公开(公告)号：US06593471B2

公开(公告)日：2003-07-15

申请号：US10008927

申请日：2001-12-06

申请人： Jinhua J. Song ,  Nathan K. Yee ,  Suresh R. Kapadia

发明人： Jinhua J. Song ,  Nathan K. Yee ,  Suresh R. Kapadia

IPC分类号： C07D41306

CPC分类号： C07D213/61 ,  C07D213/38

摘要： Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.

公开(公告)号：US08946203B2

公开(公告)日：2015-02-03

申请号：US13785034

申请日：2013-03-05

申请人： Asitha Abeywardane ,  Steven Richard Brunette ,  Michael J. Burke ,  Suresh R. Kapadia ,  Thomas Martin Kirrane ,  Matthew Russell Netherton ,  Hossein Razavi ,  Sonia Rodriguez ,  Anjan Saha ,  Robert Sibley ,  Lana Louise Smith-Keenan ,  Hidenori Takahashi ,  Michael Robert Turner ,  Jiang-Ping Wu ,  Erick Richard Roush Young ,  Qiang Zhang ,  Qing Zhang ,  Renee M. Zindell

发明人： Asitha Abeywardane ,  Steven Richard Brunette ,  Michael J. Burke ,  Suresh R. Kapadia ,  Thomas Martin Kirrane ,  Matthew Russell Netherton ,  Hossein Razavi ,  Sonia Rodriguez ,  Anjan Saha ,  Robert Sibley ,  Lana Louise Smith-Keenan ,  Hidenori Takahashi ,  Michael Robert Turner ,  Jiang-Ping Wu ,  Erick Richard Roush Young ,  Qiang Zhang ,  Qing Zhang ,  Renee M. Zindell

IPC分类号： C07D519/00 ,  C07D491/04 ,  C07D487/08 ,  A61K31/357 ,  C07D491/052 ,  C07D405/10 ,  C07D295/096 ,  C07D295/155 ,  C07D513/04 ,  C07D405/14 ,  C07D319/20 ,  C07D405/12 ,  C07D487/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/14 ,  C07D471/10 ,  C07D487/04

CPC分类号： C07D491/052 ,  A61K31/357 ,  C07D295/096 ,  C07D295/155 ,  C07D319/20 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D413/10 ,  C07D417/10 ,  C07D417/14 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D491/04 ,  C07D513/04 ,  C07D519/00

摘要： The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

公开(公告)号：US06613909B2

公开(公告)日：2003-09-02

申请号：US10010459

申请日：2001-12-06

申请人： Jinhua J. Song ,  Nathan K. Yee ,  Suresh R. Kapadia

发明人： Jinhua J. Song ,  Nathan K. Yee ,  Suresh R. Kapadia

IPC分类号： C07D21361

CPC分类号： C07D213/61 ,  C07D213/38

摘要： Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.

摘要翻译： 公开了新的2-（5-卤代吡啶基）和2-（5-卤代嘧啶基）卤化镁，其制备方法及其在各自的5-卤代-2-取代的吡啶和嘧啶中的有效合成中的应用。

公开(公告)号：US06590099B2

公开(公告)日：2003-07-08

申请号：US10010460

申请日：2001-12-06

申请人： Jinhua J. Song ,  Nathan K. Yee ,  Suresh R. Kapadia

发明人： Jinhua J. Song ,  Nathan K. Yee ,  Suresh R. Kapadia

IPC分类号： C07D41306

CPC分类号： C07D213/61 ,  C07D213/38

摘要： Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.