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11.METHODS OF USING AS ANALGESICS 1-BENZYL-1-HYDROXY-2, 3-DIAMINO-PROPYL AMINES, 3-BENZYL-3-HYRDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS 有权
标题翻译: 使用1-苄基-1-羟基-2,3-二氨基丙酸,3-苄基-3-羟基-2-氨基 - 丙酸和其相关化合物的方法公开(公告)号:US20120225881A1
公开(公告)日:2012-09-06
申请号:US13450854
申请日:2012-04-19
申请人: Bertrand Leblond , Eric Beausoleil , Thierry Taverne , John E. Donello , Fabien (Jacques) Schweighoffer
发明人: Bertrand Leblond , Eric Beausoleil , Thierry Taverne , John E. Donello , Fabien (Jacques) Schweighoffer
IPC分类号: A61K31/40 , A61K31/5375 , A61P25/00 , A61K31/4025
CPC分类号: C07D265/30 , A61K31/40 , A61K31/4025 , A61K31/4409 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/541 , C07D207/09 , C07D213/64 , C07D295/12 , C07D295/13 , C07D295/15 , C07D319/18 , C07D405/06
摘要: The compounds shown by the structural formulas below have analgesic effect and are used in compositions and methods for treating mammal in need of such treatment.
摘要翻译: 由下述结构式表示的化合物具有镇痛作用,并用于治疗需要这种治疗的哺乳动物的组合物和方法中。
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12.3-(4-fluorophenyl)-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic activity 有权
标题翻译: 3-(4-氟苯基)-3-羟基-2-氨基 - 丙酰胺和具有止痛活性的相关化合物公开(公告)号:US08168631B2
公开(公告)日:2012-05-01
申请号:US12364930
申请日:2009-02-03
申请人: Bertrand Leblond , Eric Beausoleil , Thierry Taverne , John E. Donello , Rong Yang , Cédric Chauvignac
发明人: Bertrand Leblond , Eric Beausoleil , Thierry Taverne , John E. Donello , Rong Yang , Cédric Chauvignac
IPC分类号: A61K31/40 , A61K31/426 , A61K31/4453 , A61K31/5375 , A61K31/165
CPC分类号: C07D277/04 , C07C229/36 , C07C233/11 , C07C259/06 , C07C271/22 , C07C311/06 , C07D207/10 , C07D207/20 , C07D295/185
摘要: Compounds according to the formula below are disclosed herein: Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译: 本文公开了根据下式的化合物:还公开了与之相关的治疗方法,组合物和药物。
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13.3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic and/or immuno stimulant activity 有权
标题翻译: 3-芳基-3-羟基-2-氨基 - 丙酸酰胺,3-杂芳基-3-羟基-2-氨基 - 丙酰胺和具有止痛和/或免疫刺激活性的相关化合物公开(公告)号:US08431599B2
公开(公告)日:2013-04-30
申请号:US13612260
申请日:2012-09-12
IPC分类号: A61K31/4439 , A61K31/47
CPC分类号: C07D265/30 , A61K31/40 , A61K31/4025 , A61K31/4409 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/541 , C07D207/09 , C07D213/64 , C07D295/12 , C07D295/13 , C07D295/15 , C07D319/18 , C07D405/06
摘要: Compounds of Formulas 1 and 2 where the variables have the meaning disclosed in the specification, have analgesic and in some cases immunostimulant activity.
摘要翻译: 式1和2的化合物,其中变量具有说明书中公开的含义,具有镇痛作用,在某些情况下具有免疫刺激活性。
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14.SUBSTITUTED 6,7-DIALKOXY-3-ISOQUINOLINOL DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE 10 (PDE10A) 有权
标题翻译: 取代作为磷酸二酯酶10(PDE10A)的抑制剂的6,7-二氧代-3-异喹啉衍生物公开(公告)号:US20120214837A1
公开(公告)日:2012-08-23
申请号:US13399351
申请日:2012-02-17
申请人: Bertrand Leblond , Cédric Chauvignac , Thierry Taverne , Eric Beausoleil , Anne-Sophie Casagrande , Laurent Désiré , Matthew P. Pando , John E. Donello , Rong Yang
发明人: Bertrand Leblond , Cédric Chauvignac , Thierry Taverne , Eric Beausoleil , Anne-Sophie Casagrande , Laurent Désiré , Matthew P. Pando , John E. Donello , Rong Yang
IPC分类号: A61K31/472 , A61K31/4725 , C07D401/06 , C07D405/10 , C07D401/14 , C07D491/056 , A61K31/4741 , A61P25/00 , A61P25/22 , A61P25/18 , A61P25/28 , A61P25/16 , A61P25/14 , A61P25/24 , A61P3/10 , A61P27/02 , A61P35/00 , A61P29/00 , C07D217/24
CPC分类号: C07D401/14 , C07D217/24 , C07D401/06 , C07D405/06 , C07D491/056
摘要: The invention relates to compounds of the formula wherein R′, R1, through R7 and Ar are as defined herein. These compounds are useful as inhibitors of phosphodiesterase 10 (PDE10A) which are useful in treating central nervous system diseases such as psychosis and also in treating, for example, obesity, type II diabetes, metabolic syndrome, glucose intolerance, pain and ophthalmic diseases.
摘要翻译: 本发明涉及下式的化合物其中R 1,R 1,R 7和Ar如本文所定义。 这些化合物可用作磷酸二酯酶10(PDE10A)的抑制剂,其可用于治疗中枢神经系统疾病如精神病以及治疗例如肥胖,II型糖尿病,代谢综合征,葡萄糖不耐受,疼痛和眼科疾病。
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15.3-heteroaryl-3-hydroxy-2-amino-propyl amines and related compounds having analgesic and/or immuno stimlant activity 有权
标题翻译: 1-芳基-1-羟基-2,3-二氨基丙基胺,1-杂芳基-1-羟基-2,3-二氨基丙基胺和具有止痛和/或免疫刺激活性的相关化合物公开(公告)号:US08013000B2
公开(公告)日:2011-09-06
申请号:US11814601
申请日:2006-01-25
IPC分类号: A61K31/44 , C07D401/06
CPC分类号: C07D265/30 , A61K31/40 , A61K31/4025 , A61K31/4409 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/541 , C07D207/09 , C07D213/64 , C07D295/12 , C07D295/13 , C07D295/15 , C07D319/18 , C07D405/06
摘要: Compounds of the formula where the variables have the meaning defined in the specification have analgesic and/or immunostimulant effect in mammals.
摘要翻译: 变量具有本说明书中定义的含义的式的化合物在哺乳动物中具有止痛和/或免疫刺激作用。
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16.3-(4-FLUOROPHENYL)-3-HYDROXY-2-AMINO-PROPIONIC ACID AMIDES AND RELATED COMPOUNDS HAVING ANALGESIC ACTIVITY 有权
标题翻译: 3-(4-氟苯基)-3-羟基-2-氨基 - 丙酸和相关化合物具有活性公开(公告)号:US20090281085A1
公开(公告)日:2009-11-12
申请号:US12364930
申请日:2009-02-03
申请人: Bertrand Leblond , Eric Beausoleil , Thierry Taverne , John E. Donello , Rong Yang , Cédric Chauvignac
发明人: Bertrand Leblond , Eric Beausoleil , Thierry Taverne , John E. Donello , Rong Yang , Cédric Chauvignac
IPC分类号: A61K31/55 , C07D207/04 , A61K31/40 , C07D265/30 , A61K31/5375 , C07D211/60 , A61K31/445 , C07C237/02 , A61K31/165 , C07D223/04 , A61P29/00
CPC分类号: C07D277/04 , C07C229/36 , C07C233/11 , C07C259/06 , C07C271/22 , C07C311/06 , C07D207/10 , C07D207/20 , C07D295/185
摘要: Compounds according to the formula below are disclosed herein: Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译: 本文公开了根据下式的化合物:还公开了与之相关的治疗方法,组合物和药物。
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17.Methods of using as analgesics 1-benzyl-1-hydroxy-2, 3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds 有权
标题翻译: 用作止痛剂的方法1-苄基-1-羟基-2,3-二氨基丙基胺,3-苄基-3-羟基-2-氨基 - 丙酸酰胺和相关化合物公开(公告)号:US09278943B2
公开(公告)日:2016-03-08
申请号:US13450854
申请日:2012-04-19
申请人: Bertrand Leblond , Eric Beausoleil , Thierry Taverne , John E. Donello , Fabien (Jacques) Schweighoffer
发明人: Bertrand Leblond , Eric Beausoleil , Thierry Taverne , John E. Donello , Fabien (Jacques) Schweighoffer
IPC分类号: A61K31/535 , A61K31/40 , C07D265/30 , A61K31/4025 , A61K31/5375 , C07D213/64 , C07D295/12 , C07D319/18 , A61K31/4409 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/541
CPC分类号: C07D265/30 , A61K31/40 , A61K31/4025 , A61K31/4409 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/541 , C07D207/09 , C07D213/64 , C07D295/12 , C07D295/13 , C07D295/15 , C07D319/18 , C07D405/06
摘要: The compounds shown by the structural formulas below have analgesic effect and are used in compositions and methods for treating mammal in need of such treatment.
摘要翻译: 由下述结构式表示的化合物具有镇痛作用,并用于治疗需要这种治疗的哺乳动物的组合物和方法中。
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公开(公告)号:US08835463B2
公开(公告)日:2014-09-16
申请号:US13409853
申请日:2012-03-01
IPC分类号: A61K31/4409 , C07D401/06 , A61K31/4025 , C07D319/18 , A61K31/4709 , A61K31/5377 , C07D213/64 , A61K31/4439 , C07D265/30 , C07D295/12 , A61K31/5375 , A61K31/541 , A61K31/4545 , A61K31/496 , A61K31/40
CPC分类号: C07D265/30 , A61K31/40 , A61K31/4025 , A61K31/4409 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/541 , C07D207/09 , C07D213/64 , C07D295/12 , C07D295/13 , C07D295/15 , C07D319/18 , C07D405/06
摘要: The compounds shown by their structural formulas in the specification have analgesic and or immunostimulant activity in mammals.
摘要翻译: 在本说明书中通过其结构式表示的化合物在哺乳动物中具有止痛和/或免疫刺激活性。
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公开(公告)号:US20130005717A1
公开(公告)日:2013-01-03
申请号:US13612260
申请日:2012-09-12
IPC分类号: A61K31/4439 , A61P25/00 , A61K31/541 , A61K31/4709 , A61K31/5377
CPC分类号: C07D265/30 , A61K31/40 , A61K31/4025 , A61K31/4409 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/541 , C07D207/09 , C07D213/64 , C07D295/12 , C07D295/13 , C07D295/15 , C07D319/18 , C07D405/06
摘要: Compounds of Formulas 1 and 2 where the variables have the meaning disclosed in the specification, have analgesic and in some cases immunostimulant activity.
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20.3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic and/or immuno stimulant activity 有权
标题翻译: 3-芳基-3-羟基-2-氨基 - 丙酸酰胺,3-杂芳基-3-羟基-2-氨基 - 丙酰胺和具有止痛和/或免疫刺激活性的相关化合物公开(公告)号:US08288556B2
公开(公告)日:2012-10-16
申请号:US11814598
申请日:2006-01-25
IPC分类号: C07D413/06 , C07D401/06 , C07D215/38 , C07D213/04 , A61K31/5377 , A61K31/4709 , A61K31/4402 , A61K31/4458
CPC分类号: C07D265/30 , A61K31/40 , A61K31/4025 , A61K31/4409 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/541 , C07D207/09 , C07D213/64 , C07D295/12 , C07D295/13 , C07D295/15 , C07D319/18 , C07D405/06
摘要: Compounds of Formulas 1 and 2 where the variables have the meaning disclosed in the specification, have analgesic and in some cases immunostimulant activity.
摘要翻译: 式1和2的化合物,其中变量具有说明书中公开的含义,具有镇痛作用,在某些情况下具有免疫刺激活性。
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