公开(公告)号：US20240417775A1

公开(公告)日：2024-12-19

申请号：US17927525

申请日：2021-05-26

Applicant: Case Western Reserve University

Inventor： Sanford D. Markowitz ,  Helen Moinova ,  Joseph Ready

IPC: C12Q1/6806 ,  A01N1/00 ,  C12N15/10

Abstract: The disclosure provides methods for storage solutions for preserving DNA methylation patterns over a period of time. The disclosure also provides for methods of using methylated DNA stored in such storage solutions.

公开(公告)号：US20220154294A1

公开(公告)日：2022-05-19

申请号：US17590986

申请日：2022-02-02

Applicant: Case Western Reserve University

Inventor： Sanford D. Markowitz ,  Helen Moinova ,  Amitabh Chak ,  Joseph Willis ,  Thomas LaFramboise

IPC: C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/6853 ,  G01N33/574

Abstract: The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.

公开(公告)号：US20190309372A1

公开(公告)日：2019-10-10

申请号：US16315405

申请日：2017-07-05

Applicant: Case Western Reserve University

Inventor： Sanford D. Markowitz ,  Helen Moinova ,  Amitabh Chak ,  Joseph Willis ,  Thomas LaFramboise

IPC: C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/6853

Abstract: The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.