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公开(公告)号：US11911446B2
公开(公告)日：2024-02-27
申请号：US16837905
申请日：2020-04-01
发明人： Sherry Bullens , Stuart Bunting , Tianwei Chou , Augustus O. Okhamafe , Christopher P. Price , Daniel J. Wendt , Clarence Yap
IPC分类号： A61K38/22 , A61K38/17 , A61K9/19 , A61K47/12 , A61K47/26 , A61K47/10 , A61K9/00 , A61K47/20 , A61K47/18
CPC分类号： A61K38/2242 , A61K9/0019 , A61K9/19 , A61K38/1709 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/20 , A61K47/26
摘要： The present disclosure provides for use of variants of C-type natriuretic peptide (CNP), and novel pharmaceutical compositions and formulations comprising CNP variant peptides for the treatment of skeletal dysplasias, one or more symptoms of skeletal dysplasias, such as long bone growth or growth velocity, and other disorders having a skeletal dysplasia and/or CNP-associated symptom or component.
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公开(公告)号：USRE46707E1
公开(公告)日：2018-02-13
申请号：US14604262
申请日：2015-01-23
发明人： Daniel J. Wendt , Shinong Long , Sianna Castillo , Christopher P. Price , Mika Aoyagi-Scharber , Michel Claude Vellard , Augustus O. Okhamafe
CPC分类号： C07K14/58 , A61K9/08 , A61K38/00 , A61K38/22 , A61K38/2242 , A61K47/10 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/60 , G01N2333/58 , G01N2800/10 , G01N2800/105 , G01N2800/385 , G01N2800/52
摘要： The present disclosure provides variants of C-type natriuretic peptide (CNP), pharmaceutical compositions comprising CNP variants, and methods of making CNP variants. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders, such as skeletal dysplasias (e.g., achondroplasia), and vascular smooth muscle disorders (e.g., restenosis and arteriosclerosis).
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公开(公告)号：US20170051033A1
公开(公告)日：2017-02-23
申请号：US15332793
申请日：2016-10-24
发明人： Daniel J. Wendt , Shinong Long , Sianna Castillo , Christopher P. Price , Mika Aoyagi-Scharber , Michel Claude Vellard , Augustus O. Okhamafe
CPC分类号： C07K14/58 , A61K9/08 , A61K38/00 , A61K38/22 , A61K38/2242 , A61K47/10 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/60 , G01N2333/58 , G01N2800/10 , G01N2800/105 , G01N2800/385 , G01N2800/52
摘要： The present disclosure provides variants of C-type natriuretic peptide (CNP), pharmaceutical compositions comprising CNP variants, and methods of making CNP variants. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders, such as skeletal dysplasias (e.g., achondroplasia), and vascular smooth muscle disorders (e.g., restenosis and arteriosclerosis).
摘要翻译： 本公开提供了C型利钠肽（CNP），包含CNP变体的药物组合物和制备CNP变体的方法的变体。 CNP变体可用作治疗针对CNP的疾病的治疗剂，包括但不限于骨相关疾病，例如骨骼发育不良（例如软骨发育不良）和血管平滑肌病（例如再狭窄和动脉硬化）。
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公开(公告)号：US11590204B2
公开(公告)日：2023-02-28
申请号：US16837910
申请日：2020-04-01
发明人： Sherry Bullens , Stuart Bunting , Tianwei Chou , Augustus O. Okhamafe , Christopher P. Price , Daniel J. Wendt , Clarence Yap
IPC分类号： A61K38/22 , A61K38/00 , A61K38/16 , A61K9/19 , A61K47/12 , A61K47/26 , A61K47/10 , A61K9/00 , A61K38/17 , A61K47/20 , A61K47/18
摘要： The present disclosure provides for use of variants of C-type natriuretic peptide (CNP), and novel pharmaceutical compositions and formulations comprising CNP variant peptides for the treatment of skeletal dysplasias, one or more symptoms of skeletal dysplasias, such as long bone growth or growth velocity, and other disorders having a skeletal dysplasia and/or CNP-associated symptom or component.
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公开(公告)号：US20200246434A1
公开(公告)日：2020-08-06
申请号：US16837910
申请日：2020-04-01
发明人： Sherry Bullens , Stuart Bunting , Tianwei Chou , Augustus O Okhamafe , Christopher P. Price , Daniel J. Wendt , Clarence Yap
摘要： The present disclosure provides for use of variants of C-type natriuretic peptide (CNP), and novel pharmaceutical compositions and formulations comprising CNP variant peptides for the treatment of skeletal dysplasias, one or more symptoms of skeletal dysplasias, such as long bone growth or growth velocity, and other disorders having a skeletal dysplasia and/or CNP-associated symptom or component.
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6.发明申请公开(公告)号：US20170028023A1
公开(公告)日：2017-02-02
申请号：US15225355
申请日：2016-08-01
发明人： Sherry Bullens , Stuart Bunting , Tianwei Chou , Augustus O. Okhamafe , Christopher P. Price , Daniel J. Wendt , Clarence Yap
CPC分类号： A61K38/2242 , A61K9/0019 , A61K9/19 , A61K38/1709 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26
摘要： The present disclosure provides for use of variants of C-type natriuretic peptide (CNP), and novel pharmaceutical compositions and formulations comprising CNP variant peptides for the treatment of skeletal dysplasias, one or more symptoms of skeletal dysplasias, such as long bone growth or growth velocity, and other disorders having a skeletal dysplasia and/or CNP-associated symptom or component.
摘要翻译： 本公开提供了C型利钠肽（CNP）的变体的使用，以及包含CNP变体肽的新型药物组合物和制剂，用于治疗骨骼发育不良，一种或多种骨骼发育不良症状，例如长骨生长或生长 速度和其他具有骨骼发育不良和/或CNP相关症状或组分的疾病。
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公开(公告)号：US12076372B2
公开(公告)日：2024-09-03
申请号：US18157573
申请日：2023-01-20
发明人： Sherry Bullens , Stuart Bunting , Tianwei Chou , Augustus O. Okhamafe , Christopher P. Price , Daniel J. Wendt , Clarence Yap
IPC分类号： A61K38/22 , A61K9/00 , A61K9/19 , A61K38/00 , A61K38/16 , A61K38/17 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/26
CPC分类号： A61K38/2242 , A61K9/0019 , A61K9/19 , A61K38/1709 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/20 , A61K47/26
摘要： The present disclosure provides for use of variants of C-type natriuretic peptide (CNP), and novel pharmaceutical compositions and formulations comprising CNP variant peptides for the treatment of skeletal dysplasias, one or more symptoms of skeletal dysplasias, such as long bone growth or growth velocity, and other disorders having a skeletal dysplasia and/or CNP-associated symptom or component.
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公开(公告)号：USRE48267E1
公开(公告)日：2020-10-20
申请号：US15646822
申请日：2017-07-11
发明人： Daniel J. Wendt , Shinong Long , Sianna Castillo , Christopher P. Price , Mika Aoyagi-Scharber , Michel Claude Vellard , Augustus O. Okhamafe
IPC分类号： A61K38/22 , A61K38/00 , A61K38/16 , C12P21/04 , C07K14/58 , A61K47/60 , A61K9/08 , A61K47/10 , A61K47/20 , A61K47/22 , A61K47/26
摘要： The present disclosure provides variants of C-type natriuretic peptide (CNP), pharmaceutical compositions comprising CNP variants, and methods of making CNP variants. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders, such as skeletal dysplasias (e.g., achondroplasia), and vascular smooth muscle disorders (e.g., restenosis and arteriosclerosis).
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公开(公告)号：US20200246433A1
公开(公告)日：2020-08-06
申请号：US16837905
申请日：2020-04-01
发明人： Sherry Bullens , Stuart Bunting , Tianwei Chou , Augustus O. Okhamafe , Christopher P. Price , Daniel J. Wendt , Clarence Yap
摘要： The present disclosure provides for use of variants of C-type natriuretic peptide (CNP), and novel pharmaceutical compositions and formulations comprising CNP variant peptides for the treatment of skeletal dysplasias, one or more symptoms of skeletal dysplasias, such as long bone growth or growth velocity, and other disorders having a skeletal dysplasia and/or CNP-associated symptom or component.
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公开(公告)号：US09907834B2
公开(公告)日：2018-03-06
申请号：US15225355
申请日：2016-08-01
发明人： Sherry Bullens , Stuart Bunting , Tianwei Chou , Augustus O. Okhamafe , Christopher P. Price , Daniel J. Wendt , Clarence Yap
IPC分类号： A61K38/00 , A61K38/22 , A61K9/19 , A61K47/12 , A61K47/26 , A61K47/18 , A61K47/10 , A61K9/00 , A61K38/17
CPC分类号： A61K38/2242 , A61K9/0019 , A61K9/19 , A61K38/1709 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26
摘要： The present disclosure provides for use of variants of C-type natriuretic peptide (CNP), and novel pharmaceutical compositions and formulations comprising CNP variant peptides for the treatment of skeletal dysplasias, one or more symptoms of skeletal dysplasias, such as long bone growth or growth velocity, and other disorders having a skeletal dysplasia and/or CNP-associated symptom or component.
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