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公开(公告)号：US20210388316A1
公开(公告)日：2021-12-16
申请号：US17355093
申请日：2021-06-22
发明人： Osnat Bohana-Kashtan , Ofer Wiser
IPC分类号： C12N5/079
摘要： A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.
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公开(公告)号：US20220169982A1
公开(公告)日：2022-06-02
申请号：US17552743
申请日：2021-12-16
摘要： A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
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公开(公告)号：US20210332325A1
公开(公告)日：2021-10-28
申请号：US17323441
申请日：2021-05-18
摘要： A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
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公开(公告)号：US20230119816A1
公开(公告)日：2023-04-20
申请号：US18081476
申请日：2022-12-14
发明人： Nir Netzer , Ofer Wiser , Bat Shahaf , Orit Gamburg , Lior Rosenberg Belmaker , Dana Hayoun Neeman , Osnat Bohana Kashtan
摘要： Presented herein are ready to administer (RTA) retinal pigment epithelium (RPE) cell therapy compositions for the treatment of retinal degenerative diseases and injuries. A method of formulating human RPE cells for administration to a subject directly after thawing and of formulating RPE cell therapy compositions for cryopreservation and administration of the cryopreserved composition to a subject subsequent to thawing are also presented. In another aspect, the RTA composition may be formulated as a thaw and inject (TAI) composition, whereby the composition is administered by injection subsequent to thawing.
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公开(公告)号：US20220169981A1
公开(公告)日：2022-06-02
申请号：US17546011
申请日：2021-12-08
摘要： A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
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公开(公告)号：US11066642B2
公开(公告)日：2021-07-20
申请号：US15750108
申请日：2016-08-04
发明人： Osnat Bohana-Kashtan , Ofer Wiser
IPC分类号： C12N5/079
摘要： A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.
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公开(公告)号：US20180230426A1
公开(公告)日：2018-08-16
申请号：US15750108
申请日：2016-08-04
发明人： Osnat Bohana-Kashtan , Ofer Wiser
IPC分类号： C12N5/079
CPC分类号： C12N5/0621 , C12N2500/38 , C12N2500/98 , C12N2501/115 , C12N2501/15 , C12N2506/02 , C12N2533/52 , C12N2533/54
摘要： A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.
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公开(公告)号：US20240301351A1
公开(公告)日：2024-09-12
申请号：US18662758
申请日：2024-05-13
CPC分类号： C12N5/0621 , A61K35/30 , C12N2500/02 , C12N2500/38 , C12N2501/115 , C12N2501/15 , C12N2501/16 , C12N2506/02 , C12N2533/52
摘要： A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
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公开(公告)号：US20240285693A1
公开(公告)日：2024-08-29
申请号：US18424000
申请日：2024-01-26
发明人： Dana Hayoun Neeman , Ofer Wiser , Ravid Tikotzki , Lilach Alon
CPC分类号： A61K35/30 , C12N5/0621 , C12N2501/15 , C12N2506/02 , C12N2531/00
摘要： Presented herein are methods and compositions for expanding RPE cells with the use of a suspendable cell support matrix. Also provided are pharmaceutical compositions containing RPE cells, and methods of treating an eye disorder or disease using RPE cells.
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公开(公告)号：US11987810B2
公开(公告)日：2024-05-21
申请号：US17546013
申请日：2021-12-08
CPC分类号： C12N5/0621 , A61K35/30 , C12N2500/02 , C12N2500/38 , C12N2501/115 , C12N2501/15 , C12N2501/16 , C12N2506/02 , C12N2533/52
摘要： A population of human polygonal RPE cells is disclosed. At least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms. Methods of generating same are also disclosed.
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