公开(公告)号：US10144732B2

公开(公告)日：2018-12-04

申请号：US15316534

申请日：2015-06-05

Applicant: BIOGEN MA INC.

Inventor： Gnanasambandam Kumaravel ,  Hairuo Peng ,  Zhili Xin

IPC: C07D471/04 ,  C07D487/04 ,  C07D519/00

Abstract: Compounds of formula (I) can modulate the activity of autotaxin (ATX).

公开(公告)号：US20170197960A1

公开(公告)日：2017-07-13

申请号：US15316534

申请日：2015-06-05

Applicant: BIOGEN MA INC.

Inventor： Gnanasambandam Kumaravel ,  Hairuo Peng ,  Zhili Xin

IPC: C07D471/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07D487/04 ,  C07D519/00

Abstract: Compounds of formula (I) can modulate the activity of autotaxin (ATX).

公开(公告)号：US09499485B2

公开(公告)日：2016-11-22

申请号：US14420025

申请日：2013-08-05

Applicant: BIOGEN MA INC.

Inventor： Kevin Guckian ,  Gnanasambandam Kumaravel ,  Bin Ma ,  Lihong Sun ,  Zhili Xin ,  Lei Zhang

IPC: C07D451/02 ,  C07D211/62 ,  A61K31/122 ,  A61K45/06 ,  A61K31/192 ,  A61K31/216 ,  A61K31/439 ,  A61K31/445 ,  A61K31/45 ,  C07C229/14 ,  C07C229/48 ,  C07D211/60 ,  A61K31/196 ,  A61K31/197 ,  A61K31/198 ,  A61K31/46 ,  C07D211/34 ,  C07D451/14

CPC classification number: C07D211/62 ,  A61K31/122 ,  A61K31/192 ,  A61K31/196 ,  A61K31/197 ,  A61K31/198 ,  A61K31/216 ,  A61K31/439 ,  A61K31/445 ,  A61K31/45 ,  A61K31/46 ,  A61K45/06 ,  C07C229/14 ,  C07C229/48 ,  C07C2601/14 ,  C07D211/34 ,  C07D211/60 ,  C07D451/02 ,  C07D451/14 ,  A61K2300/00

Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).

Abstract translation: 式（I）化合物可以调节一种或多种SIP受体的活性和/或自分泌素（ATX）的活性。

公开(公告)号：US20250152574A1

公开(公告)日：2025-05-15

申请号：US18837245

申请日：2023-02-13

Applicant: BIOGEN MA INC.

Inventor： Martin Himmelbauer ,  Felix Gonzalez Lopez de Turiso ,  John H. Jones ,  Edward Yin Shiang Lin ,  Robin Prince ,  Vatee Pattaropong ,  Zhili Xin ,  TeYu Chen ,  Nupur Bansal

IPC: A61K31/4709 ,  A61K31/438 ,  A61P25/28 ,  C07D221/20 ,  C07D401/12 ,  C07D491/107

Abstract: Provided are compounds of the Formula (I) or pharmaceutically acceptable salts thereof, which are useful for the inhibition of EBP and in the treatment of a variety of EBP mediated conditions or diseases, such as multiple sclerosis.

公开(公告)号：US11814362B2

公开(公告)日：2023-11-14

申请号：US17253269

申请日：2019-06-26

Applicant: BIOGEN MA INC.

Inventor： Felix Gonzalez Lopez de Turiso ,  Michael Dechantsreiter ,  Zhili Xin ,  John H. Jones ,  Martin Himmelbauer

IPC: C07D401/14

CPC classification number: C07D401/14

Abstract: Provided are compounds of Formula (I): including compounds of Formulas (II), (III) and (IV), wherein X, R1, R2, R3 and n are as defined herein, and pharmaceutically acceptable salts thereof, and methods for their use and production. These compounds can be useful, e.g., in the treatment of disorders responsive to the inhibition of apoptosis signal-regulating kinase 1 (ASK1).

公开(公告)号：US20230060003A1

公开(公告)日：2023-02-23

申请号：US17772646

申请日：2020-10-28

Applicant: BIOGEN MA INC.

Inventor： Nathan Genung ,  Kevin M. Guckian ,  Lei Zhang ,  Zhili Xin ,  Jeffrey Vessels ,  Ryan Gianatassio

IPC: C07D491/107 ,  C07D491/20 ,  C07D417/06

Abstract: Described herein are compounds represented by formula (I) or formula (Ia) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of preparing and using the same. The variables R1, R2, R3, R4, R5, R6, Y1, Y2, D, E, G1, G2, n and p are as defined herein.

公开(公告)号：US20220259197A1

公开(公告)日：2022-08-18

申请号：US17435125

申请日：2020-03-06

Applicant: BIOGEN MA INC.

Inventor： Nathan Genung ,  Kevin M. Guckian ,  Jeffrey Vessels ,  Lei Zhang ,  Ryan Gianatassio ,  Edward Yin Shiang Lin ,  Zhili Xin

IPC: C07D417/14 ,  C07D495/04

Abstract: Described herein are compounds represented by formula (I) (I) or a pharmaceutically acceptable salt thereof, pharmaceutical comositions comprising the same and methods of preparing and using the same. The variables Ar, X, R1, R3, R4, Y1, Y2, and Z are as defined herein.

公开(公告)号：US20210040080A1

公开(公告)日：2021-02-11

申请号：US16978550

申请日：2019-03-13

Applicant: BIOGEN MA INC.

Inventor： Nathan Genung ,  Kevin M. Guckian ,  Jeffrey Vessels ,  Lei Zhang ,  Ryan Gianatassio ,  Edward Yin Shiang Lin ,  Zhili Xin

IPC: C07D417/14 ,  C07D471/04 ,  C07D417/06

Abstract: Described herein are compounds represented by formula (I″) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of preparing and using the same. The variables Ar, Ra, Rb, m, n, Y1, Y2, R3 and R4 are defined herein.

公开(公告)号：US10017506B2

公开(公告)日：2018-07-10

申请号：US15296601

申请日：2016-10-18

Applicant: BIOGEN MA INC.

Inventor： Kevin M. Guckian ,  Gnanasambandam Kumaravel ,  Bin Ma ,  Sha Mi ,  Hairuo Peng ,  Zhaohui Shao ,  Lihong Sun ,  Arthur G. Taveras ,  Deping Wang ,  Zhili Xin ,  Lei Zhang

IPC: A61K31/015 ,  A61K31/4375 ,  A61K31/44 ,  C07D451/02 ,  C07D217/22 ,  A61K31/472 ,  A61K45/06 ,  A61K31/4725 ,  C07D401/06

CPC classification number: C07D451/02 ,  A61K31/136 ,  A61K31/196 ,  A61K31/439 ,  A61K31/445 ,  A61K31/46 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/5375 ,  A61K31/55 ,  A61K45/06 ,  C07B2200/07 ,  C07C217/22 ,  C07C229/46 ,  C07C229/48 ,  C07C255/59 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/42 ,  C07D209/52 ,  C07D211/34 ,  C07D211/62 ,  C07D217/22 ,  C07D221/22 ,  C07D223/06 ,  C07D295/096 ,  C07D401/06 ,  C07D471/08 ,  Y02A50/401

Abstract: Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.

公开(公告)号：US09550798B2

公开(公告)日：2017-01-24

申请号：US14417293

申请日：2013-07-26

Applicant: BIOGEN MA INC.

Inventor： Kevin Guckian ,  Gnanasambandam Kumaravel ,  Bin Ma ,  Sha Mi ,  Hairuo Peng ,  Zhaohui Shao ,  Lihong Sun ,  Arthur Taveras ,  Zhili Xin ,  Lei Zhang

IPC: C07C229/48 ,  C07D223/06 ,  C07D221/22 ,  C07D209/52 ,  C07D211/62 ,  C07D295/096 ,  A61K31/5375 ,  A61K31/439 ,  A61K31/46 ,  A61K31/445 ,  A61K31/196 ,  A61K31/136 ,  C07F7/08 ,  A61K45/06 ,  A61K31/195 ,  A61K31/41 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/5513 ,  C07D215/38 ,  C07D217/22 ,  C07D401/04 ,  C07D471/08 ,  C07C217/58 ,  C07C229/46 ,  C07C233/61 ,  C07C235/66 ,  A61K31/397 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61K31/551 ,  A61K31/695 ,  C07C211/38 ,  C07D205/04 ,  C07D213/74 ,  C07D215/20 ,  C07D401/06

CPC classification number: C07F7/081 ,  A61K31/195 ,  A61K31/196 ,  A61K31/397 ,  A61K31/403 ,  A61K31/41 ,  A61K31/439 ,  A61K31/451 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/495 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/551 ,  A61K31/5513 ,  A61K31/695 ,  A61K45/06 ,  C07C211/38 ,  C07C217/58 ,  C07C229/46 ,  C07C229/50 ,  C07C233/60 ,  C07C233/61 ,  C07C235/66 ,  C07C2102/10 ,  C07C2102/42 ,  C07C2102/44 ,  C07C2102/50 ,  C07C2103/62 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10 ,  C07C2602/42 ,  C07C2602/44 ,  C07C2602/46 ,  C07C2602/50 ,  C07C2603/62 ,  C07C2603/74 ,  C07D205/04 ,  C07D209/52 ,  C07D211/14 ,  C07D213/74 ,  C07D215/12 ,  C07D215/20 ,  C07D215/38 ,  C07D217/22 ,  C07D239/42 ,  C07D241/20 ,  C07D295/096 ,  C07D401/04 ,  C07D401/06 ,  C07D451/02 ,  C07D451/14 ,  C07D471/08 ,  C07D491/107 ,  C07F7/0805 ,  A61K2300/00

Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).

Abstract translation: 式（I）化合物可以调节一种或多种SIP受体的活性和/或自分泌素（ATX）的活性。