公开(公告)号：US20180362652A1

公开(公告)日：2018-12-20

申请号：US15869514

申请日：2018-01-12

Applicant: Biogen MA Inc.

Inventor： Justin A. Caravella ,  Ellen A. Garber Stark ,  Dania Mounir Rabah ,  Frederick R. Taylor

IPC: C07K16/28 ,  A61K39/00

Abstract: Antibodies and antibody fragments that bind to BDCA2 are disclosed. Also disclosed are methods of using the antibodies and antibody fragments to induce death of a plasmacytoid dendritic cell, inhibit production or secretion of inflammatory cytokines and chemokines, and treat or prevent immunological disorders such as inflammatory and autoimmune conditions.

公开(公告)号：US20170369560A1

公开(公告)日：2017-12-28

申请号：US15427843

申请日：2017-02-08

Applicant: Biogen MA Inc. ,  Biogen International Neuroscience GmbH

Inventor： Paul H. Weinreb ,  Feng Chen ,  Ellen A. Garber Stark ,  Jan Grimm ,  Fabio Montrasio

IPC: C07K16/18 ,  A61K49/00 ,  A61K39/395 ,  G01N33/68 ,  A61K45/06 ,  A61K49/16 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K49/00 ,  A61K49/16 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/6896 ,  G01N2333/47 ,  G01N2800/2814

Abstract: Provided are novel human tau-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for tau are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for tau targeted immunotherapy and diagnosis, respectively.

公开(公告)号：US09644030B2

公开(公告)日：2017-05-09

申请号：US14597262

申请日：2015-01-15

Applicant: BIOGEN MA INC.

Inventor： Michael Karpusas ,  Paul D. Lyne ,  Ellen A. Garber Stark ,  Jose William Saldanha

IPC: A61K39/395 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2842 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  Y02A90/26

Abstract: Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.