公开(公告)号：US20230416233A1

公开(公告)日：2023-12-28

申请号：US18038977

申请日：2021-11-26

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Claudio FIORELLI ,  Paolo BRUNO ,  Matteo BIAGETTI ,  Charles BAKER-GLENN ,  Hervè VAN DE POËL

IPC: C07D403/12 ,  C07D417/14 ,  C07D401/14 ,  C07D403/14 ,  C07D401/12

CPC classification number: C07D403/12 ,  C07D417/14 ,  C07D401/14 ,  C07D403/14 ,  C07D401/12

Abstract: The present invention relates to compounds of formula (I) inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are (aza)quinoline 4-amines derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).

公开(公告)号：US20220227749A1

公开(公告)日：2022-07-21

申请号：US17615017

申请日：2020-05-28

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Paolo BRUNO ,  Matteo BIAGETTI ,  Claudio FIORELLI ,  Daniela PIZZIRANI ,  Daniele PALA ,  Paolo RONCHI ,  Charles BAKER-GLENN ,  Hervè VAN DE POËL ,  Kim Louise HIRST ,  Sara GUARIENTO

IPC: C07D417/12 ,  C07D405/14 ,  C07F5/02 ,  C07D417/14 ,  C07D403/14 ,  C07D403/12 ,  C07D413/12 ,  C07D401/12

Abstract: The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are amino quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).

公开(公告)号：US20160326147A1

公开(公告)日：2016-11-10

申请号：US15148225

申请日：2016-05-06

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Elisabetta ARMANI ,  Gabriele AMARI ,  Wesley BLACKABY ,  Herve VAN DE POEL ,  Charles BAKER-GLENN ,  Naimisha TRIVEDI

IPC: C07D409/12 ,  C07D409/14 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4545 ,  C07D453/02 ,  A61K31/439

CPC classification number: C07D409/12 ,  A61K31/439 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4545 ,  C07D409/14 ,  C07D453/02 ,  C07D471/08

Abstract: Compounds of formula (I) are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.

Abstract translation: 式（I）化合物既是磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，也可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。