公开(公告)号：US20160176864A1

公开(公告)日：2016-06-23

申请号：US14580355

申请日：2014-12-23

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Derek J. Norris ,  George V. Delucca ,  Ashvinikumar V. Gavai ,  Claude A. Quesnelle ,  Patrice Gill ,  Daniel O'Malley ,  Wayne Vaccaro ,  Francis Y. Lee ,  Mikkel V. DeBenedetto ,  Andrew P. Degnan ,  Haiquan Fang ,  Matthew D. Hill ,  Hong Huang ,  William D. Schmitz ,  John E. Starrett, JR. ,  Wen-Ching Han ,  John S. Tokarski ,  Sunil Kumar Mandal

IPC: C07D471/04 ,  A61K31/437

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

公开(公告)号：US20170305929A1

公开(公告)日：2017-10-26

申请号：US15523416

申请日：2015-11-03

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James H. Cook, II ,  F. Christopher Zusi ,  Matthew D. Hill

IPC: C07D498/22

CPC classification number: C07D498/22 ,  C07D498/10

Abstract: There are disclosed a series of quinuclidines having the Formula (I), which bind to the nicotinic α7 receptor and may be useful for the treatment of disorders of the central nervous system.

公开(公告)号：US20160318928A1

公开(公告)日：2016-11-03

申请号：US15107652

申请日：2014-12-23

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Derek J. Norris ,  George V. Delucca ,  Ashvinikumar V. Gavai ,  Claude A. Quesnelle ,  Patrice Gill ,  Daniel O'Malley ,  Wayne Vaccaro ,  Francis Y. Lee ,  Mikkel V. DeBenedetto ,  Andrew P. Degnan ,  Haiquan Fang ,  Matthew D. Hill ,  Hong Huang ,  William D. Schmitz ,  John E. Starrett, JR. ,  Wen-Ching Han ,  John S. Tokarski ,  Sunil Kumar Mandal

IPC: C07D471/04 ,  A61K31/501 ,  A61K31/506 ,  A61K31/437 ,  A61K31/444

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/444 ,  A61K31/501 ,  A61K31/506

Abstract: The present invention is directed to tricyclic compounds (I), pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

公开(公告)号：US09688669B2

公开(公告)日：2017-06-27

申请号：US15026759

申请日：2014-10-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Andrew P. Degnan ,  Darrell Maxwell ,  Matthew D. Hill ,  Haiquan Fang ,  Michael F. Parker ,  Fukang Yang ,  Joanne J. Bronson ,  John E. Macor

IPC: C07D413/14 ,  C07D413/04 ,  C07D263/24

CPC classification number: C07D413/04 ,  C07B2200/07 ,  C07D263/24 ,  C07D413/14

Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, agonists and partial agonists for the mGluR5 receptor and may be useful for the treatment of various disorders of the central nervous system.

公开(公告)号：US20160237072A1

公开(公告)日：2016-08-18

申请号：US15026759

申请日：2014-10-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Andrew P. Degnan ,  Darrell Maxwell ,  Matthew D. Hill ,  Haiquan Fang ,  Michael F. Parker ,  Fukang Yang ,  Joanne J. Bronson ,  John E. Macor

IPC: C07D413/04 ,  C07D263/24 ,  C07D413/14

CPC classification number: C07D413/04 ,  C07B2200/07 ,  C07D263/24 ,  C07D413/14

Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, agonists and partial agonists for the mGluR5 receptor and may be useful for the treatment of various disorders of the central nervous system.

Abstract translation: 本公开内容通常涉及式I化合物，包括其盐，以及使用该化合物的组合物和方法。 这些化合物是mGluR5受体的配体，激动剂和部分激动剂，并且可用于治疗中枢神经系统的各种疾病。