公开(公告)号：US20180362652A1

公开(公告)日：2018-12-20

申请号：US15869514

申请日：2018-01-12

Applicant: Biogen MA Inc.

Inventor： Justin A. Caravella ,  Ellen A. Garber Stark ,  Dania Mounir Rabah ,  Frederick R. Taylor

IPC: C07K16/28 ,  A61K39/00

Abstract: Antibodies and antibody fragments that bind to BDCA2 are disclosed. Also disclosed are methods of using the antibodies and antibody fragments to induce death of a plasmacytoid dendritic cell, inhibit production or secretion of inflammatory cytokines and chemokines, and treat or prevent immunological disorders such as inflammatory and autoimmune conditions.

公开(公告)号：US09902775B2

公开(公告)日：2018-02-27

申请号：US14649297

申请日：2013-12-10

Applicant: Biogen MA Inc.

Inventor： Justin A. Caravella ,  Ellen A. Garber Stark ,  Dania Mounir Rabah ,  Frederick R. Taylor

IPC: A61K39/00 ,  C07K16/28

CPC classification number: C07K16/2851 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antibodies and antibody fragments that bind to BDCA2 are disclosed. Also disclosed are methods of using the antibodies and antibody fragments to induce death of a plasmacytoid dendritic cell, inhibit production or secretion of inflammatory cytokines and chemokines, and treat or prevent immunological disorders such as inflammatory and autoimmune conditions.