公开(公告)号：US12188047B2

公开(公告)日：2025-01-07

申请号：US15771046

申请日：2016-10-26

Applicant: CELL CURE NEUROSCIENCES LTD. ,  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： Benjamin Eithan Reubinoff ,  Orna Singer ,  Osnat Bohana-Kashtan ,  Ofer Wiser

IPC: C12N5/079 ,  C12N5/00 ,  C12N5/0735 ,  G01N33/53

Abstract: A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.

公开(公告)号：US20210388316A1

公开(公告)日：2021-12-16

申请号：US17355093

申请日：2021-06-22

Applicant: Cell Cure Neurosciences LTD

Inventor： Osnat Bohana-Kashtan ,  Ofer Wiser

IPC: C12N5/079

Abstract: A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.

公开(公告)号：US11090337B2

公开(公告)日：2021-08-17

申请号：US15750049

申请日：2016-08-04

Applicant: CELL CURE NEUROSCIENCES LTD

Inventor： Osnat Bohana-Kashtan

IPC: A61K35/30 ,  C12N5/07 ,  C12N5/079 ,  C12N5/0793 ,  A01N1/02

Abstract: A method of generating photoreceptors is disclosed. Cell populations comprising photoreceptors and uses thereof are also disclosed.

公开(公告)号：US11891622B2

公开(公告)日：2024-02-06

申请号：US15539473

申请日：2015-12-30

Applicant: Cell Cure Neurosciences Ltd.

Inventor： Osnat Bohana-Kashtan ,  Lior Ann Rosenberg Belmaker ,  Ofer Wiser

IPC: C12N5/079 ,  A61K35/30

CPC classification number: C12N5/0621 ,  A61K35/30 ,  C12N2500/02 ,  C12N2500/38 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/16 ,  C12N2506/02 ,  C12N2533/52

Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.

公开(公告)号：US20230051803A1

公开(公告)日：2023-02-16

申请号：US17883263

申请日：2022-08-08

Applicant: CELL CURE NEUROSCIENCES LTD.

Inventor： Osnat Bohana-Kashtan ,  Lior Ann Rosenberg Belmaker ,  Ofer Wiser

IPC: C12N5/079 ,  A61K35/30

Abstract: A method of qualifying whether a cell population is a suitable therapeutic for treating an eye condition is disclosed. The method comprises analyzing co-expression of premelanosome protein (PMEL17) and at least one polypeptide selected from the group consisting of cellular retinaldehyde binding protein (CRALBP), lecithin retinol acyltransferase (LRAT) and sex determining region Y-box 9 (SOX 9) in the population of cells.

公开(公告)号：US20220154141A1

公开(公告)日：2022-05-19

申请号：US17546013

申请日：2021-12-08

Applicant: Cell Cure Neurosciences Ltd.

Inventor： Osnat Bohana-Kashtan ,  Lior Ann Rosenberg Belmaker ,  Ofer Wiser

IPC: C12N5/079 ,  A61K35/30

Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.

公开(公告)号：US20180016553A1

公开(公告)日：2018-01-18

申请号：US15539473

申请日：2015-12-30

Applicant: Cell Cure Neurosciences Ltd.

Inventor： Osnat Bohana-Kashtan ,  Lior Ann Rosenberg Belmaker ,  Ofer Wiser

IPC: C12N5/079 ,  A61K35/30

CPC classification number: C12N5/0621 ,  A61K35/30 ,  C12N2500/02 ,  C12N2500/38 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/16 ,  C12N2506/02 ,  C12N2533/52

Abstract: A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.

公开(公告)号：US20180011092A1

公开(公告)日：2018-01-11

申请号：US15539514

申请日：2015-12-30

Applicant: Cell Cure Neurosciences Ltd.

Inventor： Osnat Bohana-Kashtan ,  Lior Ann Rosenberg Belmaker ,  Ofer Wiser

IPC: G01N33/569 ,  A61K35/30 ,  C12N5/079

CPC classification number: G01N33/56966 ,  A61K35/30 ,  A61K35/545 ,  C12N5/0621 ,  C12N2500/02 ,  C12N2500/38 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/16 ,  C12N2501/999 ,  C12N2502/1323 ,  C12N2506/02 ,  C12N2509/00 ,  C12N2533/54 ,  G01N33/57407 ,  G01N2333/47 ,  G01N2333/4703 ,  G01N2500/10

Abstract: A method of qualifying whether a cell population is a suitable therapeutic for treating an eye condition is disclosed. The method comprises analyzing co-expression of premelanosome protein (PMEL17) and at least one polypeptide selected from the group consisting of cellular retinaldehyde binding protein (CRALBP), lecithin retinol acyltransferase (LRAT) and sex determining region Y-box 9 (SOX 9) in the population of cells.