公开(公告)号：US20140343055A1

公开(公告)日：2014-11-20

申请号：US14451600

申请日：2014-08-05

Applicant: Chiesi Farmaceutici S.p.A

Inventor： Monique Bodil Van Niel ,  Nicholas Charles Ray ,  Andrew Peter Cridland ,  Christopher Hurley ,  Lilian Alcaraz ,  Terry Aaron Panchal ,  Andrew Stephen Robert Jennings ,  Elisabetta Armani

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds of formula (I): wherein R2, W, A, Y, and R1 are as defined in the specification, and pharmaceutically acceptable salts thereof, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract translation: 式（I）化合物：其中R2，W，A，Y和R1如说明书中所定义，及其药学上可接受的盐是p38 MAPK抑制剂，可用作抗炎剂，用于治疗 尤其是呼吸道疾病。

公开(公告)号：US08835431B2

公开(公告)日：2014-09-16

申请号：US13708191

申请日：2012-12-07

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Monique Bodil Van Niel ,  Nicholas Charles Ray ,  Andrew Peter Cridland ,  Christopher Hurley ,  Lilian Alcaraz ,  Terry Aaron Panchal ,  Andrew Stephen Robert Jennings ,  Elisabetta Armani

IPC: A61K31/5377 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds of formula (I): wherein R2, W, A, Y, and R1 are as defined in the specification, and pharmaceutically acceptable salts thereof, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract translation: 式（I）化合物：其中R2，W，A，Y和R1如说明书中所定义，及其药学上可接受的盐是p38 MAPK抑制剂，可用作抗炎剂，用于治疗 尤其是呼吸道疾病。

公开(公告)号：US20130150361A1

公开(公告)日：2013-06-13

申请号：US13708191

申请日：2012-12-07

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Monique Bodil Van Niel ,  Nicholas Charles Ray ,  Andrew Peter Cridland ,  Christopher Hurley ,  Lilian Alcaraz ,  Terry Aaron Panchal ,  Andrew Stephen Robert Jennings ,  Elisabetta Armani

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds of formula (I): wherein R2, W, A, Y, and R1 are as defined in the specification, and pharmaceutically acceptable salts thereof, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract translation: 式（I）化合物：其中R2，W，A，Y和R1如说明书中所定义，及其药学上可接受的盐是p38 MAPK抑制剂，可用作抗炎剂，用于治疗 尤其是呼吸道疾病。

公开(公告)号：US20150344475A1

公开(公告)日：2015-12-03

申请号：US14819722

申请日：2015-08-06

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Monique Bodil VAN NIEL ,  Nicholas Charles Ray ,  Lilian Alcaraz ,  Terry Aaron Panchal ,  Andrew Stephen Robert Jennings ,  Elisabetta Armani ,  Andrew Peter Cridland ,  Christopher Hurley

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07C53/06 ,  C07D231/40 ,  C07D401/12 ,  C07D403/12 ,  C07D487/08 ,  C07D498/08 ,  C07D519/00

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract translation: 式（I）化合物及其药学上可接受的盐：其中R2，W，A，Y和R1如说明书中所定义，是p38 MAPK抑制剂，并且可用作抗炎剂， 呼吸道疾病

公开(公告)号：US20140323470A1

公开(公告)日：2014-10-30

申请号：US14330145

申请日：2014-07-14

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Monique Bodil VAN NIEL ,  Nicholas Charles Ray ,  Lilian Alcaraz ,  Terry Aaron Panchal ,  Andrew Stephen Robert Jennings ,  Elisabetta Armani ,  Andrew Peter Cridland ,  Christopher Hurley

IPC: C07D498/08 ,  C07D487/08 ,  C07D403/12 ,  C07D471/04 ,  C07D401/12

CPC classification number: C07D471/04 ,  C07C53/06 ,  C07D231/40 ,  C07D401/12 ,  C07D403/12 ,  C07D487/08 ,  C07D498/08 ,  C07D519/00

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract translation: 式（I）化合物及其药学上可接受的盐：其中R2，W，A，Y和R1如说明书中所定义，是p38MAPK抑制剂，并且可用作抗炎剂， 呼吸道疾病

公开(公告)号：US20140018345A1

公开(公告)日：2014-01-16

申请号：US13940555

申请日：2013-07-12

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Carmelida Capaldi ,  Robert Andrew Heald ,  Nicholas Charles Ray ,  Jonathan Mark Sutton

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds of formula (I): wherein R1, R2, R3, R5, R6, A1, A2, A3, A4 assume meanings as defined in formula (I) are inhibitors of neutrophil elastase.

Abstract translation: 式（I）化合物：其中R 1，R 2，R 3，R 5，R 6，A 1，A 2，A 3，A 4定义为式（I）中定义的含义是嗜中性粒细胞弹性蛋白酶抑制剂。

公开(公告)号：US09029373B2

公开(公告)日：2015-05-12

申请号：US14451600

申请日：2014-08-05

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Monique Bodil Van Niel ,  Nicholas Charles Ray ,  Andrew Peter Cridland ,  Christopher Hurley ,  Lilian Alcaraz ,  Terry Aaron Panchal ,  Andrew Stephen Robert Jennings ,  Elisabetta Armani

IPC: A61K31/5377 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds of formula (I): wherein R2, W, A, Y, and R1 are as defined in the specification, and pharmaceutically acceptable salts thereof, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract translation: 式（I）化合物：其中R2，W，A，Y和R1如说明书中所定义，及其药学上可接受的盐是p38 MAPK抑制剂，可用作抗炎剂，用于治疗 尤其是呼吸道疾病。

公开(公告)号：US09527846B2

公开(公告)日：2016-12-27

申请号：US15131401

申请日：2016-04-18

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Monique Bodil Van Niel ,  Nicholas Charles Ray ,  Lilian Alcaraz ,  Terry Aaron Panchal ,  Andrew Stephen Robert Jennings ,  Elisabetta Armani ,  Andrew Peter Cridland ,  Christopher Hurley

IPC: C07D498/02 ,  A61K31/553 ,  C07D471/04 ,  C07D401/12 ,  C07D403/12 ,  C07D519/00 ,  C07D487/08 ,  C07D498/08 ,  C07C53/06 ,  C07D231/40

CPC classification number: C07D471/04 ,  C07C53/06 ,  C07D231/40 ,  C07D401/12 ,  C07D403/12 ,  C07D487/08 ,  C07D498/08 ,  C07D519/00

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

公开(公告)号：US09315503B2

公开(公告)日：2016-04-19

申请号：US14819722

申请日：2015-08-06

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Monique Bodil Van Niel ,  Nicholas Charles Ray ,  Lilian Alcaraz ,  Terry Aaron Panchal ,  Andrew Stephen Robert Jennings ,  Elisabetta Armani ,  Andrew Peter Cridland ,  Christopher Hurley

IPC: C07D498/02 ,  A61K31/553 ,  C07D471/04

CPC classification number: C07D471/04 ,  C07C53/06 ,  C07D231/40 ,  C07D401/12 ,  C07D403/12 ,  C07D487/08 ,  C07D498/08 ,  C07D519/00

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

公开(公告)号：US09199984B2

公开(公告)日：2015-12-01

申请号：US13940555

申请日：2013-07-12

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Carmelida Capaldi ,  Robert Andrew Heald ,  Nicholas Charles Ray ,  Jonathan Mark Sutton

IPC: C07D401/02 ,  C07D401/10 ,  C07D401/14 ,  A61K31/4353 ,  A61K31/437 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: Compounds of formula (I): wherein R1, R2, R3, R5, R6, A1, A2, A3, A4 assume meanings as defined in formula (I) are inhibitors of neutrophil elastase.

Abstract translation: 式（I）化合物：其中R 1，R 2，R 3，R 5，R 6，A 1，A 2，A 3，A 4定义为式（I）中定义的含义是嗜中性粒细胞弹性蛋白酶抑制剂。