公开(公告)号：US20160256553A1

公开(公告)日：2016-09-08

申请号：US14660488

申请日：2015-03-17

申请人： BioMarin Pharmaceutical Inc.

发明人： Daniel J. Wendt ,  Shinong Long ,  Sianna Castillo ,  Christopher P. Price ,  Mika Aoyagi-Scharber ,  Michel Claude Vellard ,  Augustus O. Okhamafe

IPC分类号： A61K47/26 ,  A61K47/10 ,  A61K9/08 ,  A61K47/22 ,  A61K38/22 ,  A61K47/20

CPC分类号： C07K14/58 ,  A61K9/08 ,  A61K38/00 ,  A61K38/22 ,  A61K38/2242 ,  A61K47/10 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61K47/60 ,  G01N2333/58 ,  G01N2800/10 ,  G01N2800/105 ,  G01N2800/385 ,  G01N2800/52

摘要： The present disclosure provides variants of C-type natriuretic peptide (CNP), pharmaceutical compositions comprising CNP variants, and methods of making CNP variants. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders, such as skeletal dysplasias (e.g., achondroplasia), and vascular smooth muscle disorders (e.g., restenosis and arteriosclerosis).

摘要翻译： 本公开提供了C型利钠肽（CNP），包含CNP变体的药物组合物和制备CNP变体的方法的变体。 CNP变体可用作治疗针对CNP的疾病的治疗剂，包括但不限于骨相关疾病，例如骨骼发育不良（例如软骨发育不良）和血管平滑肌病（例如再狭窄和动脉硬化）。

公开(公告)号：US20240156914A1

公开(公告)日：2024-05-16

申请号：US18425954

申请日：2024-01-29

申请人： BIOMARIN PHARMACEUTICAL INC.

发明人： Sherry Bullens ,  Stuart Bunting ,  Tianwei Chou ,  Augustus O. Okhamafe ,  Christopher P. Price ,  Daniel J. Wendt ,  Clarence Yap

IPC分类号： A61K38/22 ,  A61K9/00 ,  A61K9/19 ,  A61K38/17 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/20 ,  A61K47/26

CPC分类号： A61K38/2242 ,  A61K9/0019 ,  A61K9/19 ,  A61K38/1709 ,  A61K47/10 ,  A61K47/12 ,  A61K47/183 ,  A61K47/20 ,  A61K47/26

摘要： The present disclosure provides for use of variants of C-type natriuretic peptide (CNP), and novel pharmaceutical compositions and formulations comprising CNP variant peptides for the treatment of skeletal dysplasias, one or more symptoms of skeletal dysplasias, such as long bone growth or growth velocity, and other disorders having a skeletal dysplasia and/or CNP-associated symptom or component.

公开(公告)号：US10646550B2

公开(公告)日：2020-05-12

申请号：US15880002

申请日：2018-01-25

申请人： BIOMARIN PHARMACEUTICAL INC.

发明人： Sherry Bullens ,  Stuart Bunting ,  Tianwei Chou ,  Augustus O. Okhamafe ,  Christopher P. Price ,  Daniel J. Wendt ,  Clarence Yap

IPC分类号： A61K38/22 ,  A61K38/00 ,  A61K38/16 ,  A61K9/19 ,  A61K47/12 ,  A61K47/26 ,  A61K47/18 ,  A61K47/10 ,  A61K9/00 ,  A61K38/17

摘要： The present disclosure provides for use of variants of C-type natriuretic peptide (CNP), and novel pharmaceutical compositions and formulations comprising CNP variant peptides for the treatment of skeletal dysplasias, one or more symptoms of skeletal dysplasias, such as long bone growth or growth velocity, and other disorders having a skeletal dysplasia and/or CNP-associated symptom or component.