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公开(公告)号：US20180170939A1
公开(公告)日：2018-06-21
申请号：US15850720
申请日：2017-12-21
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Alessandro Accetta , Fabio Rancati , Anna Maria Capelli , David Edward Clark , Patrizia Tisselli , Christine Edwards , Gurdip Bhalay
IPC: C07D487/04 , A61K31/519 , A61K45/06 , A61K9/00 , A61P11/06
Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and pulmonary arterial hypertension (PAH).
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公开(公告)号：US20180215758A1
公开(公告)日：2018-08-02
申请号：US15883729
申请日：2018-01-30
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Alessandro Accetta , Fabio Rancati , Anna Maria Capelli , David Edward Clark , Patrizia Tisselli , Christine Edwards , Gurdip Bhalay , Arnaud Jean Francois Auguste Cheguillaume
IPC: C07D471/04 , C07D498/04 , C07D471/08 , A61K31/437 , A61K31/519 , A61K31/5377 , A61K31/5383 , A61K31/4375 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/444 , A61K31/439 , A61K31/501 , A61K31/498 , A61K9/00
Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
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公开(公告)号：US11147812B2
公开(公告)日：2021-10-19
申请号：US16639486
申请日：2018-09-05
Applicant: Chiesi Farmaceutici S.p.A.
Inventor： Alessandro Accetta , Anna Maria Capelli , Fabio Rancati , Gurdip Bhalay , Arnaud Jean Francois Auguste Cheguillaume , Christine Edwards , Patrizia Tisselli
IPC: C07D471/04 , A61K31/4995 , A61K31/496 , C07D487/08 , A61K9/00 , A61K31/437
Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are tyrosine analogues derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
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公开(公告)号：US20140179714A1
公开(公告)日：2014-06-26
申请号：US14177469
申请日：2014-02-11
Applicant: Chiesi Farmaceutici S.p.A.
Inventor： Toby Jonathan Blench , Christine Edwards , Robert Andrew Heald , Janusz Jozef Kulagowski , Jonathan Mark Sutton , Carmelida Capaldi
IPC: C07D487/04
CPC classification number: C07D487/04
Abstract: Compounds of formula (I): are useful as inhibitors of human neutrophil elastase.
Abstract translation: 式（I）化合物：可用作人中性粒细胞弹性蛋白酶的抑制剂。
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公开(公告)号：US11578068B2
公开(公告)日：2023-02-14
申请号：US16954968
申请日：2018-12-12
Applicant: Chiesi Farmaceutici S.p.A.
Inventor： Alessandro Accetta , Fabio Rancati , Christine Edwards , Elizabeth Anne Skidmore
IPC: C07D471/04 , A61K9/00 , A61K31/4375 , A61K31/444 , A61K45/06
Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are oxidazole derivatives, processes for preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
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Patent Agency Ranking
公开(公告)号：US09023855B2
公开(公告)日：2015-05-05
申请号：US14177469
申请日：2014-02-11
Applicant: Chiesi Farmaceutici S.p.A.
Inventor： Toby Jonathan Blench , Christine Edwards , Robert Andrew Heald , Janusz Jozef Kulagowski , Jonathan Mark Sutton , Carmelida Capaldi
IPC: A61K31/519 , C07D487/00 , C07D487/04
CPC classification number: C07D487/04
Abstract: Compounds of formula (I): are useful as inhibitors of human neutrophil elastase.
Abstract translation: 式（I）化合物：可用作人中性粒细胞弹性蛋白酶的抑制剂。
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公开(公告)号：US11725007B2
公开(公告)日：2023-08-15
申请号：US16954964
申请日：2018-12-12
Applicant: Chiesi Farmaceutici S.p.A.
Inventor： Alessandro Accetta , Fabio Rancati , Christine Edwards , Gurdip Bhalay , Patrizia Tisselli
IPC: C07D471/04 , A61K9/00 , A61K31/407 , A61K31/496 , A61K45/06
CPC classification number: C07D471/04 , A61K9/008 , A61K9/0075 , A61K9/0078 , A61K31/407 , A61K31/496 , A61K45/06
Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are meta tyrosine derivatives, processes for preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
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公开(公告)号：US11332468B2
公开(公告)日：2022-05-17
申请号：US16954977
申请日：2018-12-14
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Alessandro Accetta , Fabio Rancati , Christine Edwards , Andrea Nuzzi
IPC: C07D471/04 , C07D487/04 , C07D519/00 , A61K9/00 , A61K45/06
Abstract: The invention relates to compounds of formula I inhibiting Rho Kinase that are tyrosine analogues derivatives, processes of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
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公开(公告)号：US10954236B2
公开(公告)日：2021-03-23
申请号：US16656842
申请日：2019-10-18
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Alessandro Accetta , Fabio Rancati , Anna Maria Capelli , David Edward Clark , Patrizia Tisselli , Christine Edwards , Gurdip Bhalay , Arnaud Jean Francois Auguste Cheguillaume
IPC: A61P11/00 , C07D471/04 , C07D519/00 , C07D487/04 , A61K9/00 , A61K31/437 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/5377 , A61K31/5383 , C07D471/08 , C07D498/04
Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
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公开(公告)号：US10584128B2
公开(公告)日：2020-03-10
申请号：US15850720
申请日：2017-12-21
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Alessandro Accetta , Fabio Rancati , Anna Maria Capelli , David Edward Clark , Patrizia Tisselli , Christine Edwards , Gurdip Bhalay
IPC: A61K31/519 , C07D487/04 , A61P11/06 , A61K9/00 , A61K45/06 , A61P11/00 , A61P37/00
Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and pulmonary arterial hypertension (PAH).
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