公开(公告)号：US09828382B2

公开(公告)日：2017-11-28

申请号：US15150749

申请日：2016-05-10

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Lilian Alcaraz ,  Robert Andrew Heald ,  Jonathan Mark Sutton ,  Elisabetta Armani ,  Carmelida Capaldi

IPC: C07D487/04 ,  A61K31/519 ,  A61P11/00 ,  A61P37/00 ,  C07C309/20 ,  C07C309/29 ,  C07D453/02 ,  C07D487/08 ,  A61K9/00 ,  C07C47/19 ,  C07C53/06 ,  C07C309/04 ,  C07C309/08 ,  C07D519/00

CPC classification number: C07D487/04 ,  A61K9/0053 ,  A61K9/007 ,  C07C47/19 ,  C07C53/06 ,  C07C309/04 ,  C07C309/08 ,  C07C309/20 ,  C07C309/29 ,  C07D453/02 ,  C07D487/08 ,  C07D519/00

Abstract: Pyrimidone compounds defined herein exhibit human neutrophil elastase inhibitory properties and are useful for treating diseases and condition in which HNE is implicated.

公开(公告)号：US09802919B1

公开(公告)日：2017-10-31

申请号：US15606313

申请日：2017-05-26

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Jonathan Mark Sutton ,  Robert Andrew Heald ,  Andrew Stephen Robert Jennings ,  Carmelida Capaldi ,  Elisabetta Armani

IPC: C07D403/04 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04 ,  C07D417/14 ,  A61K31/4178 ,  A61K31/4155 ,  A61K31/4196 ,  A61K31/454 ,  C07C309/29

CPC classification number: C07D403/04 ,  C07C309/29 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: Compounds of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for the treatment of disease or conditions in which HNE is implicated.

公开(公告)号：US20150166548A1

公开(公告)日：2015-06-18

申请号：US14571755

申请日：2014-12-16

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Lilian ALCARAZ ,  Jonathan Mark Sutton ,  Elisabetta Armani ,  Carmelida Capaldi

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Heterocyclic compounds and salts according to formula (I), which are pyrimidinone derivatives, described herein exhibit human neutrophil elastase inhibitory properties, and useful for treating diseases or conditions in which HNE is implicated.

Abstract translation: 本文所述的作为嘧啶酮衍生物的式（I）的杂环化合物和盐表现出人嗜中性粒细胞弹性蛋白酶抑制性质，并且可用于治疗涉及HNE的疾病或病症。

公开(公告)号：US10023558B2

公开(公告)日：2018-07-17

申请号：US15712366

申请日：2017-09-22

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Jonathan Mark Sutton ,  Robert Andrew Heald ,  Andrew Stephen Robert Jennings ,  Carmelida Capaldi ,  Elisabetta Armani

IPC: C07D403/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/454 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4196 ,  C07C309/29 ,  C07D403/14

Abstract: Compounds of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for the treatment of disease or conditions in which HNE is implicated.

公开(公告)号：US09573955B2

公开(公告)日：2017-02-21

申请号：US14571755

申请日：2014-12-16

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Lilian Alcaraz ,  Jonathan Mark Sutton ,  Elisabetta Armani ,  Carmelida Capaldi

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Heterocyclic compounds and salts according to formula (I), which are pyrimidinone derivatives, described herein exhibit human neutrophil elastase inhibitory properties, and useful for treating diseases or conditions in which HNE is implicated.

Abstract translation: 本文所述的作为嘧啶酮衍生物的式（I）的杂环化合物和盐表现出人嗜中性粒细胞弹性蛋白酶抑制性质，并且可用于治疗涉及HNE的疾病或病症。

公开(公告)号：US09409870B2

公开(公告)日：2016-08-09

申请号：US14953183

申请日：2015-11-27

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Elisabetta Armani ,  Carmelida Capaldi ,  Jonathan Mark Sutton ,  Robert Andrew Heald

IPC: A61K31/513 ,  C07D233/70 ,  C07D403/04 ,  C07D405/14 ,  C07D403/14 ,  C07C309/29 ,  C07C53/06 ,  C07D401/14

CPC classification number: C07D233/70 ,  C07C53/06 ,  C07C309/29 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14

Abstract: Compounds of formula (I) described herein are imidazolone derivatives having human neutrophil elastase (HNE) inhibitory properties and are useful for the treatment of diseases and conditions in which HNE is implicated.

Abstract translation: 本文所述的式（I）化合物是具有人嗜中性粒细胞弹性蛋白酶（HNE）抑制性质的咪唑啉酮衍生物，可用于治疗涉及HNE的疾病和病症。

公开(公告)号：US20140179714A1

公开(公告)日：2014-06-26

申请号：US14177469

申请日：2014-02-11

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Toby Jonathan Blench ,  Christine Edwards ,  Robert Andrew Heald ,  Janusz Jozef Kulagowski ,  Jonathan Mark Sutton ,  Carmelida Capaldi

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Compounds of formula (I): are useful as inhibitors of human neutrophil elastase.

Abstract translation: 式（I）化合物：可用作人中性粒细胞弹性蛋白酶的抑制剂。

公开(公告)号：US10172830B2

公开(公告)日：2019-01-08

申请号：US15606154

申请日：2017-05-26

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Jonathan Mark Sutton ,  Robert Andrew Heald ,  Andrew Stephen Robert Jennings ,  Carmelida Capaldi ,  Elisabetta Armani

IPC: A61K31/4152 ,  A61K31/4155 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/14 ,  A61K31/277 ,  C07D231/44 ,  C07D249/08 ,  C07D401/04

Abstract: Pyrazolone derivatives of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for the treatment of diseases or conditions in which HNE is implicated.

公开(公告)号：US09487528B2

公开(公告)日：2016-11-08

申请号：US14731786

申请日：2015-06-05

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Elisabetta Armani ,  Carmelida Capaldi ,  Jonathan Mark Sutton ,  Robert Andrew Heald

IPC: C07D487/04 ,  A61K31/519

CPC classification number: C07D487/04 ,  A61K9/0075 ,  A61K9/008 ,  A61K31/519

Abstract: Compounds of formula (I), described herein, exhibit human neutrophil elastase inhibitory properties, and are useful for the treatment of diseases and conditions in which HNE is implicated.

Abstract translation: 本文所述的式（I）化合物显示人嗜中性粒细胞弹性蛋白酶抑制性质，并且可用于治疗涉及HNE的疾病和病症。

公开(公告)号：US09199984B2

公开(公告)日：2015-12-01

申请号：US13940555

申请日：2013-07-12

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Carmelida Capaldi ,  Robert Andrew Heald ,  Nicholas Charles Ray ,  Jonathan Mark Sutton

IPC: C07D401/02 ,  C07D401/10 ,  C07D401/14 ,  A61K31/4353 ,  A61K31/437 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds of formula (I): wherein R1, R2, R3, R5, R6, A1, A2, A3, A4 assume meanings as defined in formula (I) are inhibitors of neutrophil elastase.

Abstract translation: 式（I）化合物：其中R 1，R 2，R 3，R 5，R 6，A 1，A 2，A 3，A 4定义为式（I）中定义的含义是嗜中性粒细胞弹性蛋白酶抑制剂。