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公开(公告)号：US10769240B2
公开(公告)日：2020-09-08
申请号：US15311833
申请日：2015-04-30
Applicant: Brainlab AG
Inventor： Stefan Vilsmeier , Bálint Varkuti
Abstract: The present invention relates to a medical data processing method of determining an outcome quality of a medical procedure, the method comprising the following steps which are constituted to be executed by a computer: a) acquiring (S1) pre-completion medical image data describing an anatomical structure of a patient's body in a state before the medical procedure has been completed on the anatomical structure, the anatomical structure being subject to the medical procedure; b) acquiring (S1) pre-completion non-image medical data describing a state and medical history of the patient before the medical procedure has been completed on the anatomical structure; c) acquiring (S2) medical procedure planning data describing a plan for execution of the medical procedure to be carried out on the anatomical structure; d) determining (S2), based on the pre-completion medical image data and the medical procedure planning data, procedure application describing an application of the medical procedure planning data to the pre-completion medical image data; e) acquiring (S5) post-completion non-image medical data describing a state and medical history of the patient after the medical procedure has been completed on the anatomical structure; f) acquiring (S5) post-completion medical image data describing the anatomical structure in a state after the medical procedure has been completed on the anatomical structure; g) determining (S6, S7), based on the procedure application data and the pre-completion non-image medical data and the post-completion non-image medical data and the post-completion medical image data, outcome quality data comprising a quality measure describing a quality of the outcome of the medical procedure, the quality measure for example being specific to the indication in question, properties of the patient and the executive medical entity.
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公开(公告)号：US09639938B2
公开(公告)日：2017-05-02
申请号：US14437784
申请日：2013-06-28
Applicant: Brainlab AG
Inventor： Andreas Blumhofer , Bálint Varkuti , Jens Schmaler
CPC classification number: G06T7/0012 , G06F19/00 , G06F19/321 , G06T3/0056 , G06T7/30 , G06T7/32 , G06T7/38 , G06T11/008 , G06T2207/10004 , G06T2207/10076 , G06T2207/10081 , G06T2207/10084 , G06T2207/10088 , G06T2207/10116 , G06T2207/20081 , G06T2207/20104 , G06T2207/20128 , G06T2207/20221 , G06T2207/30004 , G06T2207/30196 , G16H50/50
Abstract: The present invention relates to a medical data processing method of transforming a representation of an anatomical structure of a patient in a first imaging modality into a representation of the anatomical structure in a second, other imaging modality, the method being constituted to be executed by a computer and comprising the following steps: acquiring first modality image data describing the first modality medical image containing the representation of the anatomical structure in the first imaging modality; acquiring atlas data describing a first modality atlas image describing a general structure of the anatomical structure in the first imaging modality, the atlas data containing information about the representation of the general structure in the second imaging modality; determining, based on the first modality image data and the atlas data, a first matching transformation between the first modality medical image and the first modality atlas image; determining, based on the first matching transformation and the first modality atlas image and the information about the representation of the general structure in the second imaging modality second modality, a second modality image representation of the first modality medical image.
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公开(公告)号：US20160232655A1
公开(公告)日：2016-08-11
申请号：US15024542
申请日：2013-09-30
Applicant: BRAINLAB AG
Inventor： Rainer Lachner , Bálint Varkuti , Andreas Blumhofer
IPC: G06T7/00
CPC classification number: G06T7/337 , G06T7/344 , G06T2207/10072 , G06T2207/10116 , G06T2207/20128 , G06T2207/20221 , G06T2207/30012 , G06T2207/30016
Abstract: A medical data processing method of determining a virtual image (2) of a part of a patient's body (4), the method being constituted to be executed by a computer and comprising the following steps: a) acquiring (S1) patient image data describing at least two two-dimensional patient images (1) of anatomical body parts (3) of the patient's body (4); b) acquiring (S2) atlas data describing a general structure (5) of at least part of the patient's body comprising correspondence parts corresponding to the anatomical body parts (3); c) acquiring correspondence part position data describing the positions of the correspondence parts in the general structure (5); determining (S4.1, S4.2, S4.3), based on the patient image data and the atlas data and the correspondence part position data, virtual image data describing a two-dimensional virtual image (2) of a part (21, 22) of the general structure (5) having a position in the general structure (5) which lies between the positions of the correspondence parts.
Abstract translation: 一种用于确定患者身体（4）的一部分的虚拟图像（2）的医疗数据处理方法，所述方法被构造成由计算机执行，并且包括以下步骤：a）获取（S1）描述的患者图像数据 患者身体（4）的解剖体部分（3）的至少两个二维患者图像（1）; b）获取（S2）描述包括对应于解剖体部分（3）的对应部分的患者身体的至少一部分的一般结构（5）的图形数据。 c）获取描述一般结构（5）中对应部分的位置的对应部位位置数据; 基于患者图像数据和图谱数据和对应部位位置数据确定（S4.1，S4.2，S4.3），描述部分（21）的二维虚像（2）的虚拟图像数据 ，具有在通用结构（5）中位于所述对应部件的位置之间的位置的通用结构（5）的端部（22）。
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14.发明授权公开(公告)号：US11020004B2
公开(公告)日：2021-06-01
申请号：US16478081
申请日：2017-02-28
Applicant: Brainlab AG
Inventor： Bálint Varkuti
Abstract: Disclosed is a computer-implemented medical data processing method for planning a position of an electric stimulation device for neurostimulation of at least two target regions (TV1, . . . , TVN) disposed in an anatomical body part of a patient's body, the electric stimulation device (7) comprising at least two electric contacts, the method comprising executing, on at least one processor of at least one computer (3), steps of: a) acquiring (S1.1), at the at least one processor, medical image data describing a digital image of the anatomical body part, wherein the anatomical body part contains at least two target regions (TV1, . . . , TVN); b) determining (S1.2), by the at least one processor and based on the medical image data, target position data describing a position of each target region (TV1, . . . , TVN) in the anatomical body part; c) acquiring (S1.3), at the at least one processor, electric stimulation device geometry data describing a distance between the at least two contacts of the electric stimulation device (7); d) determining (S1.4), by the at least one processor and based on the target position data, target distance data describing a distance between each pair of the at least two target regions; e) determining (S1.5), by the at least one processor and based on the target position data and the target distance data and the electric stimulation device geometry data, electric stimulation device position data describing a stimulation position which is a relative position between the at least two target regions (TV1, . . . , TVN) and the electric stimulation device (7) which allows for stimulation of the at least two target regions (TV1, . . . , TVN) by the electric stimulation device (7).
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15.发明授权公开(公告)号：US10765332B2
公开(公告)日：2020-09-08
申请号：US15569535
申请日：2015-04-29
Applicant: Brainlab AG
Inventor： Christian Harrer , Stephan Mittermeyer , Bálint Varkuti
IPC: A61B5/00 , A61B5/024 , A61B5/0452 , A61B5/0245
Abstract: The invention relates to a computer-implemented medical data processing method for determining a heartbeat signal describing the heartbeat of a patient in the time domain, the method comprising executing, on a processor of a computer, steps of: a) acquiring, at the processor, acceleration measurement data describing an acceleration in the time domain of an anatomical body part measured on an external surface of the anatomical body part; b) determining, by the processor, component analysis data describing a result of an independent component analysis in the time domain of the acceleration measurement data; c) acquiring, at the processor, heartbeat template data describing template shapes of heartbeat in the time domain; d) determining, by the processor and based on the component analysis data and the heartbeat template data, recurrent shape data describing a recurrence of certain signal shapes in the component analysis data; e) determining, based on the recurrent shape data, heartbeat signal data describing a time series of the heartbeat.
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Patent Agency Ranking
公开(公告)号：US20200022650A1
公开(公告)日：2020-01-23
申请号：US16336001
申请日：2017-11-08
Applicant: Brainlab AG
Inventor： Bálint Varkuti
Abstract: Disclosed is a computer-implemented medical data processing method for determining a stimulated nerve fibre disposed in an anatomical body part of a patient's body, the method comprising executing, on at least one processor of at least one computer, steps of: a) acquiring, at the at least one processor, medical image data describing a digital image of the anatomical body part, wherein the anatomical body part contains at least one nerve fibre extending in a direction between an internal part of the anatomical body part and a substantially exterior part of the anatomical body part; b) acquiring, at the at least one processor, atlas data describing an image-based model of the anatomical body part including a representation of the at least one nerve fibre; c) determining, by the at least one processor and based on the medical image data and the atlas data, exterior part data describing an association between the exterior part and the nerve fibre; d) acquiring, at the at least one processor, stimulation signal data describing a predetermined applied stimulation signal applied to, based on the exterior part data, the exterior part; e) acquiring, at the at least one processor, check signal data describing an emitted stimulation signal emitted by the nerve fibre; f) determining, by the at least one processor and based on the stimulation signal data and the check signal data, correspondence measure data describing a measure of correspondence between the applied stimulation signal and the emitted stimulation signal.
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公开(公告)号：US20170177827A1
公开(公告)日：2017-06-22
申请号：US15431575
申请日：2017-02-13
Applicant: Brainlab AG
Inventor： Stefan Achatz , Bálint Varkuti
CPC classification number: A61N1/0534 , A61N1/36185 , A61N1/37235 , A61N1/37241 , A61N1/37247 , G06F16/50 , G06F19/321 , G16H50/50
Abstract: Disclosed is a computer-implemented method for determining a coverage of a target anatomical structure by an electric stimulation field, the method comprising executing, on at least one processor of at least one computer, steps of: a) acquiring patient image data describing a medical image of the anatomical body part of a patient, wherein the anatomical body part includes the target anatomical structure b) acquiring atlas data describing a model of the anatomical body part and information about the position of a model target structure in the model of the anatomical body part, the model target structure corresponding to the target anatomical structure; c) determining, based on the patient image data and the atlas data, target structure position data describing a position of the target anatomical structure in the medical image of the anatomical body part of the patient; d) acquiring, electrode position data describing a relative position between a position of an electrode and a position of the anatomical body part of the patient as it is described by the patient image data; e) acquiring stimulation field data describing an electric stimulation field around the position of the electrode; f) determining, based on the patient image data and the atlas data and the electrode position data and the stimulation field data, target coverage data describing a coverage of the target anatomical structure by the electric stimulation field.
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公开(公告)号：US20170103173A1
公开(公告)日：2017-04-13
申请号：US15311833
申请日：2015-04-30
Applicant: Brainlab AG
Inventor： Stefan Vilsmeier , Bálint Varkuti
IPC: G06F19/00
CPC classification number: G06F19/321 , G06F19/324 , G06F19/325 , G16H40/63 , G16H50/20 , G16H50/70
Abstract: The present invention relates to a medical data processing method of determining an outcome quality of a medical procedure, the method comprising the following steps which are constituted to be executed by a computer: a) acquiring (S1) pre-completion medical image data describing an anatomical structure of a patient's body in a state before the medical procedure has been completed on the anatomical structure, the anatomical structure being subject to the medical procedure; b) acquiring (S1) pre-completion non-image medical data describing a state and medical history of the patient before the medical procedure has been completed on the anatomical structure; c) acquiring (S2) medical procedure planning data describing a plan for execution of the medical procedure to be carried out on the anatomical structure; d) determining (S2), based on the pre-completion medical image data and the medical procedure planning data, procedure application describing an application of the medical procedure planning data to the pre-completion medical image data; e) acquiring (S5) post-completion non-image medical data describing a state and medical history of the patient after the medical procedure has been completed on the anatomical structure; f) acquiring (S5) post-completion medical image data describing the anatomical structure in a state after the medical procedure has been completed on the anatomical structure; g) determining (S6, S7), based on the procedure application data and the pre-completion non-image medical data and the post-completion non-image medical data and the post-completion medical image data, outcome quality data comprising a quality measure describing a quality of the outcome of the medical procedure, the quality measure for example being specific to the indication in question, properties of the patient and the executive medical entity.
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公开(公告)号：US20160284082A1
公开(公告)日：2016-09-29
申请号：US15034077
申请日：2013-11-05
Applicant: BRAINLAB AG
Inventor： Bálint Varkuti
CPC classification number: G06T7/0012 , A61B5/055 , A61B5/4064 , A61B6/032 , A61B6/037 , A61B6/481 , A61B6/501 , A61B8/0808 , A61B8/488 , G06F17/16 , G06F19/00 , G06F19/321 , G06T17/005 , G06T2207/10081 , G06T2207/10088 , G06T2207/10092 , G06T2207/10104 , G06T2207/30016 , G06T2207/30241 , G06T2210/41 , G16H50/50
Abstract: The invention relates to a medical data processing method for determining a vulnerability field of a brain of a patient, the steps of the method being constituted to be executed by a computer and comprising: a) acquiring a nerve-indicating dataset comprising information about the brain of the patient suitable for identifying neural fibres in the brain of the patient; b) determining nodes within the brain preferably being neuron-rich grey matter parts of the brain; c) determining the axonal linkage of the nodes based on the nerve-indicating dataset to obtain edges connecting the nodes, the nodes and edges constituting a connectivity graph; d) determining a weight for each of the edges depending on centrality graph theoretical statistical measure of the respective edge in the connectivity graph; e) determining, for each of the edges, which voxels in a dataset of the brain of the patient belong to the edges or are passed by the edges and assigning or adding the determined weight of the respective edges to all of the voxels belonging to the respective edge to obtain a weighted voxel-based dataset of the brain of the patient defining the vulnerability field of the brain.
Abstract translation: 本发明涉及一种用于确定患者脑的脆弱性领域的医疗数据处理方法，该方法的步骤被构造为由计算机执行，并且包括：a）获取包含关于脑的信息的神经指示数据集 适合于鉴别患者脑部神经纤维的患者; b）确定脑内的节点优选地是脑的神经元丰富的灰质部分; c）基于神经指示数据集来确定节点的轴突连接，以获得连接节点，构成连通图的节点和边缘的边缘; d）根据连通性图中相应边缘的中心图理论统计量度确定每个边缘的权重; e）为每个边缘确定患者的脑的数据集中的哪些体素属于边缘或被边缘通过，并且将所确定的各个边的权重分配或添加到属于所述边缘的所有体素 相应的边缘以获得定义脑的脆弱性区域的患者的脑的加权基于体素的数据集。
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公开(公告)号：US11495345B2
公开(公告)日：2022-11-08
申请号：US16828484
申请日：2020-03-24
Applicant: Brainlab AG
Inventor： Stefan Achatz , Bálint Varkuti
Abstract: A system is disclosed for determining a coverage of a target anatomical structure by an electric stimulation field. The system includes a computer to acquire patient image data and the atlas data, determine, based on the patient image data and the atlas data, target structure position data describing a position of the target anatomical structure in the medical image of the anatomical body part of the patient. The system also acquires electrode position data and stimulation field data describing an electric stimulation field around the position of the electrode. The system also includes an electrode configuring device for adjusting an emission configuration of the electrode.
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