公开(公告)号：US20170073715A1

公开(公告)日：2017-03-16

申请号：US15276661

申请日：2016-09-26

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Jin Sook CHANG ,  Jae Hyun JO ,  Hyun Ae BAE ,  Byeong Cheol SONG ,  Sol KIM ,  Hye Won KIM

IPC: C12P13/12 ,  C12N15/77 ,  C12N15/70 ,  C12N9/16 ,  C12N9/10

CPC classification number: C12P13/12 ,  C12N9/1085 ,  C12N9/16 ,  C12N15/70 ,  C12N15/77 ,  C12P13/06 ,  C12Y205/01065 ,  C12Y301/03003

Abstract: The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having the properties noted above are also provided herein.

Abstract translation: 本发明提供了通过培养具有降低的内源磷酸丝氨酸磷酸酶活性的微生物来制备半胱氨酸或其衍生物的方法。 由这样的生物体产生的O-磷酸丝氨酸然后可以在硫酸酯或表达巯基化酶的微生物的存在下与硫化物反应，以产生半胱氨酸或其衍生物。 具有上述性质的微生物也在本文中提供。