公开(公告)号：US10584128B2

公开(公告)日：2020-03-10

申请号：US15850720

申请日：2017-12-21

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Alessandro Accetta ,  Fabio Rancati ,  Anna Maria Capelli ,  David Edward Clark ,  Patrizia Tisselli ,  Christine Edwards ,  Gurdip Bhalay

IPC: A61K31/519 ,  C07D487/04 ,  A61P11/06 ,  A61K9/00 ,  A61K45/06 ,  A61P11/00 ,  A61P37/00

Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and pulmonary arterial hypertension (PAH).

公开(公告)号：US09968604B2

公开(公告)日：2018-05-15

申请号：US15079740

申请日：2016-03-24

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Anna Maria Capelli ,  Matteo Biagetti ,  Alessandro Accetta

IPC: A61K31/519 ,  A61K31/52 ,  C07D403/12 ,  C07D405/12 ,  C07D473/34 ,  C07D487/04 ,  A61K31/506

CPC classification number: A61K31/506 ,  A61K31/519 ,  A61K31/52 ,  C07D403/12 ,  C07D405/12 ,  C07D473/34 ,  C07D487/04

Abstract: Chromene compounds of formula (I), defined herein, inhibit phosphoinositide 3-kinases (PI3K) and are useful for the treatment of disorders associated with a PI3K enzyme mechanism, such as asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis.