dispersed in the continuous phase (W).
摘要翻译： PCT No.PCT / JP96 / 03492 Sec。 371日期1998年8月18日 102（e）1998年8月18日PCT PCT 1996年11月28日PCT公布。 公开号WO97 / 30783 日期1997年8月28日通过供给口（14）在隔板部件（17）内供给的分散相（O）通过供给口（19）进入板（16）和基部（18）之间的间隙（20） ）和已经进入间隙（20）的分散相（O）之后，通过借助诸如泵等加压装置施加的压力，通过边界部分（21）进入连续相（W）。 然后，分散相通过微通道（24）通过该边界部分（21）制成具有预定直径的颗粒，从而形成乳液（E），其中预定直径的分散相（O）为 分散在连续相（W）中。
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15.发明授权Process for producing microsphere with use of metal substrate having through-hole 有权使用具有通孔的金属基材制造微球的方法公开(公告)号：US07972543B2
公开(公告)日：2011-07-05
申请号：US11577474
申请日：2005-10-11
IPC分类号： B29B9/00
CPC分类号： B01J13/04 , A23P10/25 , A61K9/1682 , B01F3/0807 , B01F5/0475 , B01F13/0059 , B01F2215/0014 , B01F2215/0016 , B01F2215/0019 , B01F2215/0031 , B01F2215/0034 , B01J13/02 , C25D1/08 , Y10T428/24273
摘要： An object of the present invention is to provide a process for producing microspheres that are solid microparticles or liquid microparticles for use as an emulsion employed in the food industry, production of medicine and cosmetic etc. or an emulsion for DDS (drug delivery system). The object is attained by a process for producing a microsphere including: separating a disperse phase from a continuous phase by a substrate 1 having a through-hole 7; and extruding the disperse phase into the continuous phase through the through-hole 7, in which the substrate having the through-hole 7 with a width of 0.5 to 500 μm, a depth of 10 μm to 6000 μm and a ratio of the width to the depth of the through-hole 7 of 1 to 1/30 is a metal substrate.
摘要翻译： 本发明的目的是提供一种制备用作食品工业中使用的乳液的固体微粒或液体微粒的微球的制造方法，药物和化妆品的制造等，或用于DDS（药物输送系统）的乳液。 该目的通过一种制备微球体的方法来实现，包括：通过具有通孔7的基底1将分散相与连续相分离; 并且通过通孔7将分散相挤出到连续相中，其中具有宽度为0.5至500μm的通孔7的基底，深度为10μm至6000μm，宽度与 通孔7的深度为1〜1/30是金属基板。
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公开(公告)号：US20070276972A1
公开(公告)日：2007-11-29
申请号：US11659952
申请日：2005-08-04
IPC分类号： G06F13/00
CPC分类号： B01L3/502761 , B01F3/0807 , B01F5/0453 , B01F5/0456 , B01F13/0059 , B01L3/502707 , B01L2200/0668 , B01L2300/0816 , C12M23/16 , Y10T436/25375
摘要： A microchannel array according to the present invention includes a first substrate 1, and a second substrate 11 bonded to the first substrate 1. Two sets, that is, a set of a first through-hole 9, a first recess 7, and a first groove 8 and a set of a second through-hole 4, a second recess 2, and a second groove 3 are formed on the first substrate 1. The different sets are separated by a partition 5. A cell differentation/proliferation speed after micro-injection can be increased by using such microchannel array.
摘要翻译： 根据本发明的微通道阵列包括第一基板1和接合到第一基板1的第二基板11.两组，即一组第一通孔9，第一凹槽7和第一基板11。 凹槽8和一组第二通孔4，第二凹槽2和第二凹槽3形成在第一基底1上。不同的组由分隔体5分隔开。微孔之后的细胞分化/ 可以通过使用这种微通道阵列来增加注射。
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