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公开(公告)号：US10174052B2
公开(公告)日：2019-01-08
申请号：US15523416
申请日：2015-11-03
IPC分类号： C07D498/22 , A61K31/439 , C07D498/10
摘要： There are disclosed a series of quinuclidines having the Formula (I), which bind to the nicotinic α7 receptor and may be useful for the treatment of disorders of the central nervous system.
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公开(公告)号：US20160101104A1
公开(公告)日：2016-04-14
申请号：US14974248
申请日：2015-12-18
发明人： James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. lwuagwu , F. Christopher Zusi , John E. Macor
IPC分类号： A61K31/506
CPC分类号： A61K31/506 , A61K31/439 , C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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3.发明申请QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 审中-公开喹啉化合物作为ALPHA-7非丁醇乙酰胆碱受体配体公开(公告)号：US20150094309A1
公开(公告)日：2015-04-02
申请号：US14574653
申请日：2014-12-18
发明人： James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor
IPC分类号： C07D519/00
CPC分类号： A61K31/506 , A61K31/439 , C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
摘要翻译： 本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。 这些化合物是烟碱型α7受体的配体，可用于治疗中枢神经系统的各种疾病，特别是情感和神经退行性疾病。
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公开(公告)号：US20170305929A1
公开(公告)日：2017-10-26
申请号：US15523416
申请日：2015-11-03
IPC分类号： C07D498/22
CPC分类号： C07D498/22 , C07D498/10
摘要： There are disclosed a series of quinuclidines having the Formula (I), which bind to the nicotinic α7 receptor and may be useful for the treatment of disorders of the central nervous system.
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公开(公告)号：US20150342935A1
公开(公告)日：2015-12-03
申请号：US14820412
申请日：2015-08-06
发明人： James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor
IPC分类号： A61K31/439
CPC分类号： A61K31/506 , A61K31/439 , C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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6.发明申请Quinuclidine Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands 审中-公开奎宁环化合物作为α-7烟碱乙酰胆碱受体配体公开(公告)号：US20140221377A1
公开(公告)日：2014-08-07
申请号：US14246566
申请日：2014-04-07
发明人： James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor
IPC分类号： C07D498/20
CPC分类号： A61K31/506 , A61K31/439 , C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
摘要翻译： 本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。 这些化合物是烟碱型α7受体的配体，可用于治疗中枢神经系统的各种疾病，特别是情感和神经变性疾病。
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7.发明申请Quinuclidine Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligands 审中-公开奎宁环化合物作为α-7烟碱乙酰胆碱受体配体公开(公告)号：US20130131064A1
公开(公告)日：2013-05-23
申请号：US13740390
申请日：2013-01-14
发明人： James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor
IPC分类号： C07D498/20
CPC分类号： A61K31/506 , A61K31/439 , C07D498/20 , C07D519/00
摘要： The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
摘要翻译： 本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。 这些化合物是烟碱型α7受体的配体，可用于治疗中枢神经系统的各种疾病，特别是情感和神经退行性疾病。
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