公开(公告)号：US20140171414A1

公开(公告)日：2014-06-19

申请号：US14108904

申请日：2013-12-17

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Lilian ALCARAZ ,  Robert Andrew Heald ,  Jonathan Mark Sutton ,  Elisabetta Armani ,  Carmelida Capaldi

IPC: C07D487/04 ,  C07C309/20 ,  C07C309/29 ,  C07D453/02 ,  C07D487/08

CPC classification number: C07D487/04 ,  A61K9/0053 ,  A61K9/007 ,  C07C47/19 ,  C07C53/06 ,  C07C309/04 ,  C07C309/08 ,  C07C309/20 ,  C07C309/29 ,  C07D453/02 ,  C07D487/08 ,  C07D519/00

Abstract: Compounds of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for treating diseases and conditions in which HNE is implicated.

Abstract translation: 本文定义的式（I）化合物显示人嗜中性粒细胞弹性蛋白酶抑制性质，并且可用于治疗涉及HNE的疾病和病症。

公开(公告)号：US09868740B2

公开(公告)日：2018-01-16

申请号：US15317274

申请日：2014-06-12

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Lilian Alcaraz ,  Robert Andrew Heald ,  Jonathan Mark Sutton ,  Elisabetta Armani ,  Carmelida Capaldi

IPC: C07D487/04 ,  A61K31/519 ,  A61P11/06 ,  A61P11/08 ,  A61P11/12 ,  A61P11/00

CPC classification number: C07D487/04

Abstract: This invention relates to heterocyclic compounds, which are pyrimidinone derivatives having human neutrophil elastase inhibitory properties, and their use in therapy.

公开(公告)号：US09365577B2

公开(公告)日：2016-06-14

申请号：US14108904

申请日：2013-12-17

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Lilian Alcaraz ,  Robert Andrew Heald ,  Jonathan Mark Sutton ,  Elisabetta Armani ,  Carmelida Capaldi

IPC: C07D487/04 ,  A61K31/519 ,  C07C309/20 ,  C07C309/29 ,  C07D453/02 ,  C07D487/08

CPC classification number: C07D487/04 ,  A61K9/0053 ,  A61K9/007 ,  C07C47/19 ,  C07C53/06 ,  C07C309/04 ,  C07C309/08 ,  C07C309/20 ,  C07C309/29 ,  C07D453/02 ,  C07D487/08 ,  C07D519/00

Abstract: Pyrimidinone compounds defined herein exhibit human neutrophil elastase inhibitory properties and are useful for treating diseases and conditions in which HINE is implicated.

Abstract translation: 本文定义的嘧啶酮化合物显示人嗜中性粒细胞弹性蛋白酶抑制性质，并且可用于治疗涉及HINE的疾病和病症。

公开(公告)号：US09023855B2

公开(公告)日：2015-05-05

申请号：US14177469

申请日：2014-02-11

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Toby Jonathan Blench ,  Christine Edwards ,  Robert Andrew Heald ,  Janusz Jozef Kulagowski ,  Jonathan Mark Sutton ,  Carmelida Capaldi

IPC: A61K31/519 ,  C07D487/00 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: Compounds of formula (I): are useful as inhibitors of human neutrophil elastase.

Abstract translation: 式（I）化合物：可用作人中性粒细胞弹性蛋白酶的抑制剂。

公开(公告)号：US20140018345A1

公开(公告)日：2014-01-16

申请号：US13940555

申请日：2013-07-12

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Carmelida Capaldi ,  Robert Andrew Heald ,  Nicholas Charles Ray ,  Jonathan Mark Sutton

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds of formula (I): wherein R1, R2, R3, R5, R6, A1, A2, A3, A4 assume meanings as defined in formula (I) are inhibitors of neutrophil elastase.

Abstract translation: 式（I）化合物：其中R 1，R 2，R 3，R 5，R 6，A 1，A 2，A 3，A 4定义为式（I）中定义的含义是嗜中性粒细胞弹性蛋白酶抑制剂。