公开(公告)号：US20240000800A1

公开(公告)日：2024-01-04

申请号：US18172024

申请日：2023-02-21

Applicant: Board of Regents of the University of Nebraska

Inventor： Dong Wang ,  Fang Yuan ,  Zhenshan Jia ,  Xiaobei Wang

IPC: A61K31/57 ,  C07J41/00 ,  A61K9/107 ,  A61K47/10 ,  A61K47/34

CPC classification number: A61K31/57 ,  C07J41/0016 ,  C07J41/0005 ,  A61K9/1075 ,  A61K47/10 ,  A61K47/34 ,  C07J51/00

Abstract: Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for treating inflammatory and autoimmune diseases, including but not limited to lupus, are disclosed.

公开(公告)号：US20220008543A1

公开(公告)日：2022-01-13

申请号：US17288814

申请日：2019-10-27

Applicant: Board of Regents of the University of Nebraska

Inventor： Dong Wang ,  Steven R. Goldring ,  Gang Zhao ,  Rongguo Ren ,  Zhenshan Jia ,  Xin Wei

IPC: A61K47/58 ,  A61K47/69 ,  A61K47/54 ,  A61K47/55

Abstract: This application discloses prodrug-based thermosensitive gel (“ProGel”) comprised of conjugates of dmg molecules with water-soluble polymeric carriers, which are capable of controlled release of the dmg molecules into the tissue of a subject. Use of the ProGel-Drug conjugates for treatment of various diseases or disorders and methods of preparing them are also disclosed.

公开(公告)号：US20210100909A1

公开(公告)日：2021-04-08

申请号：US17065188

申请日：2020-10-07

Applicant: United States Government As Represented By The Department of Veterans Affairs ,  Board Of Regents Of The University Of Nebraska

Inventor： Weiping Qin ,  William A. Bauman ,  Dong Wang

IPC: A61K47/58 ,  A61K45/06 ,  A61P25/00 ,  A61P29/00

Abstract: Disclosed herein are polymeric methylprednisolone conjugates and prodrugs as well as method of using the same. Disclosed herein are methods of treating a spinal cord injury in a subject comprising: systemically delivering a composition comprising a polymeric methylprednisolone conjugate to the subject. Disclosed herein are methods of enhancing neuroprotection in a subject after spinal cord injury comprising systemically delivering a composition comprising a polymeric methylprednisolone conjugate to the subject.

公开(公告)号：US10933071B2

公开(公告)日：2021-03-02

申请号：US16694722

申请日：2019-11-25

Applicant: Board of Regents of the University of Nebraska

Inventor： Dong Wang ,  Fang Yuan ,  Zhenshan Jia ,  Xiaobei Wang

IPC: A61K31/57 ,  C07J41/00 ,  A61K9/107 ,  A61K47/10 ,  A61K47/34 ,  C07J51/00

Abstract: Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for treating inflammatory and autoimmune diseases, including but not limited to lupus, are disclosed.