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公开(公告)号：US07148204B2
公开(公告)日：2006-12-12
申请号：US10302262
申请日：2002-11-21
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3233 , C12N2310/334 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3525
摘要： Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x expression and for treatment of diseases associated with expression of bcl-x are also provided. Methods of sensitizing cells to apoptotic stimuli are also provided.
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公开(公告)号：US06214986B1
公开(公告)日：2001-04-10
申请号：US09323743
申请日：1999-06-02
IPC分类号： C07H2104
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3233 , C12N2310/334 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3525
摘要： Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x expression and for treatment of diseases associated with expression of bcl-x are also provided. Methods of sensitizing cells to apoptotic stimuli are also provided.
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公开(公告)号：US06172216B2
公开(公告)日：2001-01-09
申请号：US09167921
申请日：1998-10-07
IPC分类号： C07H2102
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3233 , C12N2310/334 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3525
摘要： Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred. Methods of using these compounds for modulation of bcl-x expression and for treatment of diseases associated with expression of bcl-x are also provided.
摘要翻译： 提供组合物和方法用于调节bcl-x的表达。 优选靶向编码bcl-x的核酸的反义化合物，特别是反义寡核苷酸。 还提供了使用这些化合物调节bcl-x表达和治疗与bcl-x表达有关的疾病的方法。
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4.发明授权Isolation and propagation of a human herpesvirus derived from AIDS-associated Kaposi's sarcoma cells 失效源自艾滋病相关卡波西氏肉瘤细胞的人类疱疹病毒的分离和繁殖
公开(公告)号：US6114110A
公开(公告)日：2000-09-05
申请号：US585588
申请日：1996-01-16
申请人： Gary J. Nabel , Brian J. Nickoloff
发明人： Gary J. Nabel , Brian J. Nickoloff
IPC分类号： A61K39/245 , C12N7/00 , G01N33/50 , G01N33/569 , C12Q1/70 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/5091 , A61K39/12 , A61K39/245 , C12N7/00 , G01N33/5008 , G01N33/5011 , G01N33/5064 , G01N33/56994 , C12N2710/16421 , C12N2710/16434
摘要： This present invention demonstrates the presence of a replication-competent herpesvirus associated with AIDS-associated Kaposi's sarcoma cells, vaccines derived therefrom, methods for diagnosing for Kaposi sarcoma, and methods for screening for antiviral drugs effective against human herpesvirus.
摘要翻译： 本发明证明存在与AIDS相关的卡波西氏肉瘤细胞，由其衍生的疫苗，用于诊断卡波西肉瘤的方法，以及用于筛选针对人类疱疹病毒的抗病毒药物的方法的与复制有关的疱疹病毒。
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公开(公告)号：US5707624A
公开(公告)日：1998-01-13
申请号：US253728
申请日：1994-06-03
CPC分类号： C07K16/32 , C07K16/18 , C07K16/22 , C07K16/248 , A61K38/00 , C07K2317/73
摘要： Methods of treating Kaposi's sarcoma (KS) by inhibiting the effect of scatter factor (SF), also known as hepatocyte growth factor (HGF), are provided. The methods of the present invention include antibody therapy wherein an antibody to SF is introduced into a patient to decrease active SF levels thereby decreasing the incidence of new tumors as well as leading to regression of established tumors by blocking SF-mediated tumor cell proliferation and neovascularization. The present invention further provides methods of inhibiting the effects of SF by introducing into a patient means for inhibiting binding of SF to the SF receptor, the c-met proto-oncogen. Means for inhibiting SF binding to the receptor include introducing into a patient an antibody to the c-met receptor or introducing a non-stimulatory ligand that will bind and thereby inhibit the receptor.
摘要翻译： 提供了通过抑制散射因子（SF）（也称为肝细胞生长因子（HGF））的作用来治疗卡波西氏肉瘤（KS）的方法。 本发明的方法包括抗体治疗，其中将SF抗体引入患者以降低活性SF水平，从而降低新肿瘤的发生率，并通过阻断SF介导的肿瘤细胞增殖和新生血管形成导致建立的肿瘤的消退 。 本发明进一步提供了通过向患者引入SF抑制SF与SF受体，c-met原癌基因的结合来抑制SF的作用的方法。 用于抑制SF与受体结合的方法包括向患者施用对c-met受体的抗体或引入将结合并从而抑制受体的非刺激性配体。
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