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公开(公告)号:US20220332705A1
公开(公告)日:2022-10-20
申请号:US17004411
申请日:2020-08-27
Applicant: BIOGEN MA INC.
Inventor: Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , A61K31/506 , C07D239/30 , C07F5/02 , C07D401/14 , C07D413/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04 , C07D487/04
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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公开(公告)号:US10759783B2
公开(公告)日:2020-09-01
申请号:US16108755
申请日:2018-08-22
Applicant: BIOGEN MA INC.
Inventor: Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Lihong Sun , Lei Zhang , Gnanasambandam Kumaravel , Joseph P. Lyssikatos , Kevin Koch , Hua Miao
IPC: C07D403/12 , C07D417/14 , C07D495/04 , C07D409/14 , C07D401/14 , C07D513/04 , C07D413/14 , A61K31/506 , C07D239/30 , C07F5/02 , C07D417/12 , C07D487/04
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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公开(公告)号:US10280169B2
公开(公告)日:2019-05-07
申请号:US15103756
申请日:2014-12-11
Applicant: BIOGEN MA INC.
Inventor: Brian T. Hopkins , Bin Ma , Timothy Raymond Chan , Gnanasambandam Kumaravel , Hua Miao , Andrea Bertolotti-Ciarlet , Kevin Otipoby
IPC: C07D487/04 , C07D473/00 , A61K31/519 , A61K31/522 , C07D471/04 , C07D513/04 , C07D519/00 , G01N33/573
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
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公开(公告)号:US10189829B2
公开(公告)日:2019-01-29
申请号:US16113455
申请日:2018-08-27
Applicant: BIOGEN MA INC.
Inventor: Brian T. Hopkins , Bin Ma , Robin Prince , Isaac Marx , Joseph P. Lyssikatos , Fengmei Zheng , Matthew Peterson , Daniel B. Patience
IPC: C07D417/14 , C07D403/14 , C07D405/14 , C07D413/14 , A61P43/00
Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
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公开(公告)号:US20180291001A1
公开(公告)日:2018-10-11
申请号:US15875629
申请日:2018-01-19
Applicant: BIOGEN MA INC. , Sunesis Pharmaceuticals, Inc.
Inventor: Brian T. Hopkins , Xiongwei Cai , Timothy R. Chan , Patrick Conlon , Michael Humora , Tracy J. Jenkins , J. Michael Macphee , Xianglin Shi , Ross A. Miller , Andrew Thompson
IPC: C07D401/14 , C07D207/16 , C07D211/56 , C07D207/28 , C07D401/04
CPC classification number: C07D401/14 , C07B2200/13 , C07D207/16 , C07D207/28 , C07D211/56 , C07D401/04
Abstract: The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.
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公开(公告)号:US11858926B2
公开(公告)日:2024-01-02
申请号:US17871157
申请日:2022-07-22
Applicant: BIOGEN MA INC.
Inventor: Brian T. Hopkins , Bin Ma , Robin Prince , Isaac Marx , Joseph P. Lyssikatos , Fengmei Zheng , Matthew Peterson , Daniel B. Patience
IPC: C07D417/14 , C07D403/14 , C07D413/14 , C07D405/14 , C07D471/04 , A61P43/00 , A61P1/16
CPC classification number: C07D417/14 , A61P1/16 , A61P43/00 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/04 , C07B2200/13
Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
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公开(公告)号:US10961237B2
公开(公告)日:2021-03-30
申请号:US16534540
申请日:2019-08-07
Applicant: BIOGEN MA INC.
Inventor: Brian T. Hopkins , Bin Ma , Robin Prince , Isaac Marx , Joseph P. Lyssikatos , Fengmei Zheng , Matthew Peterson , Daniel B. Patience
IPC: C07D417/14 , C07D403/14 , C07D413/14 , C07D405/14 , C07D471/04 , A61P43/00 , A61P1/16
Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
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公开(公告)号:US10899753B2
公开(公告)日:2021-01-26
申请号:US16410725
申请日:2019-05-13
Applicant: BIOGEN MA INC.
Inventor: Brian T. Hopkins , Bin Ma , Robin Prince , Isaac Marx , Jürgen Schulz , Marta Nevalainen , Michael Dechantsreiter
IPC: C07D413/14 , C07D403/14 , C07D405/14
Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
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公开(公告)号:US09790229B2
公开(公告)日:2017-10-17
申请号:US15006061
申请日:2016-01-25
Applicant: Biogen MA Inc. , Sunesis Pharmaceuticals, Inc.
Inventor: Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC: C07D487/14 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04 , A61K31/519
CPC classification number: C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
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公开(公告)号:US20160376281A1
公开(公告)日:2016-12-29
申请号:US15006061
申请日:2016-01-25
Applicant: Biogen MA Inc. , Sunesis Pharmaceuticals, Inc.
Inventor: Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC: C07D487/14 , C07D413/14 , C07D417/14 , C07D401/14 , C07D401/04 , C07D473/34
CPC classification number: C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
Abstract translation: 本发明提供了可用作Btk抑制剂的化合物,其组合物及其使用方法。
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