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公开(公告)号：US07199129B2
公开(公告)日：2007-04-03
申请号：US10486536
申请日：2002-08-09
IPC分类号： A61K31/485 , C07D489/02
CPC分类号： A61K31/485 , C07D489/02 , C07D489/12 , C07F7/1804
摘要： The present disclosure concerns compounds of formula (I) and pharmaceutically acceptable salts, hydrates, solvates, pharmaceutically acceptable derivatives, pro-drugs, tautomers and/or isomers thereof. The disclosure also relates to processes for the preparation of compounds according to formula (I), pharmaceutical or veterinary compositions containing such compounds or methods of treatment and/or prophylaxis of a condition or symptom that is inhibited, reduced or alleviated by opioid receptor activation
摘要翻译： 本公开涉及式（I）的化合物及其药学上可接受的盐，水合物，溶剂化物，药学上可接受的衍生物，前药，互变异构体和/或异构体。 本公开还涉及制备根据式（I）的化合物的方法，含有这些化合物的药物或兽药组合物或治疗和/或预防被阿片受体激活抑制，减少或减轻的病症或症状的方法
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公开(公告)号：US20120238693A1
公开(公告)日：2012-09-20
申请号：US13487084
申请日：2012-06-01
申请人： Christopher Henry SUCH , Jim Patel , William Roy Jackson , Andrea Jane Robinson , Algirdas Kazimieras Serelis
发明人： Christopher Henry SUCH , Jim Patel , William Roy Jackson , Andrea Jane Robinson , Algirdas Kazimieras Serelis
IPC分类号： C08F110/00 , C11C3/00 , C09D123/00
CPC分类号： C09D165/00 , C07C67/333 , C08G61/00 , C11C3/00 , C07C69/533
摘要： The invention provides a method of preparing a crosslinked polymer, which method comprises polymerising branched polyunsaturated monomers by a metathesis polymerisation reaction, wherein the branched polyunsaturated monomers contain acyclic ethylenically unsaturated groups that are capable of undergoing polymerization by a metathesis reaction such that the metathesis polymerisation produces a crosslinked polymer and substantially no non-volatile ethylenically unsaturated by-products.
摘要翻译： 本发明提供了一种制备交联聚合物的方法，该方法包括通过易位聚合反应聚合支链多不饱和单体，其中支化多不饱和单体含有无环烯键式不饱和基团，其能够通过复分解反应进行聚合，使得易位聚合产生 交联聚合物和基本上不含非挥发性烯属不饱和副产物。
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13.发明申请公开(公告)号：US20100036089A1
公开(公告)日：2010-02-11
申请号：US12279383
申请日：2007-02-16
IPC分类号： C07K7/54
CPC分类号： C07K7/54 , C07B37/04 , C07C2/42 , C07C2/52 , C07C231/12 , C07C271/22 , C07C2603/18 , C07K1/006 , C07K1/06 , C07K1/1077 , C07C233/47 , C07C233/83 , C07C233/85 , C07C233/82
摘要： The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds contain a turn-inducing group between the pair of cross-metathesisable groups to facilitate the cross-metathesis.
摘要翻译： 本发明涉及在有机化合物中形成二桥桥的方法。 这涉及在有机化合物上使用一对互补易位基团，并在微波辐射条件下使化合物进行交叉复分解。 替代方案中，化合物在一对交叉易位组之间含有转向诱导基团，以促进交叉复分解。
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公开(公告)号：US20090186976A1
公开(公告)日：2009-07-23
申请号：US11988180
申请日：2006-06-30
申请人： Christopher Henry Such , Jim Patel , William Roy Jackson , Andrea Jane Robinson , Algirdas Kazimieras Serelis
发明人： Christopher Henry Such , Jim Patel , William Roy Jackson , Andrea Jane Robinson , Algirdas Kazimieras Serelis
IPC分类号： C09F1/04 , C08F22/26 , C08F2/00 , C08F4/42 , C07C45/28 , C07C49/203 , C07C53/00 , C07C69/52 , C07C209/22 , C08F20/52
CPC分类号： C09D165/00 , C07C67/333 , C08G61/00 , C11C3/00 , C07C69/533
摘要： The invention provides a method of preparing a crosslinked polymer, which method comprises polymerising branched polyunsaturated monomers by a metathesis polymerisation reaction, wherein the branched polyunsaturated monomers contain acyclic ethylenically unsaturated groups that are capable of undergoing polymerization by a metathesis reaction such that the metathesis polymerisation produces a crosslinked polymer and substantially no non-volatile ethylenically unsaturated by-products.
摘要翻译： 本发明提供了一种制备交联聚合物的方法，该方法包括通过易位聚合反应聚合支链多不饱和单体，其中支化多不饱和单体含有无环烯键式不饱和基团，其能够通过复分解反应进行聚合，使得易位聚合产生 交联聚合物和基本上不含非挥发性烯属不饱和副产物。
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