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11.发明申请公开(公告)号：US20130190380A1
公开(公告)日：2013-07-25
申请号：US13532254
申请日：2012-06-25
IPC分类号： C12N15/113
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.
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公开(公告)号：US20110213011A1
公开(公告)日：2011-09-01
申请号：US13035772
申请日：2011-02-25
IPC分类号： A61K31/7088 , C07H21/00 , A61P17/02 , A61P43/00
CPC分类号： A61K31/7088
摘要： Provided are compounds capable of inhibiting SMAD3 and compositions containing same as well as methods using such compounds for treating fibrosis and scarring.
摘要翻译： 提供能够抑制SMAD3的化合物和含有它们的组合物以及使用这些化合物治疗纤维化和瘢痕形成的方法。
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公开(公告)号：US20100056607A1
公开(公告)日：2010-03-04
申请号：US12374635
申请日：2007-07-18
IPC分类号： A61K31/7088 , C07H21/04 , C12N5/02
CPC分类号： C12N15/1135 , C12N2310/11
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of HBXIP in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
摘要翻译： 本文公开了用于调节细胞，组织或动物中HBXIP表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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公开(公告)号：US07148204B2
公开(公告)日：2006-12-12
申请号：US10302262
申请日：2002-11-21
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3233 , C12N2310/334 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3525
摘要： Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x expression and for treatment of diseases associated with expression of bcl-x are also provided. Methods of sensitizing cells to apoptotic stimuli are also provided.
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公开(公告)号：US06172216B2
公开(公告)日：2001-01-09
申请号：US09167921
申请日：1998-10-07
IPC分类号： C07H2102
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3233 , C12N2310/334 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3525
摘要： Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x expression and for treatment of diseases associated with expression of bcl-x are also provided.
摘要翻译： 提供组合物和方法用于调节bcl-x的表达。 优选靶向编码bcl-x的核酸的反义化合物，特别是反义寡核苷酸。 还提供了使用这些化合物调节bcl-x表达和治疗与bcl-x表达有关的疾病的方法。
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公开(公告)号：US08772260B2
公开(公告)日：2014-07-08
申请号：US13584573
申请日：2012-08-13
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.
摘要翻译： 本发明提供了包含能够抑制表达结缔组织因子的修饰寡核苷酸和含有其的组合物的化合物，以及治疗过度放射性疾病和纤维化疾病的方法，以及使用这些化合物减少伤口愈合引起的瘢痕形成。
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公开(公告)号：US20130190382A1
公开(公告)日：2013-07-25
申请号：US13584573
申请日：2012-08-13
IPC分类号： C12N15/113
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.
摘要翻译： 本发明提供了包含能够抑制表达结缔组织因子的修饰寡核苷酸和含有其的组合物的化合物，以及治疗过度放射性疾病和纤维化疾病的方法，以及使用这些化合物减少伤口愈合引起的瘢痕形成。
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18.发明授权Antisense oligonucleotides directed against connective tissue growth factor and uses thereof 有权针对结缔组织生长因子的反义寡核苷酸及其用途公开(公告)号：US08252762B2
公开(公告)日：2012-08-28
申请号：US12547474
申请日：2009-08-25
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.
摘要翻译： 本发明提供了包含能够抑制表达结缔组织因子的修饰寡核苷酸和含有其的组合物的化合物，以及治疗过度放射性疾病和纤维化疾病的方法，以及使用这些化合物减少伤口愈合引起的瘢痕形成。
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公开(公告)号：US08198253B2
公开(公告)日：2012-06-12
申请号：US12374635
申请日：2007-07-18
CPC分类号： C12N15/1135 , C12N2310/11
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of HBXIP in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
摘要翻译： 本文公开了用于调节细胞，组织或动物中HBXIP表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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公开(公告)号：US20110172296A1
公开(公告)日：2011-07-14
申请号：US13005508
申请日：2011-01-12
IPC分类号： A61K31/7088 , C07H21/04 , C07H21/02 , A61P17/02
CPC分类号： A61K31/7088 , C12N15/1136 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/341 , C12N2310/3521 , C12N2310/3525
摘要： Provided are compounds capable of inhibiting expression of TGF-beta 1 and compositions containing same as well as methods using such compounds for treating fibrotic diseases including the reduction of scarring resulting from wound healing.
摘要翻译： 提供能够抑制TGF-β1的表达的化合物及其含有组合物的化合物以及使用这些化合物治疗纤维化疾病的方法，包括减少由伤口愈合导致的瘢痕形成。
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