公开(公告)号：US20210017504A1

公开(公告)日：2021-01-21

申请号：US16928915

申请日：2020-07-14

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Arkadiusz Bibillo ,  Pranav Patel

IPC: C12N9/12 ,  C12R1/01

Abstract: Hybrid reverse transcriptases are provided that comprise a non-retroviral retrotransposon, or a fragment of the non-retroviral retrotransposon having reverse transcriptase activity, joined to a nucleic acid binding protein. Also provided are methods of using the hybrid reverse transcriptases to prepare a cDNA molecule library.

公开(公告)号：US12163164B2

公开(公告)日：2024-12-10

申请号：US16928915

申请日：2020-07-14

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Arkadiusz Bibillo ,  Pranav Patel

IPC: C12N9/12 ,  C12N1/20 ,  C12R1/01 ,  C40B40/06

Abstract: Hybrid reverse transcriptases are provided that comprise a non-retroviral retrotransposon, or a fragment of the non-retroviral retrotransposon having reverse transcriptase activity, joined to a nucleic acid binding protein. Also provided are methods of using the hybrid reverse transcriptases to prepare a cDNA molecule library.

公开(公告)号：US20240026316A1

公开(公告)日：2024-01-25

申请号：US18348544

申请日：2023-07-07

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Arkadiusz Bibillo ,  Pranav Patel

IPC: C12N9/12

CPC classification number: C12N9/1276 ,  C12Y207/07049 ,  C07K2319/20

Abstract: The present disclosure provides methods and systems for amplifying and analyzing nucleic acid samples. The present disclosure provides methods for preparing cDNA and/or DNA molecules and cDNA and/or DNA libraries using modified reverse transcriptases.

公开(公告)号：US10954557B2

公开(公告)日：2021-03-23

申请号：US16168002

申请日：2018-10-23

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Arkadiusz Bibillo ,  Pranav Patel

IPC: C12Q1/686 ,  C12N9/12 ,  C12Q1/6844 ,  C12N15/10 ,  C12Q1/68 ,  C12P19/34 ,  C12Q1/6806

Abstract: The present disclosure provides methods and systems for amplifying and analyzing nucleic acid samples. The present disclosure provides methods for preparing cDNA and/or DNA molecules and cDNA and/or DNA libraries using modified reverse transcriptases.